Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients
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Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients. / Al Ghazal, Philipp; Herberger, Katharina; Schaller, Jörg; Strölin, Anke; Hoff, Norman-Philipp; Goerge, Tobias; Roth, Hannelore; Rabe, Eberhard; Karrer, Sigrid; Renner, Regina; Maschke, Jan; Horn, Thomas; Hepp, Julia; Eming, Sabine; Wollina, Uwe; Zutt, Markus; Sick, Isabell; Splieth, Benno; Dill, Dorothea; Klode, Joachim; Dissemond, Joachim.
in: ORPHANET J RARE DIS, Jahrgang 8, 01.01.2013, S. 136.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients
AU - Al Ghazal, Philipp
AU - Herberger, Katharina
AU - Schaller, Jörg
AU - Strölin, Anke
AU - Hoff, Norman-Philipp
AU - Goerge, Tobias
AU - Roth, Hannelore
AU - Rabe, Eberhard
AU - Karrer, Sigrid
AU - Renner, Regina
AU - Maschke, Jan
AU - Horn, Thomas
AU - Hepp, Julia
AU - Eming, Sabine
AU - Wollina, Uwe
AU - Zutt, Markus
AU - Sick, Isabell
AU - Splieth, Benno
AU - Dill, Dorothea
AU - Klode, Joachim
AU - Dissemond, Joachim
PY - 2013/1/1
Y1 - 2013/1/1
N2 - BACKGROUND: Pyoderma gangrenosum (PG) is a rarely diagnosed ulcerative neutrophilic dermatosis with unknown origin that has been poorly characterized in clinical studies so far. Consequently there have been significant discussions about its associated factors and comorbidities. The aim of our multicenter study was to analyze current data from patients in dermatologic wound care centers in Germany in order to describe associated factors and comorbidities in patients with PG.METHODS: Retrospective clinical investigation of patients with PG from dermatologic wound care centers in Germany.RESULTS: We received data from 259 patients with PG from 20 different dermatologic wound care centers in Germany. Of these 142 (54.8%) patients were female, 117 (45.2%) were male; with an age range of 21 to 95 years, and a mean of 58 years. In our patient population we found 45.6% with anemia, 44.8% with endocrine diseases, 12.4% with internal malignancies, 9.3% with chronic inflammatory bowel diseases and 4.3% with elevated creatinine levels. Moreover 25.5% of all patients had a diabetes mellitus with some aspects of potential association with the metabolic syndrome.CONCLUSIONS: Our study describes one of the world's largest populations with PG. Beside the well-known association with chronic bowel diseases and neoplasms, a potentially relevant new aspect is an association with endocrine diseases, in particular the metabolic syndrome, thyroid dysfunctions and renal disorders. Our findings represent clinically relevant new aspects. This may help to describe the patients' characteristics and help to understand the underlying pathophysiology in these often misdiagnosed patients.
AB - BACKGROUND: Pyoderma gangrenosum (PG) is a rarely diagnosed ulcerative neutrophilic dermatosis with unknown origin that has been poorly characterized in clinical studies so far. Consequently there have been significant discussions about its associated factors and comorbidities. The aim of our multicenter study was to analyze current data from patients in dermatologic wound care centers in Germany in order to describe associated factors and comorbidities in patients with PG.METHODS: Retrospective clinical investigation of patients with PG from dermatologic wound care centers in Germany.RESULTS: We received data from 259 patients with PG from 20 different dermatologic wound care centers in Germany. Of these 142 (54.8%) patients were female, 117 (45.2%) were male; with an age range of 21 to 95 years, and a mean of 58 years. In our patient population we found 45.6% with anemia, 44.8% with endocrine diseases, 12.4% with internal malignancies, 9.3% with chronic inflammatory bowel diseases and 4.3% with elevated creatinine levels. Moreover 25.5% of all patients had a diabetes mellitus with some aspects of potential association with the metabolic syndrome.CONCLUSIONS: Our study describes one of the world's largest populations with PG. Beside the well-known association with chronic bowel diseases and neoplasms, a potentially relevant new aspect is an association with endocrine diseases, in particular the metabolic syndrome, thyroid dysfunctions and renal disorders. Our findings represent clinically relevant new aspects. This may help to describe the patients' characteristics and help to understand the underlying pathophysiology in these often misdiagnosed patients.
U2 - 10.1186/1750-1172-8-136
DO - 10.1186/1750-1172-8-136
M3 - SCORING: Journal article
C2 - 24010984
VL - 8
SP - 136
JO - ORPHANET J RARE DIS
JF - ORPHANET J RARE DIS
SN - 1750-1172
ER -