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Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients

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Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients. / Al Ghazal, Philipp; Herberger, Katharina; Schaller, Jörg; Strölin, Anke; Hoff, Norman-Philipp; Goerge, Tobias; Roth, Hannelore; Rabe, Eberhard; Karrer, Sigrid; Renner, Regina; Maschke, Jan; Horn, Thomas; Hepp, Julia; Eming, Sabine; Wollina, Uwe; Zutt, Markus; Sick, Isabell; Splieth, Benno; Dill, Dorothea; Klode, Joachim; Dissemond, Joachim.

In: ORPHANET J RARE DIS, Vol. 8, 01.01.2013, p. 136.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Al Ghazal, P, Herberger, K, Schaller, J, Strölin, A, Hoff, N-P, Goerge, T, Roth, H, Rabe, E, Karrer, S, Renner, R, Maschke, J, Horn, T, Hepp, J, Eming, S, Wollina, U, Zutt, M, Sick, I, Splieth, B, Dill, D, Klode, J & Dissemond, J 2013, 'Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients', ORPHANET J RARE DIS, vol. 8, pp. 136. https://doi.org/10.1186/1750-1172-8-136

APA

Al Ghazal, P., Herberger, K., Schaller, J., Strölin, A., Hoff, N-P., Goerge, T., Roth, H., Rabe, E., Karrer, S., Renner, R., Maschke, J., Horn, T., Hepp, J., Eming, S., Wollina, U., Zutt, M., Sick, I., Splieth, B., Dill, D., ... Dissemond, J. (2013). Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients. ORPHANET J RARE DIS, 8, 136. https://doi.org/10.1186/1750-1172-8-136

Vancouver

Al Ghazal P, Herberger K, Schaller J, Strölin A, Hoff N-P, Goerge T et al. Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients. ORPHANET J RARE DIS. 2013 Jan 1;8:136. https://doi.org/10.1186/1750-1172-8-136

Bibtex

@article{56daa6b7de7b49b3bb61df7156d2504e,
title = "Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients",
abstract = "BACKGROUND: Pyoderma gangrenosum (PG) is a rarely diagnosed ulcerative neutrophilic dermatosis with unknown origin that has been poorly characterized in clinical studies so far. Consequently there have been significant discussions about its associated factors and comorbidities. The aim of our multicenter study was to analyze current data from patients in dermatologic wound care centers in Germany in order to describe associated factors and comorbidities in patients with PG.METHODS: Retrospective clinical investigation of patients with PG from dermatologic wound care centers in Germany.RESULTS: We received data from 259 patients with PG from 20 different dermatologic wound care centers in Germany. Of these 142 (54.8%) patients were female, 117 (45.2%) were male; with an age range of 21 to 95 years, and a mean of 58 years. In our patient population we found 45.6% with anemia, 44.8% with endocrine diseases, 12.4% with internal malignancies, 9.3% with chronic inflammatory bowel diseases and 4.3% with elevated creatinine levels. Moreover 25.5% of all patients had a diabetes mellitus with some aspects of potential association with the metabolic syndrome.CONCLUSIONS: Our study describes one of the world's largest populations with PG. Beside the well-known association with chronic bowel diseases and neoplasms, a potentially relevant new aspect is an association with endocrine diseases, in particular the metabolic syndrome, thyroid dysfunctions and renal disorders. Our findings represent clinically relevant new aspects. This may help to describe the patients' characteristics and help to understand the underlying pathophysiology in these often misdiagnosed patients.",
author = "{Al Ghazal}, Philipp and Katharina Herberger and J{\"o}rg Schaller and Anke Str{\"o}lin and Norman-Philipp Hoff and Tobias Goerge and Hannelore Roth and Eberhard Rabe and Sigrid Karrer and Regina Renner and Jan Maschke and Thomas Horn and Julia Hepp and Sabine Eming and Uwe Wollina and Markus Zutt and Isabell Sick and Benno Splieth and Dorothea Dill and Joachim Klode and Joachim Dissemond",
year = "2013",
month = jan,
day = "1",
doi = "10.1186/1750-1172-8-136",
language = "English",
volume = "8",
pages = "136",
journal = "ORPHANET J RARE DIS",
issn = "1750-1172",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Associated factors and comorbidities in patients with pyoderma gangrenosum in Germany: a retrospective multicentric analysis in 259 patients

AU - Al Ghazal, Philipp

AU - Herberger, Katharina

AU - Schaller, Jörg

AU - Strölin, Anke

AU - Hoff, Norman-Philipp

AU - Goerge, Tobias

AU - Roth, Hannelore

AU - Rabe, Eberhard

AU - Karrer, Sigrid

AU - Renner, Regina

AU - Maschke, Jan

AU - Horn, Thomas

AU - Hepp, Julia

AU - Eming, Sabine

AU - Wollina, Uwe

AU - Zutt, Markus

AU - Sick, Isabell

AU - Splieth, Benno

AU - Dill, Dorothea

AU - Klode, Joachim

AU - Dissemond, Joachim

PY - 2013/1/1

Y1 - 2013/1/1

N2 - BACKGROUND: Pyoderma gangrenosum (PG) is a rarely diagnosed ulcerative neutrophilic dermatosis with unknown origin that has been poorly characterized in clinical studies so far. Consequently there have been significant discussions about its associated factors and comorbidities. The aim of our multicenter study was to analyze current data from patients in dermatologic wound care centers in Germany in order to describe associated factors and comorbidities in patients with PG.METHODS: Retrospective clinical investigation of patients with PG from dermatologic wound care centers in Germany.RESULTS: We received data from 259 patients with PG from 20 different dermatologic wound care centers in Germany. Of these 142 (54.8%) patients were female, 117 (45.2%) were male; with an age range of 21 to 95 years, and a mean of 58 years. In our patient population we found 45.6% with anemia, 44.8% with endocrine diseases, 12.4% with internal malignancies, 9.3% with chronic inflammatory bowel diseases and 4.3% with elevated creatinine levels. Moreover 25.5% of all patients had a diabetes mellitus with some aspects of potential association with the metabolic syndrome.CONCLUSIONS: Our study describes one of the world's largest populations with PG. Beside the well-known association with chronic bowel diseases and neoplasms, a potentially relevant new aspect is an association with endocrine diseases, in particular the metabolic syndrome, thyroid dysfunctions and renal disorders. Our findings represent clinically relevant new aspects. This may help to describe the patients' characteristics and help to understand the underlying pathophysiology in these often misdiagnosed patients.

AB - BACKGROUND: Pyoderma gangrenosum (PG) is a rarely diagnosed ulcerative neutrophilic dermatosis with unknown origin that has been poorly characterized in clinical studies so far. Consequently there have been significant discussions about its associated factors and comorbidities. The aim of our multicenter study was to analyze current data from patients in dermatologic wound care centers in Germany in order to describe associated factors and comorbidities in patients with PG.METHODS: Retrospective clinical investigation of patients with PG from dermatologic wound care centers in Germany.RESULTS: We received data from 259 patients with PG from 20 different dermatologic wound care centers in Germany. Of these 142 (54.8%) patients were female, 117 (45.2%) were male; with an age range of 21 to 95 years, and a mean of 58 years. In our patient population we found 45.6% with anemia, 44.8% with endocrine diseases, 12.4% with internal malignancies, 9.3% with chronic inflammatory bowel diseases and 4.3% with elevated creatinine levels. Moreover 25.5% of all patients had a diabetes mellitus with some aspects of potential association with the metabolic syndrome.CONCLUSIONS: Our study describes one of the world's largest populations with PG. Beside the well-known association with chronic bowel diseases and neoplasms, a potentially relevant new aspect is an association with endocrine diseases, in particular the metabolic syndrome, thyroid dysfunctions and renal disorders. Our findings represent clinically relevant new aspects. This may help to describe the patients' characteristics and help to understand the underlying pathophysiology in these often misdiagnosed patients.

U2 - 10.1186/1750-1172-8-136

DO - 10.1186/1750-1172-8-136

M3 - SCORING: Journal article

C2 - 24010984

VL - 8

SP - 136

JO - ORPHANET J RARE DIS

JF - ORPHANET J RARE DIS

SN - 1750-1172

ER -