Angiotensin-Converting Enzyme 2 Protein Is Overexpressed in a Wide Range of Human Tumour Types: A Systematic Tissue Microarray Study on >15,000 Tumours
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Angiotensin-Converting Enzyme 2 Protein Is Overexpressed in a Wide Range of Human Tumour Types: A Systematic Tissue Microarray Study on >15,000 Tumours. / Meiners, Jan; Jansen, Kristina; Gorbokon, Natalia; Büscheck, Franziska; Luebke, Andreas M; Kluth, Martina; Hube-Magg, Claudia; Höflmayer, Doris; Weidemann, Sören; Fraune, Christoph; Möller, Katharina; Bernreuther, Christian; Lebok, Patrick; Menz, Anne; Jacobsen, Frank; Clauditz, Till; Sauter, Guido; Uhlig, Ria; Wilczak, Waldemar; Izbicki, Jakob; Perez, Daniel; Minner, Sarah; Burandt, Eike; Krech, Till; Marx, Andreas; Simon, Ronald; Steurer, Stefan.
in: BIOMEDICINES, Jahrgang 9, Nr. 12, 1831, 03.12.2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Angiotensin-Converting Enzyme 2 Protein Is Overexpressed in a Wide Range of Human Tumour Types: A Systematic Tissue Microarray Study on >15,000 Tumours
AU - Meiners, Jan
AU - Jansen, Kristina
AU - Gorbokon, Natalia
AU - Büscheck, Franziska
AU - Luebke, Andreas M
AU - Kluth, Martina
AU - Hube-Magg, Claudia
AU - Höflmayer, Doris
AU - Weidemann, Sören
AU - Fraune, Christoph
AU - Möller, Katharina
AU - Bernreuther, Christian
AU - Lebok, Patrick
AU - Menz, Anne
AU - Jacobsen, Frank
AU - Clauditz, Till
AU - Sauter, Guido
AU - Uhlig, Ria
AU - Wilczak, Waldemar
AU - Izbicki, Jakob
AU - Perez, Daniel
AU - Minner, Sarah
AU - Burandt, Eike
AU - Krech, Till
AU - Marx, Andreas
AU - Simon, Ronald
AU - Steurer, Stefan
PY - 2021/12/3
Y1 - 2021/12/3
N2 - Angiotensin-converting enzyme 2 (ACE2) is a regulator in the renin-angiotensin system. ACE2 expression was analysed immunohistochemically in 15,306 samples from 119 tumour types and in 608 samples of 76 normal tissue types. In normal tissue, ACE2 was most abundant in testis and corpus luteum, kidney, small intestine and capillaries of selected organs. At least an occasional weak ACE2 positivity of tumour cells was seen in 83 of 119 (70%) tumour types. ACE2 tumour cell positivity was particularly frequent in papillary (94%) and clear cell (86%) renal cell carcinoma, colorectal adenocarcinoma (81%), mucinous ovarian cancer (61%), cholangiocarcinoma (58%), hepatocellular carcinoma (56%), and in adenocarcinomas of the stomach (47%), pancreas (42%), and the lung (35%). ACE2-positive capillaries were found in 409/12,644 (3%) of analysable tumours, most frequently in tumours with endocrine/neuroendocrine activity. Presence of ACE2-positive capillaries was linked to low stage in papillary thyroid cancer and low grade in neuroendocrine neoplasms. In conclusion, ACE2 expression can occur both in tumour cells and tumour-associated capillaries in a broad variety of different tumour types at highly variable frequencies.
AB - Angiotensin-converting enzyme 2 (ACE2) is a regulator in the renin-angiotensin system. ACE2 expression was analysed immunohistochemically in 15,306 samples from 119 tumour types and in 608 samples of 76 normal tissue types. In normal tissue, ACE2 was most abundant in testis and corpus luteum, kidney, small intestine and capillaries of selected organs. At least an occasional weak ACE2 positivity of tumour cells was seen in 83 of 119 (70%) tumour types. ACE2 tumour cell positivity was particularly frequent in papillary (94%) and clear cell (86%) renal cell carcinoma, colorectal adenocarcinoma (81%), mucinous ovarian cancer (61%), cholangiocarcinoma (58%), hepatocellular carcinoma (56%), and in adenocarcinomas of the stomach (47%), pancreas (42%), and the lung (35%). ACE2-positive capillaries were found in 409/12,644 (3%) of analysable tumours, most frequently in tumours with endocrine/neuroendocrine activity. Presence of ACE2-positive capillaries was linked to low stage in papillary thyroid cancer and low grade in neuroendocrine neoplasms. In conclusion, ACE2 expression can occur both in tumour cells and tumour-associated capillaries in a broad variety of different tumour types at highly variable frequencies.
U2 - 10.3390/biomedicines9121831
DO - 10.3390/biomedicines9121831
M3 - SCORING: Journal article
C2 - 34944647
VL - 9
JO - BIOMEDICINES
JF - BIOMEDICINES
SN - 2227-9059
IS - 12
M1 - 1831
ER -