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Angiotensin-Converting Enzyme 2 Protein Is Overexpressed in a Wide Range of Human Tumour Types: A Systematic Tissue Microarray Study on >15,000 Tumours

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Angiotensin-Converting Enzyme 2 Protein Is Overexpressed in a Wide Range of Human Tumour Types: A Systematic Tissue Microarray Study on >15,000 Tumours. / Meiners, Jan; Jansen, Kristina; Gorbokon, Natalia; Büscheck, Franziska; Luebke, Andreas M; Kluth, Martina; Hube-Magg, Claudia; Höflmayer, Doris; Weidemann, Sören; Fraune, Christoph; Möller, Katharina; Bernreuther, Christian; Lebok, Patrick; Menz, Anne; Jacobsen, Frank; Clauditz, Till; Sauter, Guido; Uhlig, Ria; Wilczak, Waldemar; Izbicki, Jakob; Perez, Daniel; Minner, Sarah; Burandt, Eike; Krech, Till; Marx, Andreas; Simon, Ronald; Steurer, Stefan.

In: BIOMEDICINES, Vol. 9, No. 12, 1831, 03.12.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Meiners, J, Jansen, K, Gorbokon, N, Büscheck, F, Luebke, AM, Kluth, M, Hube-Magg, C, Höflmayer, D, Weidemann, S, Fraune, C, Möller, K, Bernreuther, C, Lebok, P, Menz, A, Jacobsen, F, Clauditz, T, Sauter, G, Uhlig, R, Wilczak, W, Izbicki, J, Perez, D, Minner, S, Burandt, E, Krech, T, Marx, A, Simon, R & Steurer, S 2021, 'Angiotensin-Converting Enzyme 2 Protein Is Overexpressed in a Wide Range of Human Tumour Types: A Systematic Tissue Microarray Study on >15,000 Tumours', BIOMEDICINES, vol. 9, no. 12, 1831. https://doi.org/10.3390/biomedicines9121831

APA

Meiners, J., Jansen, K., Gorbokon, N., Büscheck, F., Luebke, A. M., Kluth, M., Hube-Magg, C., Höflmayer, D., Weidemann, S., Fraune, C., Möller, K., Bernreuther, C., Lebok, P., Menz, A., Jacobsen, F., Clauditz, T., Sauter, G., Uhlig, R., Wilczak, W., ... Steurer, S. (2021). Angiotensin-Converting Enzyme 2 Protein Is Overexpressed in a Wide Range of Human Tumour Types: A Systematic Tissue Microarray Study on >15,000 Tumours. BIOMEDICINES, 9(12), [1831]. https://doi.org/10.3390/biomedicines9121831

Vancouver

Meiners J, Jansen K, Gorbokon N, Büscheck F, Luebke AM, Kluth M et al. Angiotensin-Converting Enzyme 2 Protein Is Overexpressed in a Wide Range of Human Tumour Types: A Systematic Tissue Microarray Study on >15,000 Tumours. BIOMEDICINES. 2021 Dec 3;9(12). 1831. https://doi.org/10.3390/biomedicines9121831

Bibtex

@article{10b6ab498bee44afac07c316cfedea61,
title = "Angiotensin-Converting Enzyme 2 Protein Is Overexpressed in a Wide Range of Human Tumour Types: A Systematic Tissue Microarray Study on >15,000 Tumours",
abstract = "Angiotensin-converting enzyme 2 (ACE2) is a regulator in the renin-angiotensin system. ACE2 expression was analysed immunohistochemically in 15,306 samples from 119 tumour types and in 608 samples of 76 normal tissue types. In normal tissue, ACE2 was most abundant in testis and corpus luteum, kidney, small intestine and capillaries of selected organs. At least an occasional weak ACE2 positivity of tumour cells was seen in 83 of 119 (70%) tumour types. ACE2 tumour cell positivity was particularly frequent in papillary (94%) and clear cell (86%) renal cell carcinoma, colorectal adenocarcinoma (81%), mucinous ovarian cancer (61%), cholangiocarcinoma (58%), hepatocellular carcinoma (56%), and in adenocarcinomas of the stomach (47%), pancreas (42%), and the lung (35%). ACE2-positive capillaries were found in 409/12,644 (3%) of analysable tumours, most frequently in tumours with endocrine/neuroendocrine activity. Presence of ACE2-positive capillaries was linked to low stage in papillary thyroid cancer and low grade in neuroendocrine neoplasms. In conclusion, ACE2 expression can occur both in tumour cells and tumour-associated capillaries in a broad variety of different tumour types at highly variable frequencies.",
author = "Jan Meiners and Kristina Jansen and Natalia Gorbokon and Franziska B{\"u}scheck and Luebke, {Andreas M} and Martina Kluth and Claudia Hube-Magg and Doris H{\"o}flmayer and S{\"o}ren Weidemann and Christoph Fraune and Katharina M{\"o}ller and Christian Bernreuther and Patrick Lebok and Anne Menz and Frank Jacobsen and Till Clauditz and Guido Sauter and Ria Uhlig and Waldemar Wilczak and Jakob Izbicki and Daniel Perez and Sarah Minner and Eike Burandt and Till Krech and Andreas Marx and Ronald Simon and Stefan Steurer",
year = "2021",
month = dec,
day = "3",
doi = "10.3390/biomedicines9121831",
language = "English",
volume = "9",
journal = "BIOMEDICINES",
issn = "2227-9059",
publisher = "MDPI AG",
number = "12",

}

RIS

TY - JOUR

T1 - Angiotensin-Converting Enzyme 2 Protein Is Overexpressed in a Wide Range of Human Tumour Types: A Systematic Tissue Microarray Study on >15,000 Tumours

AU - Meiners, Jan

AU - Jansen, Kristina

AU - Gorbokon, Natalia

AU - Büscheck, Franziska

AU - Luebke, Andreas M

AU - Kluth, Martina

AU - Hube-Magg, Claudia

AU - Höflmayer, Doris

AU - Weidemann, Sören

AU - Fraune, Christoph

AU - Möller, Katharina

AU - Bernreuther, Christian

AU - Lebok, Patrick

AU - Menz, Anne

AU - Jacobsen, Frank

AU - Clauditz, Till

AU - Sauter, Guido

AU - Uhlig, Ria

AU - Wilczak, Waldemar

AU - Izbicki, Jakob

AU - Perez, Daniel

AU - Minner, Sarah

AU - Burandt, Eike

AU - Krech, Till

AU - Marx, Andreas

AU - Simon, Ronald

AU - Steurer, Stefan

PY - 2021/12/3

Y1 - 2021/12/3

N2 - Angiotensin-converting enzyme 2 (ACE2) is a regulator in the renin-angiotensin system. ACE2 expression was analysed immunohistochemically in 15,306 samples from 119 tumour types and in 608 samples of 76 normal tissue types. In normal tissue, ACE2 was most abundant in testis and corpus luteum, kidney, small intestine and capillaries of selected organs. At least an occasional weak ACE2 positivity of tumour cells was seen in 83 of 119 (70%) tumour types. ACE2 tumour cell positivity was particularly frequent in papillary (94%) and clear cell (86%) renal cell carcinoma, colorectal adenocarcinoma (81%), mucinous ovarian cancer (61%), cholangiocarcinoma (58%), hepatocellular carcinoma (56%), and in adenocarcinomas of the stomach (47%), pancreas (42%), and the lung (35%). ACE2-positive capillaries were found in 409/12,644 (3%) of analysable tumours, most frequently in tumours with endocrine/neuroendocrine activity. Presence of ACE2-positive capillaries was linked to low stage in papillary thyroid cancer and low grade in neuroendocrine neoplasms. In conclusion, ACE2 expression can occur both in tumour cells and tumour-associated capillaries in a broad variety of different tumour types at highly variable frequencies.

AB - Angiotensin-converting enzyme 2 (ACE2) is a regulator in the renin-angiotensin system. ACE2 expression was analysed immunohistochemically in 15,306 samples from 119 tumour types and in 608 samples of 76 normal tissue types. In normal tissue, ACE2 was most abundant in testis and corpus luteum, kidney, small intestine and capillaries of selected organs. At least an occasional weak ACE2 positivity of tumour cells was seen in 83 of 119 (70%) tumour types. ACE2 tumour cell positivity was particularly frequent in papillary (94%) and clear cell (86%) renal cell carcinoma, colorectal adenocarcinoma (81%), mucinous ovarian cancer (61%), cholangiocarcinoma (58%), hepatocellular carcinoma (56%), and in adenocarcinomas of the stomach (47%), pancreas (42%), and the lung (35%). ACE2-positive capillaries were found in 409/12,644 (3%) of analysable tumours, most frequently in tumours with endocrine/neuroendocrine activity. Presence of ACE2-positive capillaries was linked to low stage in papillary thyroid cancer and low grade in neuroendocrine neoplasms. In conclusion, ACE2 expression can occur both in tumour cells and tumour-associated capillaries in a broad variety of different tumour types at highly variable frequencies.

U2 - 10.3390/biomedicines9121831

DO - 10.3390/biomedicines9121831

M3 - SCORING: Journal article

C2 - 34944647

VL - 9

JO - BIOMEDICINES

JF - BIOMEDICINES

SN - 2227-9059

IS - 12

M1 - 1831

ER -