Alterations of cerebral glutamate in the euthymic state of patients with bipolar disorder
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Alterations of cerebral glutamate in the euthymic state of patients with bipolar disorder. / Ehrlich, André; Schubert, Florian; Pehrs, Corinna; Gallinat, Jürgen.
in: PSYCHIAT RES, Jahrgang 233, Nr. 2, 30.08.2015, S. 73-80.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Alterations of cerebral glutamate in the euthymic state of patients with bipolar disorder
AU - Ehrlich, André
AU - Schubert, Florian
AU - Pehrs, Corinna
AU - Gallinat, Jürgen
N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
PY - 2015/8/30
Y1 - 2015/8/30
N2 - The pathophysiology of bipolar disorder (BD) mostly remains unclear. However, some findings argue for a dysfunction in glutamatergic neurotransmission in BD. Proton magnetic resonance spectroscopy at 3T was used to determine glutamate concentrations in the anterior cingulate cortex (ACC) and the hippocampus (HC) of euthymic outpatients with BP-I disorder and age- and sex-matched healthy controls. In patients with BD, glutamate concentrations were significantly increased in the ACC and decreased in the HC compared with concentrations in controls. Significant group differences were also measured for N-acetyl aspartate and choline; no differences were found for other metabolites examined. An inverse correlation was observed for glutamate concentrations in the ACC and number of episodes. The findings of the study add to the concept of abnormalities in glutamatergic regulation in the ACC and HC in patients with BD.
AB - The pathophysiology of bipolar disorder (BD) mostly remains unclear. However, some findings argue for a dysfunction in glutamatergic neurotransmission in BD. Proton magnetic resonance spectroscopy at 3T was used to determine glutamate concentrations in the anterior cingulate cortex (ACC) and the hippocampus (HC) of euthymic outpatients with BP-I disorder and age- and sex-matched healthy controls. In patients with BD, glutamate concentrations were significantly increased in the ACC and decreased in the HC compared with concentrations in controls. Significant group differences were also measured for N-acetyl aspartate and choline; no differences were found for other metabolites examined. An inverse correlation was observed for glutamate concentrations in the ACC and number of episodes. The findings of the study add to the concept of abnormalities in glutamatergic regulation in the ACC and HC in patients with BD.
U2 - 10.1016/j.pscychresns.2015.05.010
DO - 10.1016/j.pscychresns.2015.05.010
M3 - SCORING: Journal article
C2 - 26050195
VL - 233
SP - 73
EP - 80
JO - PSYCHIAT RES
JF - PSYCHIAT RES
SN - 0165-1781
IS - 2
ER -