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Alterations of cerebral glutamate in the euthymic state of patients with bipolar disorder

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Alterations of cerebral glutamate in the euthymic state of patients with bipolar disorder. / Ehrlich, André; Schubert, Florian; Pehrs, Corinna; Gallinat, Jürgen.

In: PSYCHIAT RES, Vol. 233, No. 2, 30.08.2015, p. 73-80.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ehrlich, A, Schubert, F, Pehrs, C & Gallinat, J 2015, 'Alterations of cerebral glutamate in the euthymic state of patients with bipolar disorder', PSYCHIAT RES, vol. 233, no. 2, pp. 73-80. https://doi.org/10.1016/j.pscychresns.2015.05.010

APA

Ehrlich, A., Schubert, F., Pehrs, C., & Gallinat, J. (2015). Alterations of cerebral glutamate in the euthymic state of patients with bipolar disorder. PSYCHIAT RES, 233(2), 73-80. https://doi.org/10.1016/j.pscychresns.2015.05.010

Vancouver

Ehrlich A, Schubert F, Pehrs C, Gallinat J. Alterations of cerebral glutamate in the euthymic state of patients with bipolar disorder. PSYCHIAT RES. 2015 Aug 30;233(2):73-80. https://doi.org/10.1016/j.pscychresns.2015.05.010

Bibtex

@article{f3af777e9af94b66915893502a86ce9a,
title = "Alterations of cerebral glutamate in the euthymic state of patients with bipolar disorder",
abstract = "The pathophysiology of bipolar disorder (BD) mostly remains unclear. However, some findings argue for a dysfunction in glutamatergic neurotransmission in BD. Proton magnetic resonance spectroscopy at 3T was used to determine glutamate concentrations in the anterior cingulate cortex (ACC) and the hippocampus (HC) of euthymic outpatients with BP-I disorder and age- and sex-matched healthy controls. In patients with BD, glutamate concentrations were significantly increased in the ACC and decreased in the HC compared with concentrations in controls. Significant group differences were also measured for N-acetyl aspartate and choline; no differences were found for other metabolites examined. An inverse correlation was observed for glutamate concentrations in the ACC and number of episodes. The findings of the study add to the concept of abnormalities in glutamatergic regulation in the ACC and HC in patients with BD.",
author = "Andr{\'e} Ehrlich and Florian Schubert and Corinna Pehrs and J{\"u}rgen Gallinat",
note = "Copyright {\textcopyright} 2015 Elsevier Ireland Ltd. All rights reserved.",
year = "2015",
month = aug,
day = "30",
doi = "10.1016/j.pscychresns.2015.05.010",
language = "English",
volume = "233",
pages = "73--80",
journal = "PSYCHIAT RES",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Alterations of cerebral glutamate in the euthymic state of patients with bipolar disorder

AU - Ehrlich, André

AU - Schubert, Florian

AU - Pehrs, Corinna

AU - Gallinat, Jürgen

N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PY - 2015/8/30

Y1 - 2015/8/30

N2 - The pathophysiology of bipolar disorder (BD) mostly remains unclear. However, some findings argue for a dysfunction in glutamatergic neurotransmission in BD. Proton magnetic resonance spectroscopy at 3T was used to determine glutamate concentrations in the anterior cingulate cortex (ACC) and the hippocampus (HC) of euthymic outpatients with BP-I disorder and age- and sex-matched healthy controls. In patients with BD, glutamate concentrations were significantly increased in the ACC and decreased in the HC compared with concentrations in controls. Significant group differences were also measured for N-acetyl aspartate and choline; no differences were found for other metabolites examined. An inverse correlation was observed for glutamate concentrations in the ACC and number of episodes. The findings of the study add to the concept of abnormalities in glutamatergic regulation in the ACC and HC in patients with BD.

AB - The pathophysiology of bipolar disorder (BD) mostly remains unclear. However, some findings argue for a dysfunction in glutamatergic neurotransmission in BD. Proton magnetic resonance spectroscopy at 3T was used to determine glutamate concentrations in the anterior cingulate cortex (ACC) and the hippocampus (HC) of euthymic outpatients with BP-I disorder and age- and sex-matched healthy controls. In patients with BD, glutamate concentrations were significantly increased in the ACC and decreased in the HC compared with concentrations in controls. Significant group differences were also measured for N-acetyl aspartate and choline; no differences were found for other metabolites examined. An inverse correlation was observed for glutamate concentrations in the ACC and number of episodes. The findings of the study add to the concept of abnormalities in glutamatergic regulation in the ACC and HC in patients with BD.

U2 - 10.1016/j.pscychresns.2015.05.010

DO - 10.1016/j.pscychresns.2015.05.010

M3 - SCORING: Journal article

C2 - 26050195

VL - 233

SP - 73

EP - 80

JO - PSYCHIAT RES

JF - PSYCHIAT RES

SN - 0165-1781

IS - 2

ER -