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X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study

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X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study. / Ungerer, Arthur; Staufer, Theresa; Schmutzler, Oliver; Körnig, Christian; Rothkamm, Kai; Grüner, Florian.

In: CANCERS, Vol. 13, No. 22, 5759, 17.11.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ungerer, A, Staufer, T, Schmutzler, O, Körnig, C, Rothkamm, K & Grüner, F 2021, 'X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study', CANCERS, vol. 13, no. 22, 5759. https://doi.org/10.3390/cancers13225759

APA

Ungerer, A., Staufer, T., Schmutzler, O., Körnig, C., Rothkamm, K., & Grüner, F. (2021). X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study. CANCERS, 13(22), [5759]. https://doi.org/10.3390/cancers13225759

Vancouver

Ungerer A, Staufer T, Schmutzler O, Körnig C, Rothkamm K, Grüner F. X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study. CANCERS. 2021 Nov 17;13(22). 5759. https://doi.org/10.3390/cancers13225759

Bibtex

@article{6a7ef8bfa5394eb1beb1e63a8309451a,
title = "X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study",
abstract = "The growing field of cellular therapies in regenerative medicine and oncology calls for more refined diagnostic tools that are able to investigate and monitor the function and success of said therapies. X-ray Fluorescence Imaging (XFI) can be applied for molecular imaging with nanoparticles, such as gold nanoparticles (GNPs), which can be used in immune cell tracking. We present a Monte Carlo simulation study on the sensitivity of detection and associated radiation dose estimations in an idealized setup of XFI in human-sized objects. Our findings demonstrate the practicability of XFI in human-sized objects, as immune cell tracking with a minimum detection limit of 4.4 × 105 cells or 0.86 μg gold in a cubic volume of 1.78 mm3 can be achieved. Therefore, our results show that the current technological developments form a good basis for high sensitivity XFI.",
author = "Arthur Ungerer and Theresa Staufer and Oliver Schmutzler and Christian K{\"o}rnig and Kai Rothkamm and Florian Gr{\"u}ner",
note = "Bitte den Erstautor Arthur Ungerer der Klinik f{\"u}r Strahlentherapie zuordnen.",
year = "2021",
month = nov,
day = "17",
doi = "10.3390/cancers13225759",
language = "English",
volume = "13",
journal = "CANCERS",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "22",

}

RIS

TY - JOUR

T1 - X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study

AU - Ungerer, Arthur

AU - Staufer, Theresa

AU - Schmutzler, Oliver

AU - Körnig, Christian

AU - Rothkamm, Kai

AU - Grüner, Florian

N1 - Bitte den Erstautor Arthur Ungerer der Klinik für Strahlentherapie zuordnen.

PY - 2021/11/17

Y1 - 2021/11/17

N2 - The growing field of cellular therapies in regenerative medicine and oncology calls for more refined diagnostic tools that are able to investigate and monitor the function and success of said therapies. X-ray Fluorescence Imaging (XFI) can be applied for molecular imaging with nanoparticles, such as gold nanoparticles (GNPs), which can be used in immune cell tracking. We present a Monte Carlo simulation study on the sensitivity of detection and associated radiation dose estimations in an idealized setup of XFI in human-sized objects. Our findings demonstrate the practicability of XFI in human-sized objects, as immune cell tracking with a minimum detection limit of 4.4 × 105 cells or 0.86 μg gold in a cubic volume of 1.78 mm3 can be achieved. Therefore, our results show that the current technological developments form a good basis for high sensitivity XFI.

AB - The growing field of cellular therapies in regenerative medicine and oncology calls for more refined diagnostic tools that are able to investigate and monitor the function and success of said therapies. X-ray Fluorescence Imaging (XFI) can be applied for molecular imaging with nanoparticles, such as gold nanoparticles (GNPs), which can be used in immune cell tracking. We present a Monte Carlo simulation study on the sensitivity of detection and associated radiation dose estimations in an idealized setup of XFI in human-sized objects. Our findings demonstrate the practicability of XFI in human-sized objects, as immune cell tracking with a minimum detection limit of 4.4 × 105 cells or 0.86 μg gold in a cubic volume of 1.78 mm3 can be achieved. Therefore, our results show that the current technological developments form a good basis for high sensitivity XFI.

U2 - 10.3390/cancers13225759

DO - 10.3390/cancers13225759

M3 - SCORING: Journal article

C2 - 34830917

VL - 13

JO - CANCERS

JF - CANCERS

SN - 2072-6694

IS - 22

M1 - 5759

ER -