Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood
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Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood. / Gros, Guillaume; Miranda Marcos, Ruben; Latrille, Anthony; Saitovitch, Ana; Gollier-Briant, Fanny; Fossati, Philippe; Schmidt, Liane; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Desrivières, Sylvane; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Brühl, Rüdiger; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Artiges, Eric; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Poustka, Luise; Hohmann, Sarah; Holz, Nathalie; Fröhner, Juliane H; Smolka, Michael N; Vaidya, Nilakshi; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Lemaitre, Hervé; Vulser, Hélène; IMAGEN Consortium.
In: BRAIN STRUCT FUNCT, Vol. 229, No. 1, 01.2024, p. 15-29.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood
AU - Gros, Guillaume
AU - Miranda Marcos, Ruben
AU - Latrille, Anthony
AU - Saitovitch, Ana
AU - Gollier-Briant, Fanny
AU - Fossati, Philippe
AU - Schmidt, Liane
AU - Banaschewski, Tobias
AU - Barker, Gareth J
AU - Bokde, Arun L W
AU - Desrivières, Sylvane
AU - Grigis, Antoine
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Brühl, Rüdiger
AU - Martinot, Jean-Luc
AU - Paillère Martinot, Marie-Laure
AU - Artiges, Eric
AU - Nees, Frauke
AU - Papadopoulos Orfanos, Dimitri
AU - Poustka, Luise
AU - Hohmann, Sarah
AU - Holz, Nathalie
AU - Fröhner, Juliane H
AU - Smolka, Michael N
AU - Vaidya, Nilakshi
AU - Walter, Henrik
AU - Whelan, Robert
AU - Schumann, Gunter
AU - Lemaitre, Hervé
AU - Vulser, Hélène
AU - IMAGEN Consortium
N1 - © 2023. The Author(s).
PY - 2024/1
Y1 - 2024/1
N2 - A growing number of evidence supports a continued distribution of autistic traits in the general population. However, brain maturation trajectories of autistic traits as well as the influence of sex on these trajectories remain largely unknown. We investigated the association of autistic traits in the general population, with longitudinal gray matter (GM) maturation trajectories during the critical period of adolescence. We assessed 709 community-based adolescents (54.7% women) at age 14 and 22. After testing the effect of sex, we used whole-brain voxel-based morphometry to measure longitudinal GM volumes changes associated with autistic traits measured by the Social Responsiveness Scale (SRS) total and sub-scores. In women, we observed that the SRS was associated with slower GM volume decrease globally and in the left parahippocampus and middle temporal gyrus. The social communication sub-score correlated with slower GM volume decrease in the left parahippocampal, superior temporal gyrus, and pallidum; and the social cognition sub-score correlated with slower GM volume decrease in the left middle temporal gyrus, the right ventromedial prefrontal and orbitofrontal cortex. No longitudinal association was found in men. Autistic traits in young women were found to be associated with specific brain trajectories in regions of the social brain and the reward circuit known to be involved in Autism Spectrum Disorder. These findings support both the hypothesis of an earlier GM maturation associated with autistic traits in adolescence and of protective mechanisms in women. They advocate for further studies on brain trajectories associated with autistic traits in women.
AB - A growing number of evidence supports a continued distribution of autistic traits in the general population. However, brain maturation trajectories of autistic traits as well as the influence of sex on these trajectories remain largely unknown. We investigated the association of autistic traits in the general population, with longitudinal gray matter (GM) maturation trajectories during the critical period of adolescence. We assessed 709 community-based adolescents (54.7% women) at age 14 and 22. After testing the effect of sex, we used whole-brain voxel-based morphometry to measure longitudinal GM volumes changes associated with autistic traits measured by the Social Responsiveness Scale (SRS) total and sub-scores. In women, we observed that the SRS was associated with slower GM volume decrease globally and in the left parahippocampus and middle temporal gyrus. The social communication sub-score correlated with slower GM volume decrease in the left parahippocampal, superior temporal gyrus, and pallidum; and the social cognition sub-score correlated with slower GM volume decrease in the left middle temporal gyrus, the right ventromedial prefrontal and orbitofrontal cortex. No longitudinal association was found in men. Autistic traits in young women were found to be associated with specific brain trajectories in regions of the social brain and the reward circuit known to be involved in Autism Spectrum Disorder. These findings support both the hypothesis of an earlier GM maturation associated with autistic traits in adolescence and of protective mechanisms in women. They advocate for further studies on brain trajectories associated with autistic traits in women.
U2 - 10.1007/s00429-023-02710-2
DO - 10.1007/s00429-023-02710-2
M3 - SCORING: Journal article
C2 - 37819410
VL - 229
SP - 15
EP - 29
JO - BRAIN STRUCT FUNCT
JF - BRAIN STRUCT FUNCT
SN - 1863-2653
IS - 1
ER -