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Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood

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Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood. / Gros, Guillaume; Miranda Marcos, Ruben; Latrille, Anthony; Saitovitch, Ana; Gollier-Briant, Fanny; Fossati, Philippe; Schmidt, Liane; Banaschewski, Tobias; Barker, Gareth J; Bokde, Arun L W; Desrivières, Sylvane; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Brühl, Rüdiger; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure; Artiges, Eric; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Poustka, Luise; Hohmann, Sarah; Holz, Nathalie; Fröhner, Juliane H; Smolka, Michael N; Vaidya, Nilakshi; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Lemaitre, Hervé; Vulser, Hélène; IMAGEN Consortium.

in: BRAIN STRUCT FUNCT, Jahrgang 229, Nr. 1, 01.2024, S. 15-29.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gros, G, Miranda Marcos, R, Latrille, A, Saitovitch, A, Gollier-Briant, F, Fossati, P, Schmidt, L, Banaschewski, T, Barker, GJ, Bokde, ALW, Desrivières, S, Grigis, A, Garavan, H, Gowland, P, Heinz, A, Brühl, R, Martinot, J-L, Paillère Martinot, M-L, Artiges, E, Nees, F, Papadopoulos Orfanos, D, Poustka, L, Hohmann, S, Holz, N, Fröhner, JH, Smolka, MN, Vaidya, N, Walter, H, Whelan, R, Schumann, G, Lemaitre, H, Vulser, H & IMAGEN Consortium 2024, 'Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood', BRAIN STRUCT FUNCT, Jg. 229, Nr. 1, S. 15-29. https://doi.org/10.1007/s00429-023-02710-2

APA

Gros, G., Miranda Marcos, R., Latrille, A., Saitovitch, A., Gollier-Briant, F., Fossati, P., Schmidt, L., Banaschewski, T., Barker, G. J., Bokde, A. L. W., Desrivières, S., Grigis, A., Garavan, H., Gowland, P., Heinz, A., Brühl, R., Martinot, J-L., Paillère Martinot, M-L., Artiges, E., ... IMAGEN Consortium (2024). Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood. BRAIN STRUCT FUNCT, 229(1), 15-29. https://doi.org/10.1007/s00429-023-02710-2

Vancouver

Gros G, Miranda Marcos R, Latrille A, Saitovitch A, Gollier-Briant F, Fossati P et al. Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood. BRAIN STRUCT FUNCT. 2024 Jan;229(1):15-29. https://doi.org/10.1007/s00429-023-02710-2

Bibtex

@article{5a49e3792bea4c3292a67925bf54eee9,
title = "Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood",
abstract = "A growing number of evidence supports a continued distribution of autistic traits in the general population. However, brain maturation trajectories of autistic traits as well as the influence of sex on these trajectories remain largely unknown. We investigated the association of autistic traits in the general population, with longitudinal gray matter (GM) maturation trajectories during the critical period of adolescence. We assessed 709 community-based adolescents (54.7% women) at age 14 and 22. After testing the effect of sex, we used whole-brain voxel-based morphometry to measure longitudinal GM volumes changes associated with autistic traits measured by the Social Responsiveness Scale (SRS) total and sub-scores. In women, we observed that the SRS was associated with slower GM volume decrease globally and in the left parahippocampus and middle temporal gyrus. The social communication sub-score correlated with slower GM volume decrease in the left parahippocampal, superior temporal gyrus, and pallidum; and the social cognition sub-score correlated with slower GM volume decrease in the left middle temporal gyrus, the right ventromedial prefrontal and orbitofrontal cortex. No longitudinal association was found in men. Autistic traits in young women were found to be associated with specific brain trajectories in regions of the social brain and the reward circuit known to be involved in Autism Spectrum Disorder. These findings support both the hypothesis of an earlier GM maturation associated with autistic traits in adolescence and of protective mechanisms in women. They advocate for further studies on brain trajectories associated with autistic traits in women.",
author = "Guillaume Gros and {Miranda Marcos}, Ruben and Anthony Latrille and Ana Saitovitch and Fanny Gollier-Briant and Philippe Fossati and Liane Schmidt and Tobias Banaschewski and Barker, {Gareth J} and Bokde, {Arun L W} and Sylvane Desrivi{\`e}res and Antoine Grigis and Hugh Garavan and Penny Gowland and Andreas Heinz and R{\"u}diger Br{\"u}hl and Jean-Luc Martinot and {Paill{\`e}re Martinot}, Marie-Laure and Eric Artiges and Frauke Nees and {Papadopoulos Orfanos}, Dimitri and Luise Poustka and Sarah Hohmann and Nathalie Holz and Fr{\"o}hner, {Juliane H} and Smolka, {Michael N} and Nilakshi Vaidya and Henrik Walter and Robert Whelan and Gunter Schumann and Herv{\'e} Lemaitre and H{\'e}l{\`e}ne Vulser and {IMAGEN Consortium}",
note = "{\textcopyright} 2023. The Author(s).",
year = "2024",
month = jan,
doi = "10.1007/s00429-023-02710-2",
language = "English",
volume = "229",
pages = "15--29",
journal = "BRAIN STRUCT FUNCT",
issn = "1863-2653",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Whole-brain gray matter maturation trajectories associated with autistic traits from adolescence to early adulthood

AU - Gros, Guillaume

AU - Miranda Marcos, Ruben

AU - Latrille, Anthony

AU - Saitovitch, Ana

AU - Gollier-Briant, Fanny

AU - Fossati, Philippe

AU - Schmidt, Liane

AU - Banaschewski, Tobias

AU - Barker, Gareth J

AU - Bokde, Arun L W

AU - Desrivières, Sylvane

AU - Grigis, Antoine

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Brühl, Rüdiger

AU - Martinot, Jean-Luc

AU - Paillère Martinot, Marie-Laure

AU - Artiges, Eric

AU - Nees, Frauke

AU - Papadopoulos Orfanos, Dimitri

AU - Poustka, Luise

AU - Hohmann, Sarah

AU - Holz, Nathalie

AU - Fröhner, Juliane H

AU - Smolka, Michael N

AU - Vaidya, Nilakshi

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Lemaitre, Hervé

AU - Vulser, Hélène

AU - IMAGEN Consortium

N1 - © 2023. The Author(s).

PY - 2024/1

Y1 - 2024/1

N2 - A growing number of evidence supports a continued distribution of autistic traits in the general population. However, brain maturation trajectories of autistic traits as well as the influence of sex on these trajectories remain largely unknown. We investigated the association of autistic traits in the general population, with longitudinal gray matter (GM) maturation trajectories during the critical period of adolescence. We assessed 709 community-based adolescents (54.7% women) at age 14 and 22. After testing the effect of sex, we used whole-brain voxel-based morphometry to measure longitudinal GM volumes changes associated with autistic traits measured by the Social Responsiveness Scale (SRS) total and sub-scores. In women, we observed that the SRS was associated with slower GM volume decrease globally and in the left parahippocampus and middle temporal gyrus. The social communication sub-score correlated with slower GM volume decrease in the left parahippocampal, superior temporal gyrus, and pallidum; and the social cognition sub-score correlated with slower GM volume decrease in the left middle temporal gyrus, the right ventromedial prefrontal and orbitofrontal cortex. No longitudinal association was found in men. Autistic traits in young women were found to be associated with specific brain trajectories in regions of the social brain and the reward circuit known to be involved in Autism Spectrum Disorder. These findings support both the hypothesis of an earlier GM maturation associated with autistic traits in adolescence and of protective mechanisms in women. They advocate for further studies on brain trajectories associated with autistic traits in women.

AB - A growing number of evidence supports a continued distribution of autistic traits in the general population. However, brain maturation trajectories of autistic traits as well as the influence of sex on these trajectories remain largely unknown. We investigated the association of autistic traits in the general population, with longitudinal gray matter (GM) maturation trajectories during the critical period of adolescence. We assessed 709 community-based adolescents (54.7% women) at age 14 and 22. After testing the effect of sex, we used whole-brain voxel-based morphometry to measure longitudinal GM volumes changes associated with autistic traits measured by the Social Responsiveness Scale (SRS) total and sub-scores. In women, we observed that the SRS was associated with slower GM volume decrease globally and in the left parahippocampus and middle temporal gyrus. The social communication sub-score correlated with slower GM volume decrease in the left parahippocampal, superior temporal gyrus, and pallidum; and the social cognition sub-score correlated with slower GM volume decrease in the left middle temporal gyrus, the right ventromedial prefrontal and orbitofrontal cortex. No longitudinal association was found in men. Autistic traits in young women were found to be associated with specific brain trajectories in regions of the social brain and the reward circuit known to be involved in Autism Spectrum Disorder. These findings support both the hypothesis of an earlier GM maturation associated with autistic traits in adolescence and of protective mechanisms in women. They advocate for further studies on brain trajectories associated with autistic traits in women.

U2 - 10.1007/s00429-023-02710-2

DO - 10.1007/s00429-023-02710-2

M3 - SCORING: Journal article

C2 - 37819410

VL - 229

SP - 15

EP - 29

JO - BRAIN STRUCT FUNCT

JF - BRAIN STRUCT FUNCT

SN - 1863-2653

IS - 1

ER -