White matter integrity of motor connections related to training gains in healthy aging
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White matter integrity of motor connections related to training gains in healthy aging. / Schulz, Robert; Zimerman, Máximo; Timmermann, Jan E; Wessel, Maximilian J; Gerloff, Christian; Hummel, Friedhelm C.
In: NEUROBIOL AGING, Vol. 35, No. 6, 2014, p. 1404-1411.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - White matter integrity of motor connections related to training gains in healthy aging
AU - Schulz, Robert
AU - Zimerman, Máximo
AU - Timmermann, Jan E
AU - Wessel, Maximilian J
AU - Gerloff, Christian
AU - Hummel, Friedhelm C
N1 - Copyright © 2014 Elsevier Inc. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Impaired motor skill acquisition is a feature of older age. Acquisition of new motor skills requires the interplay between different cortical motor areas. Using diffusion tensor imaging we reconstructed cortico-cortical connections between the primary motor cortex (M1) and secondary motor areas in 11 older and 11 young participants who took part in a motor skill acquisition paradigm with the nondominant left hand. Examining the extent to which tract-related integrity correlated with training gains we found that white matter integrity of fibers connecting contralateral M1 with both contralateral (r = 0.85) and ipsilateral supplementary motor areas (r = 0.92) were positively associated in old participants. Also, fibers connecting contralateral M1 with ipsilateral dorsal premotor (r = 0.82) and fibers connecting ipsilateral dorsal premotor and supplementary motor area (r = 0.88) were positively related to skill acquisition (all p < 0.05). A similar structure-behavior relationship was not present in the young control subjects suggesting a critical role of brain structural integrity for motor learning in healthy aging.
AB - Impaired motor skill acquisition is a feature of older age. Acquisition of new motor skills requires the interplay between different cortical motor areas. Using diffusion tensor imaging we reconstructed cortico-cortical connections between the primary motor cortex (M1) and secondary motor areas in 11 older and 11 young participants who took part in a motor skill acquisition paradigm with the nondominant left hand. Examining the extent to which tract-related integrity correlated with training gains we found that white matter integrity of fibers connecting contralateral M1 with both contralateral (r = 0.85) and ipsilateral supplementary motor areas (r = 0.92) were positively associated in old participants. Also, fibers connecting contralateral M1 with ipsilateral dorsal premotor (r = 0.82) and fibers connecting ipsilateral dorsal premotor and supplementary motor area (r = 0.88) were positively related to skill acquisition (all p < 0.05). A similar structure-behavior relationship was not present in the young control subjects suggesting a critical role of brain structural integrity for motor learning in healthy aging.
U2 - 10.1016/j.neurobiolaging.2013.11.024
DO - 10.1016/j.neurobiolaging.2013.11.024
M3 - SCORING: Journal article
C2 - 24387983
VL - 35
SP - 1404
EP - 1411
JO - NEUROBIOL AGING
JF - NEUROBIOL AGING
SN - 0197-4580
IS - 6
ER -