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White matter integrity of motor connections related to training gains in healthy aging

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White matter integrity of motor connections related to training gains in healthy aging. / Schulz, Robert; Zimerman, Máximo; Timmermann, Jan E; Wessel, Maximilian J; Gerloff, Christian; Hummel, Friedhelm C.

in: NEUROBIOL AGING, Jahrgang 35, Nr. 6, 2014, S. 1404-1411.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schulz, R, Zimerman, M, Timmermann, JE, Wessel, MJ, Gerloff, C & Hummel, FC 2014, 'White matter integrity of motor connections related to training gains in healthy aging', NEUROBIOL AGING, Jg. 35, Nr. 6, S. 1404-1411. https://doi.org/10.1016/j.neurobiolaging.2013.11.024

APA

Schulz, R., Zimerman, M., Timmermann, J. E., Wessel, M. J., Gerloff, C., & Hummel, F. C. (2014). White matter integrity of motor connections related to training gains in healthy aging. NEUROBIOL AGING, 35(6), 1404-1411. https://doi.org/10.1016/j.neurobiolaging.2013.11.024

Vancouver

Schulz R, Zimerman M, Timmermann JE, Wessel MJ, Gerloff C, Hummel FC. White matter integrity of motor connections related to training gains in healthy aging. NEUROBIOL AGING. 2014;35(6):1404-1411. https://doi.org/10.1016/j.neurobiolaging.2013.11.024

Bibtex

@article{0d05d7c354984b47a2ef59e98663dad7,
title = "White matter integrity of motor connections related to training gains in healthy aging",
abstract = "Impaired motor skill acquisition is a feature of older age. Acquisition of new motor skills requires the interplay between different cortical motor areas. Using diffusion tensor imaging we reconstructed cortico-cortical connections between the primary motor cortex (M1) and secondary motor areas in 11 older and 11 young participants who took part in a motor skill acquisition paradigm with the nondominant left hand. Examining the extent to which tract-related integrity correlated with training gains we found that white matter integrity of fibers connecting contralateral M1 with both contralateral (r = 0.85) and ipsilateral supplementary motor areas (r = 0.92) were positively associated in old participants. Also, fibers connecting contralateral M1 with ipsilateral dorsal premotor (r = 0.82) and fibers connecting ipsilateral dorsal premotor and supplementary motor area (r = 0.88) were positively related to skill acquisition (all p < 0.05). A similar structure-behavior relationship was not present in the young control subjects suggesting a critical role of brain structural integrity for motor learning in healthy aging.",
author = "Robert Schulz and M{\'a}ximo Zimerman and Timmermann, {Jan E} and Wessel, {Maximilian J} and Christian Gerloff and Hummel, {Friedhelm C}",
note = "Copyright {\textcopyright} 2014 Elsevier Inc. All rights reserved.",
year = "2014",
doi = "10.1016/j.neurobiolaging.2013.11.024",
language = "English",
volume = "35",
pages = "1404--1411",
journal = "NEUROBIOL AGING",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - White matter integrity of motor connections related to training gains in healthy aging

AU - Schulz, Robert

AU - Zimerman, Máximo

AU - Timmermann, Jan E

AU - Wessel, Maximilian J

AU - Gerloff, Christian

AU - Hummel, Friedhelm C

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014

Y1 - 2014

N2 - Impaired motor skill acquisition is a feature of older age. Acquisition of new motor skills requires the interplay between different cortical motor areas. Using diffusion tensor imaging we reconstructed cortico-cortical connections between the primary motor cortex (M1) and secondary motor areas in 11 older and 11 young participants who took part in a motor skill acquisition paradigm with the nondominant left hand. Examining the extent to which tract-related integrity correlated with training gains we found that white matter integrity of fibers connecting contralateral M1 with both contralateral (r = 0.85) and ipsilateral supplementary motor areas (r = 0.92) were positively associated in old participants. Also, fibers connecting contralateral M1 with ipsilateral dorsal premotor (r = 0.82) and fibers connecting ipsilateral dorsal premotor and supplementary motor area (r = 0.88) were positively related to skill acquisition (all p < 0.05). A similar structure-behavior relationship was not present in the young control subjects suggesting a critical role of brain structural integrity for motor learning in healthy aging.

AB - Impaired motor skill acquisition is a feature of older age. Acquisition of new motor skills requires the interplay between different cortical motor areas. Using diffusion tensor imaging we reconstructed cortico-cortical connections between the primary motor cortex (M1) and secondary motor areas in 11 older and 11 young participants who took part in a motor skill acquisition paradigm with the nondominant left hand. Examining the extent to which tract-related integrity correlated with training gains we found that white matter integrity of fibers connecting contralateral M1 with both contralateral (r = 0.85) and ipsilateral supplementary motor areas (r = 0.92) were positively associated in old participants. Also, fibers connecting contralateral M1 with ipsilateral dorsal premotor (r = 0.82) and fibers connecting ipsilateral dorsal premotor and supplementary motor area (r = 0.88) were positively related to skill acquisition (all p < 0.05). A similar structure-behavior relationship was not present in the young control subjects suggesting a critical role of brain structural integrity for motor learning in healthy aging.

U2 - 10.1016/j.neurobiolaging.2013.11.024

DO - 10.1016/j.neurobiolaging.2013.11.024

M3 - SCORING: Journal article

C2 - 24387983

VL - 35

SP - 1404

EP - 1411

JO - NEUROBIOL AGING

JF - NEUROBIOL AGING

SN - 0197-4580

IS - 6

ER -