Research ExplorerPublicationsWarmth Prevents Bone Loss Through the Gut Microbiota

Warmth Prevents Bone Loss Through the Gut Microbiota

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Warmth Prevents Bone Loss Through the Gut Microbiota. / Chevalier, Claire; Kieser, Silas; Çolakoğlu, Melis; Hadadi, Noushin; Brun, Julia; Rigo, Dorothée; Suárez-Zamorano, Nicolas; Spiljar, Martina; Fabbiano, Salvatore; Busse, Björn; Ivanišević, Julijana; Macpherson, Andrew; Bonnet, Nicolas; Trajkovski, Mirko.

In: CELL METAB, Vol. 32, No. 4, 06.10.2020, p. 575-590.e7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Chevalier, C, Kieser, S, Çolakoğlu, M, Hadadi, N, Brun, J, Rigo, D, Suárez-Zamorano, N, Spiljar, M, Fabbiano, S, Busse, B, Ivanišević, J, Macpherson, A, Bonnet, N & Trajkovski, M 2020, 'Warmth Prevents Bone Loss Through the Gut Microbiota', CELL METAB, vol. 32, no. 4, pp. 575-590.e7. https://doi.org/10.1016/j.cmet.2020.08.012

APA

Chevalier, C., Kieser, S., Çolakoğlu, M., Hadadi, N., Brun, J., Rigo, D., Suárez-Zamorano, N., Spiljar, M., Fabbiano, S., Busse, B., Ivanišević, J., Macpherson, A., Bonnet, N., & Trajkovski, M. (2020). Warmth Prevents Bone Loss Through the Gut Microbiota. CELL METAB, 32(4), 575-590.e7. https://doi.org/10.1016/j.cmet.2020.08.012

Vancouver

Chevalier C, Kieser S, Çolakoğlu M, Hadadi N, Brun J, Rigo D et al. Warmth Prevents Bone Loss Through the Gut Microbiota. CELL METAB. 2020 Oct 6;32(4):575-590.e7. https://doi.org/10.1016/j.cmet.2020.08.012

Bibtex

@article{b4b40136438c4904a451693f1a38442d,
title = "Warmth Prevents Bone Loss Through the Gut Microbiota",
abstract = "Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone mass and microarchitectural deterioration. Here, we show that warmth exposure (34°C) protects against ovariectomy-induced bone loss by increasing trabecular bone volume, connectivity density, and thickness, leading to improved biomechanical bone strength in adult female, as well as in young male mice. Transplantation of the warm-adapted microbiota phenocopies the warmth-induced bone effects. Both warmth and warm microbiota transplantation revert the ovariectomy-induced transcriptomics changes of the tibia and increase periosteal bone formation. Combinatorial metagenomics/metabolomics analysis shows that warmth enhances bacterial polyamine biosynthesis, resulting in higher total polyamine levels in vivo. Spermine and spermidine supplementation increases bone strength, while inhibiting polyamine biosynthesis in vivo limits the beneficial warmth effects on the bone. Our data suggest warmth exposure as a potential treatment option for osteoporosis while providing a mechanistic framework for its benefits in bone disease.",
author = "Claire Chevalier and Silas Kieser and Melis {\c C}olakoğlu and Noushin Hadadi and Julia Brun and Doroth{\'e}e Rigo and Nicolas Su{\'a}rez-Zamorano and Martina Spiljar and Salvatore Fabbiano and Bj{\"o}rn Busse and Julijana Ivani{\v s}evi{\'c} and Andrew Macpherson and Nicolas Bonnet and Mirko Trajkovski",
year = "2020",
month = oct,
day = "6",
doi = "10.1016/j.cmet.2020.08.012",
language = "English",
volume = "32",
pages = "575--590.e7",
journal = "CELL METAB",
issn = "1550-4131",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Warmth Prevents Bone Loss Through the Gut Microbiota

AU - Chevalier, Claire

AU - Kieser, Silas

AU - Çolakoğlu, Melis

AU - Hadadi, Noushin

AU - Brun, Julia

AU - Rigo, Dorothée

AU - Suárez-Zamorano, Nicolas

AU - Spiljar, Martina

AU - Fabbiano, Salvatore

AU - Busse, Björn

AU - Ivanišević, Julijana

AU - Macpherson, Andrew

AU - Bonnet, Nicolas

AU - Trajkovski, Mirko

PY - 2020/10/6

Y1 - 2020/10/6

N2 - Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone mass and microarchitectural deterioration. Here, we show that warmth exposure (34°C) protects against ovariectomy-induced bone loss by increasing trabecular bone volume, connectivity density, and thickness, leading to improved biomechanical bone strength in adult female, as well as in young male mice. Transplantation of the warm-adapted microbiota phenocopies the warmth-induced bone effects. Both warmth and warm microbiota transplantation revert the ovariectomy-induced transcriptomics changes of the tibia and increase periosteal bone formation. Combinatorial metagenomics/metabolomics analysis shows that warmth enhances bacterial polyamine biosynthesis, resulting in higher total polyamine levels in vivo. Spermine and spermidine supplementation increases bone strength, while inhibiting polyamine biosynthesis in vivo limits the beneficial warmth effects on the bone. Our data suggest warmth exposure as a potential treatment option for osteoporosis while providing a mechanistic framework for its benefits in bone disease.

AB - Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone mass and microarchitectural deterioration. Here, we show that warmth exposure (34°C) protects against ovariectomy-induced bone loss by increasing trabecular bone volume, connectivity density, and thickness, leading to improved biomechanical bone strength in adult female, as well as in young male mice. Transplantation of the warm-adapted microbiota phenocopies the warmth-induced bone effects. Both warmth and warm microbiota transplantation revert the ovariectomy-induced transcriptomics changes of the tibia and increase periosteal bone formation. Combinatorial metagenomics/metabolomics analysis shows that warmth enhances bacterial polyamine biosynthesis, resulting in higher total polyamine levels in vivo. Spermine and spermidine supplementation increases bone strength, while inhibiting polyamine biosynthesis in vivo limits the beneficial warmth effects on the bone. Our data suggest warmth exposure as a potential treatment option for osteoporosis while providing a mechanistic framework for its benefits in bone disease.

U2 - 10.1016/j.cmet.2020.08.012

DO - 10.1016/j.cmet.2020.08.012

M3 - SCORING: Journal article

C2 - 32916104

VL - 32

SP - 575-590.e7

JO - CELL METAB

JF - CELL METAB

SN - 1550-4131

IS - 4

ER -