Warmth Prevents Bone Loss Through the Gut Microbiota
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Warmth Prevents Bone Loss Through the Gut Microbiota. / Chevalier, Claire; Kieser, Silas; Çolakoğlu, Melis; Hadadi, Noushin; Brun, Julia; Rigo, Dorothée; Suárez-Zamorano, Nicolas; Spiljar, Martina; Fabbiano, Salvatore; Busse, Björn; Ivanišević, Julijana; Macpherson, Andrew; Bonnet, Nicolas; Trajkovski, Mirko.
in: CELL METAB, Jahrgang 32, Nr. 4, 06.10.2020, S. 575-590.e7.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Warmth Prevents Bone Loss Through the Gut Microbiota
AU - Chevalier, Claire
AU - Kieser, Silas
AU - Çolakoğlu, Melis
AU - Hadadi, Noushin
AU - Brun, Julia
AU - Rigo, Dorothée
AU - Suárez-Zamorano, Nicolas
AU - Spiljar, Martina
AU - Fabbiano, Salvatore
AU - Busse, Björn
AU - Ivanišević, Julijana
AU - Macpherson, Andrew
AU - Bonnet, Nicolas
AU - Trajkovski, Mirko
PY - 2020/10/6
Y1 - 2020/10/6
N2 - Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone mass and microarchitectural deterioration. Here, we show that warmth exposure (34°C) protects against ovariectomy-induced bone loss by increasing trabecular bone volume, connectivity density, and thickness, leading to improved biomechanical bone strength in adult female, as well as in young male mice. Transplantation of the warm-adapted microbiota phenocopies the warmth-induced bone effects. Both warmth and warm microbiota transplantation revert the ovariectomy-induced transcriptomics changes of the tibia and increase periosteal bone formation. Combinatorial metagenomics/metabolomics analysis shows that warmth enhances bacterial polyamine biosynthesis, resulting in higher total polyamine levels in vivo. Spermine and spermidine supplementation increases bone strength, while inhibiting polyamine biosynthesis in vivo limits the beneficial warmth effects on the bone. Our data suggest warmth exposure as a potential treatment option for osteoporosis while providing a mechanistic framework for its benefits in bone disease.
AB - Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone mass and microarchitectural deterioration. Here, we show that warmth exposure (34°C) protects against ovariectomy-induced bone loss by increasing trabecular bone volume, connectivity density, and thickness, leading to improved biomechanical bone strength in adult female, as well as in young male mice. Transplantation of the warm-adapted microbiota phenocopies the warmth-induced bone effects. Both warmth and warm microbiota transplantation revert the ovariectomy-induced transcriptomics changes of the tibia and increase periosteal bone formation. Combinatorial metagenomics/metabolomics analysis shows that warmth enhances bacterial polyamine biosynthesis, resulting in higher total polyamine levels in vivo. Spermine and spermidine supplementation increases bone strength, while inhibiting polyamine biosynthesis in vivo limits the beneficial warmth effects on the bone. Our data suggest warmth exposure as a potential treatment option for osteoporosis while providing a mechanistic framework for its benefits in bone disease.
U2 - 10.1016/j.cmet.2020.08.012
DO - 10.1016/j.cmet.2020.08.012
M3 - SCORING: Journal article
C2 - 32916104
VL - 32
SP - 575-590.e7
JO - CELL METAB
JF - CELL METAB
SN - 1550-4131
IS - 4
ER -