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Voltage-Gated Calcium Channels and Their Roles in Cardiac Electrophysiology

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Voltage-Gated Calcium Channels and Their Roles in Cardiac Electrophysiology. / Heijman, Jordi; Molina, Cristina; Voigt, Niels.

Channelopathies in Heart Disease. ed. / Dierk Thomas; Carol Ann Remme. 1. ed. Cham, CH : Springer, Cham, 2019. p. 77-96 (Cardiac and Vascular Biology).

Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

Harvard

Heijman, J, Molina, C & Voigt, N 2019, Voltage-Gated Calcium Channels and Their Roles in Cardiac Electrophysiology. in D Thomas & CA Remme (eds), Channelopathies in Heart Disease. 1 edn, Cardiac and Vascular Biology, Springer, Cham, Cham, CH, pp. 77-96. https://doi.org/10.1007/978-3-319-77812-9_4

APA

Heijman, J., Molina, C., & Voigt, N. (2019). Voltage-Gated Calcium Channels and Their Roles in Cardiac Electrophysiology. In D. Thomas, & C. A. Remme (Eds.), Channelopathies in Heart Disease (1 ed., pp. 77-96). (Cardiac and Vascular Biology). Springer, Cham. https://doi.org/10.1007/978-3-319-77812-9_4

Vancouver

Heijman J, Molina C, Voigt N. Voltage-Gated Calcium Channels and Their Roles in Cardiac Electrophysiology. In Thomas D, Remme CA, editors, Channelopathies in Heart Disease. 1 ed. Cham, CH: Springer, Cham. 2019. p. 77-96. (Cardiac and Vascular Biology). https://doi.org/10.1007/978-3-319-77812-9_4

Bibtex

@inbook{a12c5ca467974a8399fcd0d66aa6249f,
title = "Voltage-Gated Calcium Channels and Their Roles in Cardiac Electrophysiology",
abstract = "In cardiomyocytes voltage-gated Ca2+ channels are major players in cardiac cellular electrophysiology and cellular excitation-contraction coupling. Accordingly, Ca2+ channel dysfunction contributes to the development of cardiac arrhythmias and impaired cardiac contractile function. In addition, Ca2+ entry through voltage-gated Ca2+ channels is an important regulator of gene transcription and cardiac cellular metabolism. In order to fulfil these tasks reliably, Ca2+ channels are highly regulated by specific subunit compositions and various signaling pathways. This chapter provides an overview of the role of voltage-gated Ca2+ channels in cardiac cellular electrophysiology and summarizes their molecular composition, biophysical properties, and regulatory mechanisms, with a special focus on L-type Ca2+ channels.",
author = "Jordi Heijman and Cristina Molina and Niels Voigt",
year = "2019",
month = oct,
day = "26",
doi = "10.1007/978-3-319-77812-9_4",
language = "English",
isbn = "978-3-319-77811-2",
series = "Cardiac and Vascular Biology",
publisher = "Springer, Cham",
pages = "77--96",
editor = "Dierk Thomas and Remme, {Carol Ann}",
booktitle = "Channelopathies in Heart Disease",
edition = "1",

}

RIS

TY - CHAP

T1 - Voltage-Gated Calcium Channels and Their Roles in Cardiac Electrophysiology

AU - Heijman, Jordi

AU - Molina, Cristina

AU - Voigt, Niels

PY - 2019/10/26

Y1 - 2019/10/26

N2 - In cardiomyocytes voltage-gated Ca2+ channels are major players in cardiac cellular electrophysiology and cellular excitation-contraction coupling. Accordingly, Ca2+ channel dysfunction contributes to the development of cardiac arrhythmias and impaired cardiac contractile function. In addition, Ca2+ entry through voltage-gated Ca2+ channels is an important regulator of gene transcription and cardiac cellular metabolism. In order to fulfil these tasks reliably, Ca2+ channels are highly regulated by specific subunit compositions and various signaling pathways. This chapter provides an overview of the role of voltage-gated Ca2+ channels in cardiac cellular electrophysiology and summarizes their molecular composition, biophysical properties, and regulatory mechanisms, with a special focus on L-type Ca2+ channels.

AB - In cardiomyocytes voltage-gated Ca2+ channels are major players in cardiac cellular electrophysiology and cellular excitation-contraction coupling. Accordingly, Ca2+ channel dysfunction contributes to the development of cardiac arrhythmias and impaired cardiac contractile function. In addition, Ca2+ entry through voltage-gated Ca2+ channels is an important regulator of gene transcription and cardiac cellular metabolism. In order to fulfil these tasks reliably, Ca2+ channels are highly regulated by specific subunit compositions and various signaling pathways. This chapter provides an overview of the role of voltage-gated Ca2+ channels in cardiac cellular electrophysiology and summarizes their molecular composition, biophysical properties, and regulatory mechanisms, with a special focus on L-type Ca2+ channels.

U2 - 10.1007/978-3-319-77812-9_4

DO - 10.1007/978-3-319-77812-9_4

M3 - SCORING: Contribution to collected editions/anthologies

SN - 978-3-319-77811-2

T3 - Cardiac and Vascular Biology

SP - 77

EP - 96

BT - Channelopathies in Heart Disease

A2 - Thomas, Dierk

A2 - Remme, Carol Ann

PB - Springer, Cham

CY - Cham, CH

ER -