Voltage-Gated Calcium Channels and Their Roles in Cardiac Electrophysiology
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Voltage-Gated Calcium Channels and Their Roles in Cardiac Electrophysiology. / Heijman, Jordi; Molina, Cristina; Voigt, Niels.
Channelopathies in Heart Disease. Hrsg. / Dierk Thomas; Carol Ann Remme. 1. Aufl. Cham, CH : Springer, Cham, 2019. S. 77-96 (Cardiac and Vascular Biology).Publikationen: SCORING: Beitrag in Buch/Sammelwerk › SCORING: Beitrag in Sammelwerk › Forschung › Begutachtung
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TY - CHAP
T1 - Voltage-Gated Calcium Channels and Their Roles in Cardiac Electrophysiology
AU - Heijman, Jordi
AU - Molina, Cristina
AU - Voigt, Niels
PY - 2019/10/26
Y1 - 2019/10/26
N2 - In cardiomyocytes voltage-gated Ca2+ channels are major players in cardiac cellular electrophysiology and cellular excitation-contraction coupling. Accordingly, Ca2+ channel dysfunction contributes to the development of cardiac arrhythmias and impaired cardiac contractile function. In addition, Ca2+ entry through voltage-gated Ca2+ channels is an important regulator of gene transcription and cardiac cellular metabolism. In order to fulfil these tasks reliably, Ca2+ channels are highly regulated by specific subunit compositions and various signaling pathways. This chapter provides an overview of the role of voltage-gated Ca2+ channels in cardiac cellular electrophysiology and summarizes their molecular composition, biophysical properties, and regulatory mechanisms, with a special focus on L-type Ca2+ channels.
AB - In cardiomyocytes voltage-gated Ca2+ channels are major players in cardiac cellular electrophysiology and cellular excitation-contraction coupling. Accordingly, Ca2+ channel dysfunction contributes to the development of cardiac arrhythmias and impaired cardiac contractile function. In addition, Ca2+ entry through voltage-gated Ca2+ channels is an important regulator of gene transcription and cardiac cellular metabolism. In order to fulfil these tasks reliably, Ca2+ channels are highly regulated by specific subunit compositions and various signaling pathways. This chapter provides an overview of the role of voltage-gated Ca2+ channels in cardiac cellular electrophysiology and summarizes their molecular composition, biophysical properties, and regulatory mechanisms, with a special focus on L-type Ca2+ channels.
U2 - 10.1007/978-3-319-77812-9_4
DO - 10.1007/978-3-319-77812-9_4
M3 - SCORING: Contribution to collected editions/anthologies
SN - 978-3-319-77811-2
T3 - Cardiac and Vascular Biology
SP - 77
EP - 96
BT - Channelopathies in Heart Disease
A2 - Thomas, Dierk
A2 - Remme, Carol Ann
PB - Springer, Cham
CY - Cham, CH
ER -