Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis

Vladimir Dikolayev; Turlybek Tuganbekov; Viacheslav O Nikolaev

doi:10.3389/fphys.2019.01406

Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis

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Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis. / Dikolayev, Vladimir; Tuganbekov, Turlybek; Nikolaev, Viacheslav O.

In: FRONT PHYSIOL, Vol. 10, 2019, p. 1406.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Dikolayev, V, Tuganbekov, T & Nikolaev, VO 2019, 'Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis', FRONT PHYSIOL, vol. 10, pp. 1406. https://doi.org/10.3389/fphys.2019.01406

APA

Dikolayev, V., Tuganbekov, T., & Nikolaev, V. O. (2019). Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis. FRONT PHYSIOL, 10, 1406. https://doi.org/10.3389/fphys.2019.01406

Vancouver

Dikolayev V, Tuganbekov T, Nikolaev VO. Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis. FRONT PHYSIOL. 2019;10:1406. https://doi.org/10.3389/fphys.2019.01406

Bibtex

@article{c1a8670582974076bc206fc5d8172a02,

title = "Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis",

abstract = "3',5'-Cyclic adenosine monophosphate (cAMP) is a key second messenger that regulates function of proteins involved in ion homeostasis and cardiac excitation-contraction coupling. Over the last decade, it has been increasingly appreciated that cAMP conveys its numerous effects by acting in discrete subcellular compartments or {"}microdomains.{"} In this mini review, we describe how such localized signals can be visualized in living cardiomyocytes to better understand cardiac physiology and disease. Special focus is made on targeted biosensors that can be used to resolve second messenger signals within nanometers of cardiac ion channels and transporters. Potential directions for future research and the translational importance of cAMP compartmentalization are discussed.",

author = "Vladimir Dikolayev and Turlybek Tuganbekov and Nikolaev, {Viacheslav O}",

note = "Copyright {\textcopyright} 2019 Dikolayev, Tuganbekov and Nikolaev.",

year = "2019",

doi = "10.3389/fphys.2019.01406",

language = "English",

volume = "10",

pages = "1406",

journal = "FRONT PHYSIOL",

issn = "1664-042X",

publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis

AU - Dikolayev, Vladimir

AU - Tuganbekov, Turlybek

AU - Nikolaev, Viacheslav O

PY - 2019

Y1 - 2019

N2 - 3',5'-Cyclic adenosine monophosphate (cAMP) is a key second messenger that regulates function of proteins involved in ion homeostasis and cardiac excitation-contraction coupling. Over the last decade, it has been increasingly appreciated that cAMP conveys its numerous effects by acting in discrete subcellular compartments or "microdomains." In this mini review, we describe how such localized signals can be visualized in living cardiomyocytes to better understand cardiac physiology and disease. Special focus is made on targeted biosensors that can be used to resolve second messenger signals within nanometers of cardiac ion channels and transporters. Potential directions for future research and the translational importance of cAMP compartmentalization are discussed.

AB - 3',5'-Cyclic adenosine monophosphate (cAMP) is a key second messenger that regulates function of proteins involved in ion homeostasis and cardiac excitation-contraction coupling. Over the last decade, it has been increasingly appreciated that cAMP conveys its numerous effects by acting in discrete subcellular compartments or "microdomains." In this mini review, we describe how such localized signals can be visualized in living cardiomyocytes to better understand cardiac physiology and disease. Special focus is made on targeted biosensors that can be used to resolve second messenger signals within nanometers of cardiac ion channels and transporters. Potential directions for future research and the translational importance of cAMP compartmentalization are discussed.

U2 - 10.3389/fphys.2019.01406

DO - 10.3389/fphys.2019.01406

M3 - SCORING: Review article

C2 - 31849691

VL - 10

SP - 1406

JO - FRONT PHYSIOL

JF - FRONT PHYSIOL

SN - 1664-042X

ER -