Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis
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Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis. / Dikolayev, Vladimir; Tuganbekov, Turlybek; Nikolaev, Viacheslav O.
in: FRONT PHYSIOL, Jahrgang 10, 2019, S. 1406.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Visualizing Cyclic Adenosine Monophosphate in Cardiac Microdomains Involved in Ion Homeostasis
AU - Dikolayev, Vladimir
AU - Tuganbekov, Turlybek
AU - Nikolaev, Viacheslav O
N1 - Copyright © 2019 Dikolayev, Tuganbekov and Nikolaev.
PY - 2019
Y1 - 2019
N2 - 3',5'-Cyclic adenosine monophosphate (cAMP) is a key second messenger that regulates function of proteins involved in ion homeostasis and cardiac excitation-contraction coupling. Over the last decade, it has been increasingly appreciated that cAMP conveys its numerous effects by acting in discrete subcellular compartments or "microdomains." In this mini review, we describe how such localized signals can be visualized in living cardiomyocytes to better understand cardiac physiology and disease. Special focus is made on targeted biosensors that can be used to resolve second messenger signals within nanometers of cardiac ion channels and transporters. Potential directions for future research and the translational importance of cAMP compartmentalization are discussed.
AB - 3',5'-Cyclic adenosine monophosphate (cAMP) is a key second messenger that regulates function of proteins involved in ion homeostasis and cardiac excitation-contraction coupling. Over the last decade, it has been increasingly appreciated that cAMP conveys its numerous effects by acting in discrete subcellular compartments or "microdomains." In this mini review, we describe how such localized signals can be visualized in living cardiomyocytes to better understand cardiac physiology and disease. Special focus is made on targeted biosensors that can be used to resolve second messenger signals within nanometers of cardiac ion channels and transporters. Potential directions for future research and the translational importance of cAMP compartmentalization are discussed.
U2 - 10.3389/fphys.2019.01406
DO - 10.3389/fphys.2019.01406
M3 - SCORING: Review article
C2 - 31849691
VL - 10
SP - 1406
JO - FRONT PHYSIOL
JF - FRONT PHYSIOL
SN - 1664-042X
ER -