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Vasoactive diadenosine polyphosphates in human placenta

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Vasoactive diadenosine polyphosphates in human placenta : possible candidates in the pathophysiology of pre-eclampsia? / Jankowski, J; Yoon, M S; Stephan, N; Zidek, W; Schlüter, H.

In: J HYPERTENS, Vol. 19, No. 3 Pt 2, 03.2001, p. 567-73.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jankowski, J, Yoon, MS, Stephan, N, Zidek, W & Schlüter, H 2001, 'Vasoactive diadenosine polyphosphates in human placenta: possible candidates in the pathophysiology of pre-eclampsia?', J HYPERTENS, vol. 19, no. 3 Pt 2, pp. 567-73.

APA

Jankowski, J., Yoon, M. S., Stephan, N., Zidek, W., & Schlüter, H. (2001). Vasoactive diadenosine polyphosphates in human placenta: possible candidates in the pathophysiology of pre-eclampsia? J HYPERTENS, 19(3 Pt 2), 567-73.

Vancouver

Jankowski J, Yoon MS, Stephan N, Zidek W, Schlüter H. Vasoactive diadenosine polyphosphates in human placenta: possible candidates in the pathophysiology of pre-eclampsia? J HYPERTENS. 2001 Mar;19(3 Pt 2):567-73.

Bibtex

@article{d115116d9fb7434b9ce7f08350340e1d,
title = "Vasoactive diadenosine polyphosphates in human placenta: possible candidates in the pathophysiology of pre-eclampsia?",
abstract = "BACKGROUND: One hypothesis of the pathophysiology of pre-eclampsia is that placentally derived, yet unidentified, vasoactive factors are released into the maternal circulation, causing hypertension.OBJECTIVE: To determine if diadenosine polyphosphates, new potent vasoconstrictors, are present in human placenta.METHODS AND RESULTS: Human placental tissue was homogenated and fractionated by size-exclusion chromatography, affinity chromatography, anion-exchange chromatography and reversed-phase chromatography. In fractions purified to homogeneity, diadenosine diphosphate, diadenosine triphosphate, diadenosine tetraphosphate, diadenosine pentaphosphate, diadenosine hexaphosphate and diadenosine heptaphosphate were identified by matrix-assisted laser desorption/ionization mass spectrometry, retention-time comparison and enzymatic cleavage analysis.CONCLUSIONS: The presence of diadenosine polyphosphates in human placenta makes them possible candidates for involvement in the pathophysiology of pre-eclampsia. However, their contribution to the pathophysiology of eclampsia requires substantiation in further studies.",
keywords = "Blood Vessels, Chromatography, Dinucleoside Phosphates, Female, Humans, Placenta, Pre-Eclampsia, Pregnancy, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Journal Article, Research Support, Non-U.S. Gov't",
author = "J Jankowski and Yoon, {M S} and N Stephan and W Zidek and H Schl{\"u}ter",
year = "2001",
month = mar,
language = "English",
volume = "19",
pages = "567--73",
journal = "J HYPERTENS",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "3 Pt 2",

}

RIS

TY - JOUR

T1 - Vasoactive diadenosine polyphosphates in human placenta

T2 - possible candidates in the pathophysiology of pre-eclampsia?

AU - Jankowski, J

AU - Yoon, M S

AU - Stephan, N

AU - Zidek, W

AU - Schlüter, H

PY - 2001/3

Y1 - 2001/3

N2 - BACKGROUND: One hypothesis of the pathophysiology of pre-eclampsia is that placentally derived, yet unidentified, vasoactive factors are released into the maternal circulation, causing hypertension.OBJECTIVE: To determine if diadenosine polyphosphates, new potent vasoconstrictors, are present in human placenta.METHODS AND RESULTS: Human placental tissue was homogenated and fractionated by size-exclusion chromatography, affinity chromatography, anion-exchange chromatography and reversed-phase chromatography. In fractions purified to homogeneity, diadenosine diphosphate, diadenosine triphosphate, diadenosine tetraphosphate, diadenosine pentaphosphate, diadenosine hexaphosphate and diadenosine heptaphosphate were identified by matrix-assisted laser desorption/ionization mass spectrometry, retention-time comparison and enzymatic cleavage analysis.CONCLUSIONS: The presence of diadenosine polyphosphates in human placenta makes them possible candidates for involvement in the pathophysiology of pre-eclampsia. However, their contribution to the pathophysiology of eclampsia requires substantiation in further studies.

AB - BACKGROUND: One hypothesis of the pathophysiology of pre-eclampsia is that placentally derived, yet unidentified, vasoactive factors are released into the maternal circulation, causing hypertension.OBJECTIVE: To determine if diadenosine polyphosphates, new potent vasoconstrictors, are present in human placenta.METHODS AND RESULTS: Human placental tissue was homogenated and fractionated by size-exclusion chromatography, affinity chromatography, anion-exchange chromatography and reversed-phase chromatography. In fractions purified to homogeneity, diadenosine diphosphate, diadenosine triphosphate, diadenosine tetraphosphate, diadenosine pentaphosphate, diadenosine hexaphosphate and diadenosine heptaphosphate were identified by matrix-assisted laser desorption/ionization mass spectrometry, retention-time comparison and enzymatic cleavage analysis.CONCLUSIONS: The presence of diadenosine polyphosphates in human placenta makes them possible candidates for involvement in the pathophysiology of pre-eclampsia. However, their contribution to the pathophysiology of eclampsia requires substantiation in further studies.

KW - Blood Vessels

KW - Chromatography

KW - Dinucleoside Phosphates

KW - Female

KW - Humans

KW - Placenta

KW - Pre-Eclampsia

KW - Pregnancy

KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - SCORING: Journal article

C2 - 11327631

VL - 19

SP - 567

EP - 573

JO - J HYPERTENS

JF - J HYPERTENS

SN - 0263-6352

IS - 3 Pt 2

ER -