Value of amino-terminal pro B-natriuretic peptide in diagnosing Kawasaki disease
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Value of amino-terminal pro B-natriuretic peptide in diagnosing Kawasaki disease. / McNeal-Davidson, Ariane; Fournier, Anne; Spigelblatt, Linda; Saint-Cyr, Claire; Mir, Thomas S; Nir, Amiram; Dallaire, Frédéric; Cousineau, Jocelyne; Delvin, Edgard; Dahdah, Nagib.
In: PEDIATR INT, Vol. 54, No. 5, 10.2012, p. 627-633.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Value of amino-terminal pro B-natriuretic peptide in diagnosing Kawasaki disease
AU - McNeal-Davidson, Ariane
AU - Fournier, Anne
AU - Spigelblatt, Linda
AU - Saint-Cyr, Claire
AU - Mir, Thomas S
AU - Nir, Amiram
AU - Dallaire, Frédéric
AU - Cousineau, Jocelyne
AU - Delvin, Edgard
AU - Dahdah, Nagib
N1 - © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
PY - 2012/10
Y1 - 2012/10
N2 - BACKGROUND: The aim of the present study was to investigate the diagnostic value of the N-terminal B-type natriuretic peptide (NT-proBNP) in acute Kawasaki disease (KD) given that the clinical criteria and the current basic laboratory tests lack the necessary specificity for accurate diagnosis.METHODS: Basic biological tests and serum NT-proBNP levels obtained from acute KD patients were compared to that of febrile controls. NT-proBNP was considered abnormal based on the following definitions: above a cut-off determined on receiver operator characteristic (ROC) analysis, above the upper limit for age, or above 2 SD calculated from healthy children. Analyses were also performed for KD cases with complete or incomplete criteria combined and separately.RESULTS: There were 81 patients and 49 controls aged 3.60 ± 2.77 versus 4.25 ± 3.88 years (P= 0.69). ROC analysis yielded significant area under the curve for NT-proBNP. The sensitivity, specificity, positive and negative predictive values were 70.4-88.9%, 69.4-91.8%, 82.8-93.4%, and 65.2-79.1%. The odds ratios based on NT-proBNP definitions varied between 18.13 (95% confidence interval [CI]: 7.21-45.57), 20.82 (95%CI: 8.18-53.0), and 26.71 (95%CI: 8.64-82.57; P < 0.001). Results were reproducible for cases with complete or incomplete criteria separately.CONCLUSION: NT-proBNP is a reliable marker for the diagnosis of KD. Prospective clinical studies with emphasis on NT-proBNP in a diagnostic algorithm are needed.
AB - BACKGROUND: The aim of the present study was to investigate the diagnostic value of the N-terminal B-type natriuretic peptide (NT-proBNP) in acute Kawasaki disease (KD) given that the clinical criteria and the current basic laboratory tests lack the necessary specificity for accurate diagnosis.METHODS: Basic biological tests and serum NT-proBNP levels obtained from acute KD patients were compared to that of febrile controls. NT-proBNP was considered abnormal based on the following definitions: above a cut-off determined on receiver operator characteristic (ROC) analysis, above the upper limit for age, or above 2 SD calculated from healthy children. Analyses were also performed for KD cases with complete or incomplete criteria combined and separately.RESULTS: There were 81 patients and 49 controls aged 3.60 ± 2.77 versus 4.25 ± 3.88 years (P= 0.69). ROC analysis yielded significant area under the curve for NT-proBNP. The sensitivity, specificity, positive and negative predictive values were 70.4-88.9%, 69.4-91.8%, 82.8-93.4%, and 65.2-79.1%. The odds ratios based on NT-proBNP definitions varied between 18.13 (95% confidence interval [CI]: 7.21-45.57), 20.82 (95%CI: 8.18-53.0), and 26.71 (95%CI: 8.64-82.57; P < 0.001). Results were reproducible for cases with complete or incomplete criteria separately.CONCLUSION: NT-proBNP is a reliable marker for the diagnosis of KD. Prospective clinical studies with emphasis on NT-proBNP in a diagnostic algorithm are needed.
KW - Biomarkers/blood
KW - Child
KW - Child, Preschool
KW - Female
KW - Humans
KW - Infant
KW - Male
KW - Mucocutaneous Lymph Node Syndrome/blood
KW - Natriuretic Peptide, Brain/blood
KW - Peptide Fragments/blood
KW - Predictive Value of Tests
KW - Prospective Studies
KW - ROC Curve
KW - Sensitivity and Specificity
U2 - 10.1111/j.1442-200X.2012.03609.x
DO - 10.1111/j.1442-200X.2012.03609.x
M3 - SCORING: Journal article
C2 - 22414326
VL - 54
SP - 627
EP - 633
JO - PEDIATR INT
JF - PEDIATR INT
SN - 1328-8067
IS - 5
ER -