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Value of amino-terminal pro B-natriuretic peptide in diagnosing Kawasaki disease

Standard

Value of amino-terminal pro B-natriuretic peptide in diagnosing Kawasaki disease. / McNeal-Davidson, Ariane; Fournier, Anne; Spigelblatt, Linda; Saint-Cyr, Claire; Mir, Thomas S; Nir, Amiram; Dallaire, Frédéric; Cousineau, Jocelyne; Delvin, Edgard; Dahdah, Nagib.

in: PEDIATR INT, Jahrgang 54, Nr. 5, 10.2012, S. 627-633.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

McNeal-Davidson, A, Fournier, A, Spigelblatt, L, Saint-Cyr, C, Mir, TS, Nir, A, Dallaire, F, Cousineau, J, Delvin, E & Dahdah, N 2012, 'Value of amino-terminal pro B-natriuretic peptide in diagnosing Kawasaki disease', PEDIATR INT, Jg. 54, Nr. 5, S. 627-633. https://doi.org/10.1111/j.1442-200X.2012.03609.x

APA

McNeal-Davidson, A., Fournier, A., Spigelblatt, L., Saint-Cyr, C., Mir, T. S., Nir, A., Dallaire, F., Cousineau, J., Delvin, E., & Dahdah, N. (2012). Value of amino-terminal pro B-natriuretic peptide in diagnosing Kawasaki disease. PEDIATR INT, 54(5), 627-633. https://doi.org/10.1111/j.1442-200X.2012.03609.x

Vancouver

McNeal-Davidson A, Fournier A, Spigelblatt L, Saint-Cyr C, Mir TS, Nir A et al. Value of amino-terminal pro B-natriuretic peptide in diagnosing Kawasaki disease. PEDIATR INT. 2012 Okt;54(5):627-633. https://doi.org/10.1111/j.1442-200X.2012.03609.x

Bibtex

@article{7290e56adb9a4dd3855b24637a01617d,
title = "Value of amino-terminal pro B-natriuretic peptide in diagnosing Kawasaki disease",
abstract = "BACKGROUND: The aim of the present study was to investigate the diagnostic value of the N-terminal B-type natriuretic peptide (NT-proBNP) in acute Kawasaki disease (KD) given that the clinical criteria and the current basic laboratory tests lack the necessary specificity for accurate diagnosis.METHODS: Basic biological tests and serum NT-proBNP levels obtained from acute KD patients were compared to that of febrile controls. NT-proBNP was considered abnormal based on the following definitions: above a cut-off determined on receiver operator characteristic (ROC) analysis, above the upper limit for age, or above 2 SD calculated from healthy children. Analyses were also performed for KD cases with complete or incomplete criteria combined and separately.RESULTS: There were 81 patients and 49 controls aged 3.60 ± 2.77 versus 4.25 ± 3.88 years (P= 0.69). ROC analysis yielded significant area under the curve for NT-proBNP. The sensitivity, specificity, positive and negative predictive values were 70.4-88.9%, 69.4-91.8%, 82.8-93.4%, and 65.2-79.1%. The odds ratios based on NT-proBNP definitions varied between 18.13 (95% confidence interval [CI]: 7.21-45.57), 20.82 (95%CI: 8.18-53.0), and 26.71 (95%CI: 8.64-82.57; P < 0.001). Results were reproducible for cases with complete or incomplete criteria separately.CONCLUSION: NT-proBNP is a reliable marker for the diagnosis of KD. Prospective clinical studies with emphasis on NT-proBNP in a diagnostic algorithm are needed.",
keywords = "Biomarkers/blood, Child, Child, Preschool, Female, Humans, Infant, Male, Mucocutaneous Lymph Node Syndrome/blood, Natriuretic Peptide, Brain/blood, Peptide Fragments/blood, Predictive Value of Tests, Prospective Studies, ROC Curve, Sensitivity and Specificity",
author = "Ariane McNeal-Davidson and Anne Fournier and Linda Spigelblatt and Claire Saint-Cyr and Mir, {Thomas S} and Amiram Nir and Fr{\'e}d{\'e}ric Dallaire and Jocelyne Cousineau and Edgard Delvin and Nagib Dahdah",
note = "{\textcopyright} 2012 The Authors. Pediatrics International {\textcopyright} 2012 Japan Pediatric Society.",
year = "2012",
month = oct,
doi = "10.1111/j.1442-200X.2012.03609.x",
language = "English",
volume = "54",
pages = "627--633",
journal = "PEDIATR INT",
issn = "1328-8067",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Value of amino-terminal pro B-natriuretic peptide in diagnosing Kawasaki disease

AU - McNeal-Davidson, Ariane

AU - Fournier, Anne

AU - Spigelblatt, Linda

AU - Saint-Cyr, Claire

AU - Mir, Thomas S

AU - Nir, Amiram

AU - Dallaire, Frédéric

AU - Cousineau, Jocelyne

AU - Delvin, Edgard

AU - Dahdah, Nagib

N1 - © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.

PY - 2012/10

Y1 - 2012/10

N2 - BACKGROUND: The aim of the present study was to investigate the diagnostic value of the N-terminal B-type natriuretic peptide (NT-proBNP) in acute Kawasaki disease (KD) given that the clinical criteria and the current basic laboratory tests lack the necessary specificity for accurate diagnosis.METHODS: Basic biological tests and serum NT-proBNP levels obtained from acute KD patients were compared to that of febrile controls. NT-proBNP was considered abnormal based on the following definitions: above a cut-off determined on receiver operator characteristic (ROC) analysis, above the upper limit for age, or above 2 SD calculated from healthy children. Analyses were also performed for KD cases with complete or incomplete criteria combined and separately.RESULTS: There were 81 patients and 49 controls aged 3.60 ± 2.77 versus 4.25 ± 3.88 years (P= 0.69). ROC analysis yielded significant area under the curve for NT-proBNP. The sensitivity, specificity, positive and negative predictive values were 70.4-88.9%, 69.4-91.8%, 82.8-93.4%, and 65.2-79.1%. The odds ratios based on NT-proBNP definitions varied between 18.13 (95% confidence interval [CI]: 7.21-45.57), 20.82 (95%CI: 8.18-53.0), and 26.71 (95%CI: 8.64-82.57; P < 0.001). Results were reproducible for cases with complete or incomplete criteria separately.CONCLUSION: NT-proBNP is a reliable marker for the diagnosis of KD. Prospective clinical studies with emphasis on NT-proBNP in a diagnostic algorithm are needed.

AB - BACKGROUND: The aim of the present study was to investigate the diagnostic value of the N-terminal B-type natriuretic peptide (NT-proBNP) in acute Kawasaki disease (KD) given that the clinical criteria and the current basic laboratory tests lack the necessary specificity for accurate diagnosis.METHODS: Basic biological tests and serum NT-proBNP levels obtained from acute KD patients were compared to that of febrile controls. NT-proBNP was considered abnormal based on the following definitions: above a cut-off determined on receiver operator characteristic (ROC) analysis, above the upper limit for age, or above 2 SD calculated from healthy children. Analyses were also performed for KD cases with complete or incomplete criteria combined and separately.RESULTS: There were 81 patients and 49 controls aged 3.60 ± 2.77 versus 4.25 ± 3.88 years (P= 0.69). ROC analysis yielded significant area under the curve for NT-proBNP. The sensitivity, specificity, positive and negative predictive values were 70.4-88.9%, 69.4-91.8%, 82.8-93.4%, and 65.2-79.1%. The odds ratios based on NT-proBNP definitions varied between 18.13 (95% confidence interval [CI]: 7.21-45.57), 20.82 (95%CI: 8.18-53.0), and 26.71 (95%CI: 8.64-82.57; P < 0.001). Results were reproducible for cases with complete or incomplete criteria separately.CONCLUSION: NT-proBNP is a reliable marker for the diagnosis of KD. Prospective clinical studies with emphasis on NT-proBNP in a diagnostic algorithm are needed.

KW - Biomarkers/blood

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Infant

KW - Male

KW - Mucocutaneous Lymph Node Syndrome/blood

KW - Natriuretic Peptide, Brain/blood

KW - Peptide Fragments/blood

KW - Predictive Value of Tests

KW - Prospective Studies

KW - ROC Curve

KW - Sensitivity and Specificity

U2 - 10.1111/j.1442-200X.2012.03609.x

DO - 10.1111/j.1442-200X.2012.03609.x

M3 - SCORING: Journal article

C2 - 22414326

VL - 54

SP - 627

EP - 633

JO - PEDIATR INT

JF - PEDIATR INT

SN - 1328-8067

IS - 5

ER -