Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation
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Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation. / Spyridonidis, Alexandros; Labopin, Myriam; Gedde-Dahl, Tobias; Ganser, Arnold; Stelljes, Matthias; Craddock, Charles; Wagner-Drouet, Eva Maria; Versluis, Jurjen; Schroeder, Thomas; Blau, Igor Wolfgang; Wulf, Gerald G; Dreger, Peter; Olesen, Gitte; Sengeloev, Henrik; Kröger, Nicolaus; Potter, Victoria; Forcade, Edouard; Passweg, Jakob; de Latour, Régis Peffault; Maertens, Johan; Wilson, Keith M O; Bourhis, Jean Henri; Finke, Juergen; Brissot, Eolia; Bazarbachi, Ali; Giebel, Sebastian; Savani, Bipin P; Nagler, Arnon; Ciceri, Fabio; Mohty, Mohamad.
In: BONE MARROW TRANSPL, Vol. 59, No. 2, 02.2024, p. 217-223.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation
AU - Spyridonidis, Alexandros
AU - Labopin, Myriam
AU - Gedde-Dahl, Tobias
AU - Ganser, Arnold
AU - Stelljes, Matthias
AU - Craddock, Charles
AU - Wagner-Drouet, Eva Maria
AU - Versluis, Jurjen
AU - Schroeder, Thomas
AU - Blau, Igor Wolfgang
AU - Wulf, Gerald G
AU - Dreger, Peter
AU - Olesen, Gitte
AU - Sengeloev, Henrik
AU - Kröger, Nicolaus
AU - Potter, Victoria
AU - Forcade, Edouard
AU - Passweg, Jakob
AU - de Latour, Régis Peffault
AU - Maertens, Johan
AU - Wilson, Keith M O
AU - Bourhis, Jean Henri
AU - Finke, Juergen
AU - Brissot, Eolia
AU - Bazarbachi, Ali
AU - Giebel, Sebastian
AU - Savani, Bipin P
AU - Nagler, Arnon
AU - Ciceri, Fabio
AU - Mohty, Mohamad
N1 - © 2023. The Author(s).
PY - 2024/2
Y1 - 2024/2
N2 - The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning intensity (TCI) score to stratify the preparative regimens of allo-HCT, we used an independent and contemporary patient cohort of 4060 transplant recipients with acute myeloid leukemia meeting inclusion criteria from the discovery study (allo-HCT in first complete remission, matched donor), but who were allografted in a more recent period (2018-2021) and were one decade older (55-75 years, median 63.4 years), we assigned them to a TCI category (low n = 1934, 48%; intermediate n = 1948, 48%, high n = 178, 4%) according to the calculated TCI score ([1-2], [2.5-3.5], [4-6], respectively), and examined the validity of the TCI category in predicting early non-relapse mortality (NRM), 2-year NRM and relapse (REL). In the unadjusted comparison, the TCI index provided a significant risk stratification for d100 and d180 NRM, NRM and REL risk. In the multivariate analysis adjusted for significant variables, there was an independent association of TCI with early NRM, NRM and REL. In summary, we confirm in contemporary treated patients that TCI reflects the conditioning regimen related morbidity and anti-leukemic efficacy satisfactorily and across other established prognostic factors.
AB - The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning intensity (TCI) score to stratify the preparative regimens of allo-HCT, we used an independent and contemporary patient cohort of 4060 transplant recipients with acute myeloid leukemia meeting inclusion criteria from the discovery study (allo-HCT in first complete remission, matched donor), but who were allografted in a more recent period (2018-2021) and were one decade older (55-75 years, median 63.4 years), we assigned them to a TCI category (low n = 1934, 48%; intermediate n = 1948, 48%, high n = 178, 4%) according to the calculated TCI score ([1-2], [2.5-3.5], [4-6], respectively), and examined the validity of the TCI category in predicting early non-relapse mortality (NRM), 2-year NRM and relapse (REL). In the unadjusted comparison, the TCI index provided a significant risk stratification for d100 and d180 NRM, NRM and REL risk. In the multivariate analysis adjusted for significant variables, there was an independent association of TCI with early NRM, NRM and REL. In summary, we confirm in contemporary treated patients that TCI reflects the conditioning regimen related morbidity and anti-leukemic efficacy satisfactorily and across other established prognostic factors.
U2 - 10.1038/s41409-023-02139-5
DO - 10.1038/s41409-023-02139-5
M3 - SCORING: Journal article
C2 - 37978322
VL - 59
SP - 217
EP - 223
JO - BONE MARROW TRANSPL
JF - BONE MARROW TRANSPL
SN - 0268-3369
IS - 2
ER -