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Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation

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Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation. / Spyridonidis, Alexandros; Labopin, Myriam; Gedde-Dahl, Tobias; Ganser, Arnold; Stelljes, Matthias; Craddock, Charles; Wagner-Drouet, Eva Maria; Versluis, Jurjen; Schroeder, Thomas; Blau, Igor Wolfgang; Wulf, Gerald G; Dreger, Peter; Olesen, Gitte; Sengeloev, Henrik; Kröger, Nicolaus; Potter, Victoria; Forcade, Edouard; Passweg, Jakob; de Latour, Régis Peffault; Maertens, Johan; Wilson, Keith M O; Bourhis, Jean Henri; Finke, Juergen; Brissot, Eolia; Bazarbachi, Ali; Giebel, Sebastian; Savani, Bipin P; Nagler, Arnon; Ciceri, Fabio; Mohty, Mohamad.

in: BONE MARROW TRANSPL, Jahrgang 59, Nr. 2, 02.2024, S. 217-223.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Spyridonidis, A, Labopin, M, Gedde-Dahl, T, Ganser, A, Stelljes, M, Craddock, C, Wagner-Drouet, EM, Versluis, J, Schroeder, T, Blau, IW, Wulf, GG, Dreger, P, Olesen, G, Sengeloev, H, Kröger, N, Potter, V, Forcade, E, Passweg, J, de Latour, RP, Maertens, J, Wilson, KMO, Bourhis, JH, Finke, J, Brissot, E, Bazarbachi, A, Giebel, S, Savani, BP, Nagler, A, Ciceri, F & Mohty, M 2024, 'Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation', BONE MARROW TRANSPL, Jg. 59, Nr. 2, S. 217-223. https://doi.org/10.1038/s41409-023-02139-5

APA

Spyridonidis, A., Labopin, M., Gedde-Dahl, T., Ganser, A., Stelljes, M., Craddock, C., Wagner-Drouet, E. M., Versluis, J., Schroeder, T., Blau, I. W., Wulf, G. G., Dreger, P., Olesen, G., Sengeloev, H., Kröger, N., Potter, V., Forcade, E., Passweg, J., de Latour, R. P., ... Mohty, M. (2024). Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation. BONE MARROW TRANSPL, 59(2), 217-223. https://doi.org/10.1038/s41409-023-02139-5

Vancouver

Spyridonidis A, Labopin M, Gedde-Dahl T, Ganser A, Stelljes M, Craddock C et al. Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation. BONE MARROW TRANSPL. 2024 Feb;59(2):217-223. https://doi.org/10.1038/s41409-023-02139-5

Bibtex

@article{44373e890a114c8b8e484a3920168290,
title = "Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation",
abstract = "The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning intensity (TCI) score to stratify the preparative regimens of allo-HCT, we used an independent and contemporary patient cohort of 4060 transplant recipients with acute myeloid leukemia meeting inclusion criteria from the discovery study (allo-HCT in first complete remission, matched donor), but who were allografted in a more recent period (2018-2021) and were one decade older (55-75 years, median 63.4 years), we assigned them to a TCI category (low n = 1934, 48%; intermediate n = 1948, 48%, high n = 178, 4%) according to the calculated TCI score ([1-2], [2.5-3.5], [4-6], respectively), and examined the validity of the TCI category in predicting early non-relapse mortality (NRM), 2-year NRM and relapse (REL). In the unadjusted comparison, the TCI index provided a significant risk stratification for d100 and d180 NRM, NRM and REL risk. In the multivariate analysis adjusted for significant variables, there was an independent association of TCI with early NRM, NRM and REL. In summary, we confirm in contemporary treated patients that TCI reflects the conditioning regimen related morbidity and anti-leukemic efficacy satisfactorily and across other established prognostic factors.",
author = "Alexandros Spyridonidis and Myriam Labopin and Tobias Gedde-Dahl and Arnold Ganser and Matthias Stelljes and Charles Craddock and Wagner-Drouet, {Eva Maria} and Jurjen Versluis and Thomas Schroeder and Blau, {Igor Wolfgang} and Wulf, {Gerald G} and Peter Dreger and Gitte Olesen and Henrik Sengeloev and Nicolaus Kr{\"o}ger and Victoria Potter and Edouard Forcade and Jakob Passweg and {de Latour}, {R{\'e}gis Peffault} and Johan Maertens and Wilson, {Keith M O} and Bourhis, {Jean Henri} and Juergen Finke and Eolia Brissot and Ali Bazarbachi and Sebastian Giebel and Savani, {Bipin P} and Arnon Nagler and Fabio Ciceri and Mohamad Mohty",
note = "{\textcopyright} 2023. The Author(s).",
year = "2024",
month = feb,
doi = "10.1038/s41409-023-02139-5",
language = "English",
volume = "59",
pages = "217--223",
journal = "BONE MARROW TRANSPL",
issn = "0268-3369",
publisher = "NATURE PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation

AU - Spyridonidis, Alexandros

AU - Labopin, Myriam

AU - Gedde-Dahl, Tobias

AU - Ganser, Arnold

AU - Stelljes, Matthias

AU - Craddock, Charles

AU - Wagner-Drouet, Eva Maria

AU - Versluis, Jurjen

AU - Schroeder, Thomas

AU - Blau, Igor Wolfgang

AU - Wulf, Gerald G

AU - Dreger, Peter

AU - Olesen, Gitte

AU - Sengeloev, Henrik

AU - Kröger, Nicolaus

AU - Potter, Victoria

AU - Forcade, Edouard

AU - Passweg, Jakob

AU - de Latour, Régis Peffault

AU - Maertens, Johan

AU - Wilson, Keith M O

AU - Bourhis, Jean Henri

AU - Finke, Juergen

AU - Brissot, Eolia

AU - Bazarbachi, Ali

AU - Giebel, Sebastian

AU - Savani, Bipin P

AU - Nagler, Arnon

AU - Ciceri, Fabio

AU - Mohty, Mohamad

N1 - © 2023. The Author(s).

PY - 2024/2

Y1 - 2024/2

N2 - The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning intensity (TCI) score to stratify the preparative regimens of allo-HCT, we used an independent and contemporary patient cohort of 4060 transplant recipients with acute myeloid leukemia meeting inclusion criteria from the discovery study (allo-HCT in first complete remission, matched donor), but who were allografted in a more recent period (2018-2021) and were one decade older (55-75 years, median 63.4 years), we assigned them to a TCI category (low n = 1934, 48%; intermediate n = 1948, 48%, high n = 178, 4%) according to the calculated TCI score ([1-2], [2.5-3.5], [4-6], respectively), and examined the validity of the TCI category in predicting early non-relapse mortality (NRM), 2-year NRM and relapse (REL). In the unadjusted comparison, the TCI index provided a significant risk stratification for d100 and d180 NRM, NRM and REL risk. In the multivariate analysis adjusted for significant variables, there was an independent association of TCI with early NRM, NRM and REL. In summary, we confirm in contemporary treated patients that TCI reflects the conditioning regimen related morbidity and anti-leukemic efficacy satisfactorily and across other established prognostic factors.

AB - The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning intensity (TCI) score to stratify the preparative regimens of allo-HCT, we used an independent and contemporary patient cohort of 4060 transplant recipients with acute myeloid leukemia meeting inclusion criteria from the discovery study (allo-HCT in first complete remission, matched donor), but who were allografted in a more recent period (2018-2021) and were one decade older (55-75 years, median 63.4 years), we assigned them to a TCI category (low n = 1934, 48%; intermediate n = 1948, 48%, high n = 178, 4%) according to the calculated TCI score ([1-2], [2.5-3.5], [4-6], respectively), and examined the validity of the TCI category in predicting early non-relapse mortality (NRM), 2-year NRM and relapse (REL). In the unadjusted comparison, the TCI index provided a significant risk stratification for d100 and d180 NRM, NRM and REL risk. In the multivariate analysis adjusted for significant variables, there was an independent association of TCI with early NRM, NRM and REL. In summary, we confirm in contemporary treated patients that TCI reflects the conditioning regimen related morbidity and anti-leukemic efficacy satisfactorily and across other established prognostic factors.

U2 - 10.1038/s41409-023-02139-5

DO - 10.1038/s41409-023-02139-5

M3 - SCORING: Journal article

C2 - 37978322

VL - 59

SP - 217

EP - 223

JO - BONE MARROW TRANSPL

JF - BONE MARROW TRANSPL

SN - 0268-3369

IS - 2

ER -