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Vagus nerve inflammation contributes to dysautonomia in COVID-19

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Vagus nerve inflammation contributes to dysautonomia in COVID-19. / Woo, Marcel S; Shafiq, Mohsin; Fitzek, Antonia; Dottermusch, Matthias; Altmeppen, Hermann; Mohammadi, Behnam; Mayer, Christina; Bal, Lukas C; Raich, Lukas; Matschke, Jakob; Krasemann, Susanne; Pfefferle, Susanne; Brehm, Thomas Theo; Lütgehetmann, Marc; Schädler, Julia; Addo, Marylyn M; Schulze Zur Wiesch, Julian; Ondruschka, Benjamin; Friese, Manuel A; Glatzel, Markus.

In: ACTA NEUROPATHOL, Vol. 146, No. 3, 09.2023, p. 387-394.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Woo, MS, Shafiq, M, Fitzek, A, Dottermusch, M, Altmeppen, H, Mohammadi, B, Mayer, C, Bal, LC, Raich, L, Matschke, J, Krasemann, S, Pfefferle, S, Brehm, TT, Lütgehetmann, M, Schädler, J, Addo, MM, Schulze Zur Wiesch, J, Ondruschka, B, Friese, MA & Glatzel, M 2023, 'Vagus nerve inflammation contributes to dysautonomia in COVID-19', ACTA NEUROPATHOL, vol. 146, no. 3, pp. 387-394. https://doi.org/10.1007/s00401-023-02612-x

APA

Woo, M. S., Shafiq, M., Fitzek, A., Dottermusch, M., Altmeppen, H., Mohammadi, B., Mayer, C., Bal, L. C., Raich, L., Matschke, J., Krasemann, S., Pfefferle, S., Brehm, T. T., Lütgehetmann, M., Schädler, J., Addo, M. M., Schulze Zur Wiesch, J., Ondruschka, B., Friese, M. A., & Glatzel, M. (2023). Vagus nerve inflammation contributes to dysautonomia in COVID-19. ACTA NEUROPATHOL, 146(3), 387-394. https://doi.org/10.1007/s00401-023-02612-x

Vancouver

Woo MS, Shafiq M, Fitzek A, Dottermusch M, Altmeppen H, Mohammadi B et al. Vagus nerve inflammation contributes to dysautonomia in COVID-19. ACTA NEUROPATHOL. 2023 Sep;146(3):387-394. https://doi.org/10.1007/s00401-023-02612-x

Bibtex

@article{8e09cf96301b4158b76b43ce9d7362a6,
title = "Vagus nerve inflammation contributes to dysautonomia in COVID-19",
abstract = "Dysautonomia has substantially impacted acute COVID-19 severity as well as symptom burden after recovery from COVID-19 (long COVID), yet the underlying causes remain unknown. Here, we hypothesized that vagus nerves are affected in COVID-19 which might contribute to autonomic dysfunction. We performed a histopathological characterization of postmortem vagus nerves from COVID-19 patients and controls, and detected SARS-CoV-2 RNA together with inflammatory cell infiltration composed primarily of monocytes. Furthermore, we performed RNA sequencing which revealed a strong inflammatory response of neurons, endothelial cells, and Schwann cells which correlated with SARS-CoV-2 RNA load. Lastly, we screened a clinical cohort of 323 patients to detect a clinical phenotype of vagus nerve affection and found a decreased respiratory rate in non-survivors of critical COVID-19. Our data suggest that SARS-CoV-2 induces vagus nerve inflammation followed by autonomic dysfunction which contributes to critical disease courses and might contribute to dysautonomia observed in long COVID.",
author = "Woo, {Marcel S} and Mohsin Shafiq and Antonia Fitzek and Matthias Dottermusch and Hermann Altmeppen and Behnam Mohammadi and Christina Mayer and Bal, {Lukas C} and Lukas Raich and Jakob Matschke and Susanne Krasemann and Susanne Pfefferle and Brehm, {Thomas Theo} and Marc L{\"u}tgehetmann and Julia Sch{\"a}dler and Addo, {Marylyn M} and {Schulze Zur Wiesch}, Julian and Benjamin Ondruschka and Friese, {Manuel A} and Markus Glatzel",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = sep,
doi = "10.1007/s00401-023-02612-x",
language = "English",
volume = "146",
pages = "387--394",
journal = "ACTA NEUROPATHOL",
issn = "0001-6322",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Vagus nerve inflammation contributes to dysautonomia in COVID-19

AU - Woo, Marcel S

AU - Shafiq, Mohsin

AU - Fitzek, Antonia

AU - Dottermusch, Matthias

AU - Altmeppen, Hermann

AU - Mohammadi, Behnam

AU - Mayer, Christina

AU - Bal, Lukas C

AU - Raich, Lukas

AU - Matschke, Jakob

AU - Krasemann, Susanne

AU - Pfefferle, Susanne

AU - Brehm, Thomas Theo

AU - Lütgehetmann, Marc

AU - Schädler, Julia

AU - Addo, Marylyn M

AU - Schulze Zur Wiesch, Julian

AU - Ondruschka, Benjamin

AU - Friese, Manuel A

AU - Glatzel, Markus

N1 - © 2023. The Author(s).

PY - 2023/9

Y1 - 2023/9

N2 - Dysautonomia has substantially impacted acute COVID-19 severity as well as symptom burden after recovery from COVID-19 (long COVID), yet the underlying causes remain unknown. Here, we hypothesized that vagus nerves are affected in COVID-19 which might contribute to autonomic dysfunction. We performed a histopathological characterization of postmortem vagus nerves from COVID-19 patients and controls, and detected SARS-CoV-2 RNA together with inflammatory cell infiltration composed primarily of monocytes. Furthermore, we performed RNA sequencing which revealed a strong inflammatory response of neurons, endothelial cells, and Schwann cells which correlated with SARS-CoV-2 RNA load. Lastly, we screened a clinical cohort of 323 patients to detect a clinical phenotype of vagus nerve affection and found a decreased respiratory rate in non-survivors of critical COVID-19. Our data suggest that SARS-CoV-2 induces vagus nerve inflammation followed by autonomic dysfunction which contributes to critical disease courses and might contribute to dysautonomia observed in long COVID.

AB - Dysautonomia has substantially impacted acute COVID-19 severity as well as symptom burden after recovery from COVID-19 (long COVID), yet the underlying causes remain unknown. Here, we hypothesized that vagus nerves are affected in COVID-19 which might contribute to autonomic dysfunction. We performed a histopathological characterization of postmortem vagus nerves from COVID-19 patients and controls, and detected SARS-CoV-2 RNA together with inflammatory cell infiltration composed primarily of monocytes. Furthermore, we performed RNA sequencing which revealed a strong inflammatory response of neurons, endothelial cells, and Schwann cells which correlated with SARS-CoV-2 RNA load. Lastly, we screened a clinical cohort of 323 patients to detect a clinical phenotype of vagus nerve affection and found a decreased respiratory rate in non-survivors of critical COVID-19. Our data suggest that SARS-CoV-2 induces vagus nerve inflammation followed by autonomic dysfunction which contributes to critical disease courses and might contribute to dysautonomia observed in long COVID.

U2 - 10.1007/s00401-023-02612-x

DO - 10.1007/s00401-023-02612-x

M3 - SCORING: Journal article

C2 - 37452829

VL - 146

SP - 387

EP - 394

JO - ACTA NEUROPATHOL

JF - ACTA NEUROPATHOL

SN - 0001-6322

IS - 3

ER -