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Ultrastructural alterations of mitochondria in pre-apoptotic and apoptotic hepatocytes of TNF alpha-treated galactosamine-sensitized mice.

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Ultrastructural alterations of mitochondria in pre-apoptotic and apoptotic hepatocytes of TNF alpha-treated galactosamine-sensitized mice. / Angermüller, S; Schümann, J; Fahimi, H D; Tiegs, Gisa.

In: ANN NY ACAD SCI, Vol. 887, 1999, p. 12-17.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Angermüller, S, Schümann, J, Fahimi, HD & Tiegs, G 1999, 'Ultrastructural alterations of mitochondria in pre-apoptotic and apoptotic hepatocytes of TNF alpha-treated galactosamine-sensitized mice.', ANN NY ACAD SCI, vol. 887, pp. 12-17. <http://www.ncbi.nlm.nih.gov/pubmed/10668460?dopt=Citation>

APA

Angermüller, S., Schümann, J., Fahimi, H. D., & Tiegs, G. (1999). Ultrastructural alterations of mitochondria in pre-apoptotic and apoptotic hepatocytes of TNF alpha-treated galactosamine-sensitized mice. ANN NY ACAD SCI, 887, 12-17. http://www.ncbi.nlm.nih.gov/pubmed/10668460?dopt=Citation

Vancouver

Angermüller S, Schümann J, Fahimi HD, Tiegs G. Ultrastructural alterations of mitochondria in pre-apoptotic and apoptotic hepatocytes of TNF alpha-treated galactosamine-sensitized mice. ANN NY ACAD SCI. 1999;887:12-17.

Bibtex

@article{8f4720cce7a44f31a1fdf576d53768b6,
title = "Ultrastructural alterations of mitochondria in pre-apoptotic and apoptotic hepatocytes of TNF alpha-treated galactosamine-sensitized mice.",
abstract = "The electron microscopical studies presented here show that characteristic morphological alterations in mitochondria are a very early hallmark of the hepatocellular apoptotic program. Before chromatin condensation occurs, the outer mitochondrial membrane is focally disrupted and the inner membrane protrudes through this gap forming a hernia. The demonstration of cytochrome oxidase in mitochondria revealed a very strong activity in pre-apoptotic and apoptotic cells as well as in apoptotic bodies.",
keywords = "Animals, Mice, Galactosamine/*toxicity, Tumor Necrosis Factor-alpha/*pharmacology, Apoptosis/*drug effects, Liver/*drug effects/pathology/ultrastructure, Mitochondria, Liver/drug effects/*ultrastructure, Animals, Mice, Galactosamine/*toxicity, Tumor Necrosis Factor-alpha/*pharmacology, Apoptosis/*drug effects, Liver/*drug effects/pathology/ultrastructure, Mitochondria, Liver/drug effects/*ultrastructure",
author = "S Angerm{\"u}ller and J Sch{\"u}mann and Fahimi, {H D} and Gisa Tiegs",
year = "1999",
language = "English",
volume = "887",
pages = "12--17",
journal = "ANN NY ACAD SCI",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Ultrastructural alterations of mitochondria in pre-apoptotic and apoptotic hepatocytes of TNF alpha-treated galactosamine-sensitized mice.

AU - Angermüller, S

AU - Schümann, J

AU - Fahimi, H D

AU - Tiegs, Gisa

PY - 1999

Y1 - 1999

N2 - The electron microscopical studies presented here show that characteristic morphological alterations in mitochondria are a very early hallmark of the hepatocellular apoptotic program. Before chromatin condensation occurs, the outer mitochondrial membrane is focally disrupted and the inner membrane protrudes through this gap forming a hernia. The demonstration of cytochrome oxidase in mitochondria revealed a very strong activity in pre-apoptotic and apoptotic cells as well as in apoptotic bodies.

AB - The electron microscopical studies presented here show that characteristic morphological alterations in mitochondria are a very early hallmark of the hepatocellular apoptotic program. Before chromatin condensation occurs, the outer mitochondrial membrane is focally disrupted and the inner membrane protrudes through this gap forming a hernia. The demonstration of cytochrome oxidase in mitochondria revealed a very strong activity in pre-apoptotic and apoptotic cells as well as in apoptotic bodies.

KW - Animals

KW - Mice

KW - Galactosamine/toxicity

KW - Tumor Necrosis Factor-alpha/pharmacology

KW - Apoptosis/drug effects

KW - Liver/drug effects/pathology/ultrastructure

KW - Mitochondria, Liver/drug effects/ultrastructure

KW - Animals

KW - Mice

KW - Galactosamine/toxicity

KW - Tumor Necrosis Factor-alpha/pharmacology

KW - Apoptosis/drug effects

KW - Liver/drug effects/pathology/ultrastructure

KW - Mitochondria, Liver/drug effects/ultrastructure

M3 - SCORING: Journal article

VL - 887

SP - 12

EP - 17

JO - ANN NY ACAD SCI

JF - ANN NY ACAD SCI

SN - 0077-8923

ER -