Ultrastructural alterations of mitochondria in pre-apoptotic and apoptotic hepatocytes of TNF alpha-treated galactosamine-sensitized mice.
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Ultrastructural alterations of mitochondria in pre-apoptotic and apoptotic hepatocytes of TNF alpha-treated galactosamine-sensitized mice. / Angermüller, S; Schümann, J; Fahimi, H D; Tiegs, Gisa.
in: ANN NY ACAD SCI, Jahrgang 887, 1999, S. 12-17.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Ultrastructural alterations of mitochondria in pre-apoptotic and apoptotic hepatocytes of TNF alpha-treated galactosamine-sensitized mice.
AU - Angermüller, S
AU - Schümann, J
AU - Fahimi, H D
AU - Tiegs, Gisa
PY - 1999
Y1 - 1999
N2 - The electron microscopical studies presented here show that characteristic morphological alterations in mitochondria are a very early hallmark of the hepatocellular apoptotic program. Before chromatin condensation occurs, the outer mitochondrial membrane is focally disrupted and the inner membrane protrudes through this gap forming a hernia. The demonstration of cytochrome oxidase in mitochondria revealed a very strong activity in pre-apoptotic and apoptotic cells as well as in apoptotic bodies.
AB - The electron microscopical studies presented here show that characteristic morphological alterations in mitochondria are a very early hallmark of the hepatocellular apoptotic program. Before chromatin condensation occurs, the outer mitochondrial membrane is focally disrupted and the inner membrane protrudes through this gap forming a hernia. The demonstration of cytochrome oxidase in mitochondria revealed a very strong activity in pre-apoptotic and apoptotic cells as well as in apoptotic bodies.
KW - Animals
KW - Mice
KW - Galactosamine/toxicity
KW - Tumor Necrosis Factor-alpha/pharmacology
KW - Apoptosis/drug effects
KW - Liver/drug effects/pathology/ultrastructure
KW - Mitochondria, Liver/drug effects/ultrastructure
KW - Animals
KW - Mice
KW - Galactosamine/toxicity
KW - Tumor Necrosis Factor-alpha/pharmacology
KW - Apoptosis/drug effects
KW - Liver/drug effects/pathology/ultrastructure
KW - Mitochondria, Liver/drug effects/ultrastructure
M3 - SCORING: Journal article
VL - 887
SP - 12
EP - 17
JO - ANN NY ACAD SCI
JF - ANN NY ACAD SCI
SN - 0077-8923
ER -