Ultrafast extraction of proteins from tissues using desorption by impulsive vibrational excitation
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Ultrafast extraction of proteins from tissues using desorption by impulsive vibrational excitation. / Kwiatkowski, Marcel; Wurlitzer, Marcus; Omidi, Maryam; Ren, Ling; Kruber, Sebastian; Nimer, Refat; Robertson, Wesley D; Horst, Andrea; Miller, R J Dwayne; Schlüter, Hartmut.
In: ANGEW CHEM INT EDIT, Vol. 54, No. 1, 02.01.2015, p. 285-8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Ultrafast extraction of proteins from tissues using desorption by impulsive vibrational excitation
AU - Kwiatkowski, Marcel
AU - Wurlitzer, Marcus
AU - Omidi, Maryam
AU - Ren, Ling
AU - Kruber, Sebastian
AU - Nimer, Refat
AU - Robertson, Wesley D
AU - Horst, Andrea
AU - Miller, R J Dwayne
AU - Schlüter, Hartmut
N1 - © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2015/1/2
Y1 - 2015/1/2
N2 - A picosecond IR laser (PIRL) can be used to blast proteins out of tissues through desorption by impulsive excitation (DIVE) of intramolecular vibrational states of water molecules in the cell in less than a millisecond. With PIRL-DIVE proteins covering a range of a few kDa up to several MDa are extracted in high quantities compared to conventional approaches. The chemical composition of extracted proteins remains unaltered and even enzymatic activities are maintained.
AB - A picosecond IR laser (PIRL) can be used to blast proteins out of tissues through desorption by impulsive excitation (DIVE) of intramolecular vibrational states of water molecules in the cell in less than a millisecond. With PIRL-DIVE proteins covering a range of a few kDa up to several MDa are extracted in high quantities compared to conventional approaches. The chemical composition of extracted proteins remains unaltered and even enzymatic activities are maintained.
U2 - 10.1002/anie.201407669
DO - 10.1002/anie.201407669
M3 - SCORING: Journal article
C2 - 25346525
VL - 54
SP - 285
EP - 288
JO - ANGEW CHEM INT EDIT
JF - ANGEW CHEM INT EDIT
SN - 1433-7851
IS - 1
ER -