Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties
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Abstract
New asterosaponins archasterosides A (1), B (2), and the known regularoside A (3) were isolated from the Vietnamese starfish Archaster typicus and structurally elucidated by extensive NMR techniques and chemical transformations. Compounds 1-3 showed moderate cytotoxic activities against HeLa and mouse JB6 P+ Cl41 cell lines. The most active, 2, induced basal AP-1- and p53-, but not NF-κB-transcriptional activations in JB6 Cl41 cells.
Bibliographical data
Original language | English |
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ISSN | 0960-894X |
DOIs | |
Publication status | Published - 2010 |
Comment Deanary
Funding Information:
Financial support was provided by Program of RAS ‘Molecular and Cell Biology’ (MCB RAS) , Grant 09-04-90308-Viet_a from the RFBR , the Vietnam 01-672/QD-KHCNVN Project, FEB RAS Grants 10-III-B-05-018 , 09-III-A-05-146 . The authors are grateful to Dr. Do Cong Thung, VAST, for the identification of the starfish.
Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.