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Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis

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Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis. / Brinkert, Florian; Arrenberg, Philomena; Krech, Till; Grabhorn, Enke; Lohse, Ansgar; Schramm, Christoph.

In: PEDIATRICS, Vol. 138, No. 3, 09.2016, p. e20154245.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Brinkert, F, Arrenberg, P, Krech, T, Grabhorn, E, Lohse, A & Schramm, C 2016, 'Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis', PEDIATRICS, vol. 138, no. 3, pp. e20154245. https://doi.org/10.1542/peds.2015-4245

APA

Brinkert, F., Arrenberg, P., Krech, T., Grabhorn, E., Lohse, A., & Schramm, C. (2016). Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis. PEDIATRICS, 138(3), e20154245. https://doi.org/10.1542/peds.2015-4245

Vancouver

Brinkert F, Arrenberg P, Krech T, Grabhorn E, Lohse A, Schramm C. Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis. PEDIATRICS. 2016 Sep;138(3):e20154245. https://doi.org/10.1542/peds.2015-4245

Bibtex

@article{dad76e2841f74fcdb5d6078be00db63b,
title = "Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis",
abstract = "We report the first 2 cases of hepatosplenic T-cell lymphoma in adolescents diagnosed with autoimmune hepatitis under long-term treatment with azathioprine. Patients presented with fatigue, hepatosplenomegaly, and pancytopenia. The diagnosis could be confirmed performing biopsies of liver and spleen or bone marrow, which demonstrated infiltration of neoplastic T lymphocytes with the typical phenotype with both markers, CD56(+) and TCRγδ(+) Thus, these cases emphasize the need to constantly reevaluate the administered dose and duration of thiopurines for autoimmune hepatitis, especially in adolescents.",
keywords = "Journal Article",
author = "Florian Brinkert and Philomena Arrenberg and Till Krech and Enke Grabhorn and Ansgar Lohse and Christoph Schramm",
note = "Copyright {\textcopyright} 2016 by the American Academy of Pediatrics.",
year = "2016",
month = sep,
doi = "10.1542/peds.2015-4245",
language = "English",
volume = "138",
pages = "e20154245",
journal = "PEDIATRICS",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "3",

}

RIS

TY - JOUR

T1 - Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis

AU - Brinkert, Florian

AU - Arrenberg, Philomena

AU - Krech, Till

AU - Grabhorn, Enke

AU - Lohse, Ansgar

AU - Schramm, Christoph

N1 - Copyright © 2016 by the American Academy of Pediatrics.

PY - 2016/9

Y1 - 2016/9

N2 - We report the first 2 cases of hepatosplenic T-cell lymphoma in adolescents diagnosed with autoimmune hepatitis under long-term treatment with azathioprine. Patients presented with fatigue, hepatosplenomegaly, and pancytopenia. The diagnosis could be confirmed performing biopsies of liver and spleen or bone marrow, which demonstrated infiltration of neoplastic T lymphocytes with the typical phenotype with both markers, CD56(+) and TCRγδ(+) Thus, these cases emphasize the need to constantly reevaluate the administered dose and duration of thiopurines for autoimmune hepatitis, especially in adolescents.

AB - We report the first 2 cases of hepatosplenic T-cell lymphoma in adolescents diagnosed with autoimmune hepatitis under long-term treatment with azathioprine. Patients presented with fatigue, hepatosplenomegaly, and pancytopenia. The diagnosis could be confirmed performing biopsies of liver and spleen or bone marrow, which demonstrated infiltration of neoplastic T lymphocytes with the typical phenotype with both markers, CD56(+) and TCRγδ(+) Thus, these cases emphasize the need to constantly reevaluate the administered dose and duration of thiopurines for autoimmune hepatitis, especially in adolescents.

KW - Journal Article

U2 - 10.1542/peds.2015-4245

DO - 10.1542/peds.2015-4245

M3 - SCORING: Journal article

C2 - 27516526

VL - 138

SP - e20154245

JO - PEDIATRICS

JF - PEDIATRICS

SN - 0031-4005

IS - 3

ER -