Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis
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Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis. / Brinkert, Florian; Arrenberg, Philomena; Krech, Till; Grabhorn, Enke; Lohse, Ansgar; Schramm, Christoph.
in: PEDIATRICS, Jahrgang 138, Nr. 3, 09.2016, S. e20154245.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis
AU - Brinkert, Florian
AU - Arrenberg, Philomena
AU - Krech, Till
AU - Grabhorn, Enke
AU - Lohse, Ansgar
AU - Schramm, Christoph
N1 - Copyright © 2016 by the American Academy of Pediatrics.
PY - 2016/9
Y1 - 2016/9
N2 - We report the first 2 cases of hepatosplenic T-cell lymphoma in adolescents diagnosed with autoimmune hepatitis under long-term treatment with azathioprine. Patients presented with fatigue, hepatosplenomegaly, and pancytopenia. The diagnosis could be confirmed performing biopsies of liver and spleen or bone marrow, which demonstrated infiltration of neoplastic T lymphocytes with the typical phenotype with both markers, CD56(+) and TCRγδ(+) Thus, these cases emphasize the need to constantly reevaluate the administered dose and duration of thiopurines for autoimmune hepatitis, especially in adolescents.
AB - We report the first 2 cases of hepatosplenic T-cell lymphoma in adolescents diagnosed with autoimmune hepatitis under long-term treatment with azathioprine. Patients presented with fatigue, hepatosplenomegaly, and pancytopenia. The diagnosis could be confirmed performing biopsies of liver and spleen or bone marrow, which demonstrated infiltration of neoplastic T lymphocytes with the typical phenotype with both markers, CD56(+) and TCRγδ(+) Thus, these cases emphasize the need to constantly reevaluate the administered dose and duration of thiopurines for autoimmune hepatitis, especially in adolescents.
KW - Journal Article
U2 - 10.1542/peds.2015-4245
DO - 10.1542/peds.2015-4245
M3 - SCORING: Journal article
C2 - 27516526
VL - 138
SP - e20154245
JO - PEDIATRICS
JF - PEDIATRICS
SN - 0031-4005
IS - 3
ER -