Tumor metastasis: moving new biological insights into the clinic
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Tumor metastasis: moving new biological insights into the clinic. / Wan, Liling; Pantel, Klaus; Kang, Yibin.
In: NAT MED, Vol. 19, No. 11, 01.11.2013, p. 1450-64.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Tumor metastasis: moving new biological insights into the clinic
AU - Wan, Liling
AU - Pantel, Klaus
AU - Kang, Yibin
PY - 2013/11/1
Y1 - 2013/11/1
N2 - As the culprit behind most cancer-related deaths, metastasis is the ultimate challenge in our effort to fight cancer as a life-threatening disease. The explosive growth of metastasis research in the past decade has yielded an unprecedented wealth of information about the tumor-intrinsic and tumor-extrinsic mechanisms that dictate metastatic behaviors, the molecular and cellular basis underlying the distinct courses of metastatic progression in different cancers and what renders metastatic cancer refractory to available therapies. However, integration of such new knowledge into an improved, metastasis-oriented oncological drug development strategy is needed to thwart the development of metastatic disease at every stage of progression.
AB - As the culprit behind most cancer-related deaths, metastasis is the ultimate challenge in our effort to fight cancer as a life-threatening disease. The explosive growth of metastasis research in the past decade has yielded an unprecedented wealth of information about the tumor-intrinsic and tumor-extrinsic mechanisms that dictate metastatic behaviors, the molecular and cellular basis underlying the distinct courses of metastatic progression in different cancers and what renders metastatic cancer refractory to available therapies. However, integration of such new knowledge into an improved, metastasis-oriented oncological drug development strategy is needed to thwart the development of metastatic disease at every stage of progression.
KW - Cell Survival
KW - Drug Discovery
KW - Epithelial-Mesenchymal Transition
KW - Humans
KW - Models, Biological
KW - Mutation
KW - Neoplasm Invasiveness
KW - Neoplasm Metastasis
KW - Oncogenes
KW - Stromal Cells
KW - Translational Medical Research
KW - Tumor Microenvironment
U2 - 10.1038/nm.3391
DO - 10.1038/nm.3391
M3 - SCORING: Journal article
C2 - 24202397
VL - 19
SP - 1450
EP - 1464
JO - NAT MED
JF - NAT MED
SN - 1078-8956
IS - 11
ER -