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Tumor metastasis: moving new biological insights into the clinic

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Tumor metastasis: moving new biological insights into the clinic. / Wan, Liling; Pantel, Klaus; Kang, Yibin.

in: NAT MED, Jahrgang 19, Nr. 11, 01.11.2013, S. 1450-64.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wan, L, Pantel, K & Kang, Y 2013, 'Tumor metastasis: moving new biological insights into the clinic', NAT MED, Jg. 19, Nr. 11, S. 1450-64. https://doi.org/10.1038/nm.3391

APA

Wan, L., Pantel, K., & Kang, Y. (2013). Tumor metastasis: moving new biological insights into the clinic. NAT MED, 19(11), 1450-64. https://doi.org/10.1038/nm.3391

Vancouver

Wan L, Pantel K, Kang Y. Tumor metastasis: moving new biological insights into the clinic. NAT MED. 2013 Nov 1;19(11):1450-64. https://doi.org/10.1038/nm.3391

Bibtex

@article{1d8ce8760a33426398026311ef65f0dc,
title = "Tumor metastasis: moving new biological insights into the clinic",
abstract = "As the culprit behind most cancer-related deaths, metastasis is the ultimate challenge in our effort to fight cancer as a life-threatening disease. The explosive growth of metastasis research in the past decade has yielded an unprecedented wealth of information about the tumor-intrinsic and tumor-extrinsic mechanisms that dictate metastatic behaviors, the molecular and cellular basis underlying the distinct courses of metastatic progression in different cancers and what renders metastatic cancer refractory to available therapies. However, integration of such new knowledge into an improved, metastasis-oriented oncological drug development strategy is needed to thwart the development of metastatic disease at every stage of progression.",
keywords = "Cell Survival, Drug Discovery, Epithelial-Mesenchymal Transition, Humans, Models, Biological, Mutation, Neoplasm Invasiveness, Neoplasm Metastasis, Oncogenes, Stromal Cells, Translational Medical Research, Tumor Microenvironment",
author = "Liling Wan and Klaus Pantel and Yibin Kang",
year = "2013",
month = nov,
day = "1",
doi = "10.1038/nm.3391",
language = "English",
volume = "19",
pages = "1450--64",
journal = "NAT MED",
issn = "1078-8956",
publisher = "NATURE PUBLISHING GROUP",
number = "11",

}

RIS

TY - JOUR

T1 - Tumor metastasis: moving new biological insights into the clinic

AU - Wan, Liling

AU - Pantel, Klaus

AU - Kang, Yibin

PY - 2013/11/1

Y1 - 2013/11/1

N2 - As the culprit behind most cancer-related deaths, metastasis is the ultimate challenge in our effort to fight cancer as a life-threatening disease. The explosive growth of metastasis research in the past decade has yielded an unprecedented wealth of information about the tumor-intrinsic and tumor-extrinsic mechanisms that dictate metastatic behaviors, the molecular and cellular basis underlying the distinct courses of metastatic progression in different cancers and what renders metastatic cancer refractory to available therapies. However, integration of such new knowledge into an improved, metastasis-oriented oncological drug development strategy is needed to thwart the development of metastatic disease at every stage of progression.

AB - As the culprit behind most cancer-related deaths, metastasis is the ultimate challenge in our effort to fight cancer as a life-threatening disease. The explosive growth of metastasis research in the past decade has yielded an unprecedented wealth of information about the tumor-intrinsic and tumor-extrinsic mechanisms that dictate metastatic behaviors, the molecular and cellular basis underlying the distinct courses of metastatic progression in different cancers and what renders metastatic cancer refractory to available therapies. However, integration of such new knowledge into an improved, metastasis-oriented oncological drug development strategy is needed to thwart the development of metastatic disease at every stage of progression.

KW - Cell Survival

KW - Drug Discovery

KW - Epithelial-Mesenchymal Transition

KW - Humans

KW - Models, Biological

KW - Mutation

KW - Neoplasm Invasiveness

KW - Neoplasm Metastasis

KW - Oncogenes

KW - Stromal Cells

KW - Translational Medical Research

KW - Tumor Microenvironment

U2 - 10.1038/nm.3391

DO - 10.1038/nm.3391

M3 - SCORING: Journal article

C2 - 24202397

VL - 19

SP - 1450

EP - 1464

JO - NAT MED

JF - NAT MED

SN - 1078-8956

IS - 11

ER -