Tumor cell dissemination: emerging biological insights from animal models and cancer patients
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Tumor cell dissemination: emerging biological insights from animal models and cancer patients. / Kang, Yibin; Pantel, Klaus.
In: CANCER CELL, Vol. 23, No. 5, 13.05.2013, p. 573-81.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Tumor cell dissemination: emerging biological insights from animal models and cancer patients
AU - Kang, Yibin
AU - Pantel, Klaus
N1 - Copyright © 2013 Elsevier Inc. All rights reserved.
PY - 2013/5/13
Y1 - 2013/5/13
N2 - Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are increasingly recognized for their potential utility in disease monitoring and therapeutic targeting. The clinical application of CTC/DTC requires better understanding of the biological mechanisms behind tumor dissemination, the survival of DTCs, and their activation to aggressive growth from dormancy. Recent research using animal models of DTCs and CTCs have provided novel insights into these processes. Here, we discuss these findings in the context of results obtained from the clinical analyses of CTCs and DTCs, which demonstrate that the animal models mimic, in many aspects, the complex situation in patients.
AB - Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are increasingly recognized for their potential utility in disease monitoring and therapeutic targeting. The clinical application of CTC/DTC requires better understanding of the biological mechanisms behind tumor dissemination, the survival of DTCs, and their activation to aggressive growth from dormancy. Recent research using animal models of DTCs and CTCs have provided novel insights into these processes. Here, we discuss these findings in the context of results obtained from the clinical analyses of CTCs and DTCs, which demonstrate that the animal models mimic, in many aspects, the complex situation in patients.
KW - Animals
KW - Cell Survival
KW - Disease Models, Animal
KW - Epithelial-Mesenchymal Transition
KW - Humans
KW - Mice
KW - Neoplasm Invasiveness
KW - Neoplasm Metastasis
KW - Neoplastic Cells, Circulating
U2 - 10.1016/j.ccr.2013.04.017
DO - 10.1016/j.ccr.2013.04.017
M3 - SCORING: Journal article
C2 - 23680145
VL - 23
SP - 573
EP - 581
JO - CANCER CELL
JF - CANCER CELL
SN - 1535-6108
IS - 5
ER -