Tumor cell dissemination: emerging biological insights from animal models and cancer patients

Yibin Kang; Klaus Pantel

doi:10.1016/j.ccr.2013.04.017

Tumor cell dissemination: emerging biological insights from animal models and cancer patients

Standard

Tumor cell dissemination: emerging biological insights from animal models and cancer patients. / Kang, Yibin; Pantel, Klaus.

in: CANCER CELL, Jahrgang 23, Nr. 5, 13.05.2013, S. 573-81.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kang, Y & Pantel, K 2013, 'Tumor cell dissemination: emerging biological insights from animal models and cancer patients', CANCER CELL, Jg. 23, Nr. 5, S. 573-81. https://doi.org/10.1016/j.ccr.2013.04.017

APA

Kang, Y., & Pantel, K. (2013). Tumor cell dissemination: emerging biological insights from animal models and cancer patients. CANCER CELL, 23(5), 573-81. https://doi.org/10.1016/j.ccr.2013.04.017

Vancouver

Kang Y, Pantel K. Tumor cell dissemination: emerging biological insights from animal models and cancer patients. CANCER CELL. 2013 Mai 13;23(5):573-81. https://doi.org/10.1016/j.ccr.2013.04.017

Bibtex

@article{4e03fd28ea79443693f224b295d03ca1,

title = "Tumor cell dissemination: emerging biological insights from animal models and cancer patients",

abstract = "Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are increasingly recognized for their potential utility in disease monitoring and therapeutic targeting. The clinical application of CTC/DTC requires better understanding of the biological mechanisms behind tumor dissemination, the survival of DTCs, and their activation to aggressive growth from dormancy. Recent research using animal models of DTCs and CTCs have provided novel insights into these processes. Here, we discuss these findings in the context of results obtained from the clinical analyses of CTCs and DTCs, which demonstrate that the animal models mimic, in many aspects, the complex situation in patients.",

keywords = "Animals, Cell Survival, Disease Models, Animal, Epithelial-Mesenchymal Transition, Humans, Mice, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplastic Cells, Circulating",

author = "Yibin Kang and Klaus Pantel",

year = "2013",

month = may,

day = "13",

doi = "10.1016/j.ccr.2013.04.017",

language = "English",

volume = "23",

pages = "573--81",

journal = "CANCER CELL",

issn = "1535-6108",

publisher = "Cell Press",

number = "5",

}

RIS

TY - JOUR

T1 - Tumor cell dissemination: emerging biological insights from animal models and cancer patients

AU - Kang, Yibin

AU - Pantel, Klaus

PY - 2013/5/13

Y1 - 2013/5/13

N2 - Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are increasingly recognized for their potential utility in disease monitoring and therapeutic targeting. The clinical application of CTC/DTC requires better understanding of the biological mechanisms behind tumor dissemination, the survival of DTCs, and their activation to aggressive growth from dormancy. Recent research using animal models of DTCs and CTCs have provided novel insights into these processes. Here, we discuss these findings in the context of results obtained from the clinical analyses of CTCs and DTCs, which demonstrate that the animal models mimic, in many aspects, the complex situation in patients.

AB - Circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) are increasingly recognized for their potential utility in disease monitoring and therapeutic targeting. The clinical application of CTC/DTC requires better understanding of the biological mechanisms behind tumor dissemination, the survival of DTCs, and their activation to aggressive growth from dormancy. Recent research using animal models of DTCs and CTCs have provided novel insights into these processes. Here, we discuss these findings in the context of results obtained from the clinical analyses of CTCs and DTCs, which demonstrate that the animal models mimic, in many aspects, the complex situation in patients.

KW - Animals

KW - Cell Survival

KW - Disease Models, Animal

KW - Epithelial-Mesenchymal Transition

KW - Humans

KW - Mice

KW - Neoplasm Invasiveness

KW - Neoplasm Metastasis

KW - Neoplastic Cells, Circulating

U2 - 10.1016/j.ccr.2013.04.017

DO - 10.1016/j.ccr.2013.04.017

M3 - SCORING: Journal article

C2 - 23680145

VL - 23

SP - 573

EP - 581

JO - CANCER CELL

JF - CANCER CELL

SN - 1535-6108

IS - 5

ER -