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Triterpenes for Well-Balanced Scar Formation in Superficial Wounds

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Triterpenes for Well-Balanced Scar Formation in Superficial Wounds. / Kindler, Stefan; Schuster, Matthias; Seebauer, Christian; Rutkowski, Rico; Hauschild, Anna; Podmelle, Fred; Metelmann, Camilla; Metelmann, Bibiana; Müller-Debus, Charlotte; Metelmann, Hans-Robert; Metelmann, Isabella.

In: MOLECULES, Vol. 21, No. 9, 27.08.2016.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kindler, S, Schuster, M, Seebauer, C, Rutkowski, R, Hauschild, A, Podmelle, F, Metelmann, C, Metelmann, B, Müller-Debus, C, Metelmann, H-R & Metelmann, I 2016, 'Triterpenes for Well-Balanced Scar Formation in Superficial Wounds', MOLECULES, vol. 21, no. 9. https://doi.org/10.3390/molecules21091129

APA

Kindler, S., Schuster, M., Seebauer, C., Rutkowski, R., Hauschild, A., Podmelle, F., Metelmann, C., Metelmann, B., Müller-Debus, C., Metelmann, H-R., & Metelmann, I. (2016). Triterpenes for Well-Balanced Scar Formation in Superficial Wounds. MOLECULES, 21(9). https://doi.org/10.3390/molecules21091129

Vancouver

Kindler S, Schuster M, Seebauer C, Rutkowski R, Hauschild A, Podmelle F et al. Triterpenes for Well-Balanced Scar Formation in Superficial Wounds. MOLECULES. 2016 Aug 27;21(9). https://doi.org/10.3390/molecules21091129

Bibtex

@article{58b791e9263b43bea9620bb59c2faec0,
title = "Triterpenes for Well-Balanced Scar Formation in Superficial Wounds",
abstract = "Triterpenes are demonstrably effective for accelerating re-epithelialisation of wounds and known to improve scar formation for superficial lesions. Among the variety of triterpenes, betuline is of particular medical interest. Topical betuline gel (TBG) received drug approval in 2016 from the European Commission as the first topical therapeutic agent with the proven clinical benefit of accelerating wound healing. Two self-conducted randomized intra-individual comparison clinical studies with a total of 220 patients involved in TBG treatment of skin graft surgical wounds have been screened for data concerning the aesthetic aspect of wound healing. Three months after surgery wound treatment with TBG resulted in about 30% of cases with more discreet scars, and standard of care in about 10%. Patients themselves appreciate the results of TBG after 3 months even more (about 50%) compared to standard of care (about 10%). One year after surgery, the superiority of TBG counts for about 25% in comparison with about 10%, and from the patients' point of view, for 25% compared to 4% under standard of care. In the majority of wound treatment cases, there is no difference visible between TBG treatment and standard of care after 1 year of scar formation. However, in comparison, TBG still offers a better chance for discreet scars and therefore happens to be superior in good care of wounds. ",
keywords = "Administration, Topical, Cicatrix/drug therapy, Female, Humans, Male, Surgical Wound/drug therapy, Triterpenes/administration & dosage, Wound Healing/drug effects",
author = "Stefan Kindler and Matthias Schuster and Christian Seebauer and Rico Rutkowski and Anna Hauschild and Fred Podmelle and Camilla Metelmann and Bibiana Metelmann and Charlotte M{\"u}ller-Debus and Hans-Robert Metelmann and Isabella Metelmann",
year = "2016",
month = aug,
day = "27",
doi = "10.3390/molecules21091129",
language = "English",
volume = "21",
journal = "MOLECULES",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "9",

}

RIS

TY - JOUR

T1 - Triterpenes for Well-Balanced Scar Formation in Superficial Wounds

AU - Kindler, Stefan

AU - Schuster, Matthias

AU - Seebauer, Christian

AU - Rutkowski, Rico

AU - Hauschild, Anna

AU - Podmelle, Fred

AU - Metelmann, Camilla

AU - Metelmann, Bibiana

AU - Müller-Debus, Charlotte

AU - Metelmann, Hans-Robert

AU - Metelmann, Isabella

PY - 2016/8/27

Y1 - 2016/8/27

N2 - Triterpenes are demonstrably effective for accelerating re-epithelialisation of wounds and known to improve scar formation for superficial lesions. Among the variety of triterpenes, betuline is of particular medical interest. Topical betuline gel (TBG) received drug approval in 2016 from the European Commission as the first topical therapeutic agent with the proven clinical benefit of accelerating wound healing. Two self-conducted randomized intra-individual comparison clinical studies with a total of 220 patients involved in TBG treatment of skin graft surgical wounds have been screened for data concerning the aesthetic aspect of wound healing. Three months after surgery wound treatment with TBG resulted in about 30% of cases with more discreet scars, and standard of care in about 10%. Patients themselves appreciate the results of TBG after 3 months even more (about 50%) compared to standard of care (about 10%). One year after surgery, the superiority of TBG counts for about 25% in comparison with about 10%, and from the patients' point of view, for 25% compared to 4% under standard of care. In the majority of wound treatment cases, there is no difference visible between TBG treatment and standard of care after 1 year of scar formation. However, in comparison, TBG still offers a better chance for discreet scars and therefore happens to be superior in good care of wounds.

AB - Triterpenes are demonstrably effective for accelerating re-epithelialisation of wounds and known to improve scar formation for superficial lesions. Among the variety of triterpenes, betuline is of particular medical interest. Topical betuline gel (TBG) received drug approval in 2016 from the European Commission as the first topical therapeutic agent with the proven clinical benefit of accelerating wound healing. Two self-conducted randomized intra-individual comparison clinical studies with a total of 220 patients involved in TBG treatment of skin graft surgical wounds have been screened for data concerning the aesthetic aspect of wound healing. Three months after surgery wound treatment with TBG resulted in about 30% of cases with more discreet scars, and standard of care in about 10%. Patients themselves appreciate the results of TBG after 3 months even more (about 50%) compared to standard of care (about 10%). One year after surgery, the superiority of TBG counts for about 25% in comparison with about 10%, and from the patients' point of view, for 25% compared to 4% under standard of care. In the majority of wound treatment cases, there is no difference visible between TBG treatment and standard of care after 1 year of scar formation. However, in comparison, TBG still offers a better chance for discreet scars and therefore happens to be superior in good care of wounds.

KW - Administration, Topical

KW - Cicatrix/drug therapy

KW - Female

KW - Humans

KW - Male

KW - Surgical Wound/drug therapy

KW - Triterpenes/administration & dosage

KW - Wound Healing/drug effects

U2 - 10.3390/molecules21091129

DO - 10.3390/molecules21091129

M3 - SCORING: Journal article

C2 - 27618886

VL - 21

JO - MOLECULES

JF - MOLECULES

SN - 1420-3049

IS - 9

ER -