Triterpenes for Well-Balanced Scar Formation in Superficial Wounds
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Triterpenes for Well-Balanced Scar Formation in Superficial Wounds. / Kindler, Stefan; Schuster, Matthias; Seebauer, Christian; Rutkowski, Rico; Hauschild, Anna; Podmelle, Fred; Metelmann, Camilla; Metelmann, Bibiana; Müller-Debus, Charlotte; Metelmann, Hans-Robert; Metelmann, Isabella.
in: MOLECULES, Jahrgang 21, Nr. 9, 27.08.2016.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Triterpenes for Well-Balanced Scar Formation in Superficial Wounds
AU - Kindler, Stefan
AU - Schuster, Matthias
AU - Seebauer, Christian
AU - Rutkowski, Rico
AU - Hauschild, Anna
AU - Podmelle, Fred
AU - Metelmann, Camilla
AU - Metelmann, Bibiana
AU - Müller-Debus, Charlotte
AU - Metelmann, Hans-Robert
AU - Metelmann, Isabella
PY - 2016/8/27
Y1 - 2016/8/27
N2 - Triterpenes are demonstrably effective for accelerating re-epithelialisation of wounds and known to improve scar formation for superficial lesions. Among the variety of triterpenes, betuline is of particular medical interest. Topical betuline gel (TBG) received drug approval in 2016 from the European Commission as the first topical therapeutic agent with the proven clinical benefit of accelerating wound healing. Two self-conducted randomized intra-individual comparison clinical studies with a total of 220 patients involved in TBG treatment of skin graft surgical wounds have been screened for data concerning the aesthetic aspect of wound healing. Three months after surgery wound treatment with TBG resulted in about 30% of cases with more discreet scars, and standard of care in about 10%. Patients themselves appreciate the results of TBG after 3 months even more (about 50%) compared to standard of care (about 10%). One year after surgery, the superiority of TBG counts for about 25% in comparison with about 10%, and from the patients' point of view, for 25% compared to 4% under standard of care. In the majority of wound treatment cases, there is no difference visible between TBG treatment and standard of care after 1 year of scar formation. However, in comparison, TBG still offers a better chance for discreet scars and therefore happens to be superior in good care of wounds.
AB - Triterpenes are demonstrably effective for accelerating re-epithelialisation of wounds and known to improve scar formation for superficial lesions. Among the variety of triterpenes, betuline is of particular medical interest. Topical betuline gel (TBG) received drug approval in 2016 from the European Commission as the first topical therapeutic agent with the proven clinical benefit of accelerating wound healing. Two self-conducted randomized intra-individual comparison clinical studies with a total of 220 patients involved in TBG treatment of skin graft surgical wounds have been screened for data concerning the aesthetic aspect of wound healing. Three months after surgery wound treatment with TBG resulted in about 30% of cases with more discreet scars, and standard of care in about 10%. Patients themselves appreciate the results of TBG after 3 months even more (about 50%) compared to standard of care (about 10%). One year after surgery, the superiority of TBG counts for about 25% in comparison with about 10%, and from the patients' point of view, for 25% compared to 4% under standard of care. In the majority of wound treatment cases, there is no difference visible between TBG treatment and standard of care after 1 year of scar formation. However, in comparison, TBG still offers a better chance for discreet scars and therefore happens to be superior in good care of wounds.
KW - Administration, Topical
KW - Cicatrix/drug therapy
KW - Female
KW - Humans
KW - Male
KW - Surgical Wound/drug therapy
KW - Triterpenes/administration & dosage
KW - Wound Healing/drug effects
U2 - 10.3390/molecules21091129
DO - 10.3390/molecules21091129
M3 - SCORING: Journal article
C2 - 27618886
VL - 21
JO - MOLECULES
JF - MOLECULES
SN - 1420-3049
IS - 9
ER -