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Traumatic and nontraumatic spinal cord injury

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Traumatic and nontraumatic spinal cord injury : pathological insights from neuroimaging. / David, Gergely; Mohammadi, Siawoosh; Martin, Allan R; Cohen-Adad, Julien; Weiskopf, Nikolaus; Thompson, Alan; Freund, Patrick.

In: NAT REV NEUROL, Vol. 15, No. 12, 12.2019, p. 718-731.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

David, G, Mohammadi, S, Martin, AR, Cohen-Adad, J, Weiskopf, N, Thompson, A & Freund, P 2019, 'Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging', NAT REV NEUROL, vol. 15, no. 12, pp. 718-731. https://doi.org/10.1038/s41582-019-0270-5

APA

David, G., Mohammadi, S., Martin, A. R., Cohen-Adad, J., Weiskopf, N., Thompson, A., & Freund, P. (2019). Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging. NAT REV NEUROL, 15(12), 718-731. https://doi.org/10.1038/s41582-019-0270-5

Vancouver

David G, Mohammadi S, Martin AR, Cohen-Adad J, Weiskopf N, Thompson A et al. Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging. NAT REV NEUROL. 2019 Dec;15(12):718-731. https://doi.org/10.1038/s41582-019-0270-5

Bibtex

@article{dce77d0986b049ef88c8b17a95d837e9,
title = "Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging",
abstract = "Pathophysiological changes in the spinal cord white and grey matter resulting from injury can be observed with MRI techniques. These techniques provide sensitive markers of macrostructural and microstructural tissue integrity, which correlate with histological findings. Spinal cord MRI findings in traumatic spinal cord injury (tSCI) and nontraumatic spinal cord injury - the most common form of which is degenerative cervical myelopathy (DCM) - have provided important insights into the pathophysiological processes taking place not just at the focal injury site but also rostral and caudal to the spinal injury. Although tSCI and DCM have different aetiologies, they show similar degrees of spinal cord pathology remote from the injury site, suggesting the involvement of similar secondary degenerative mechanisms. Advanced quantitative MRI protocols that are sensitive to spinal cord pathology have the potential to improve diagnosis and, more importantly, predict outcomes in patients with tSCI or nontraumatic spinal cord injury. This Review describes the insights into tSCI and DCM that have been revealed by neuroimaging and outlines current activities and future directions for the field.",
keywords = "Diffusion Tensor Imaging/methods, Humans, Magnetic Resonance Imaging/methods, Neuroimaging/methods, Spinal Cord Injuries/diagnostic imaging",
author = "Gergely David and Siawoosh Mohammadi and Martin, {Allan R} and Julien Cohen-Adad and Nikolaus Weiskopf and Alan Thompson and Patrick Freund",
year = "2019",
month = dec,
doi = "10.1038/s41582-019-0270-5",
language = "English",
volume = "15",
pages = "718--731",
journal = "NAT REV NEUROL",
issn = "1759-4758",
publisher = "NATURE PUBLISHING GROUP",
number = "12",

}

RIS

TY - JOUR

T1 - Traumatic and nontraumatic spinal cord injury

T2 - pathological insights from neuroimaging

AU - David, Gergely

AU - Mohammadi, Siawoosh

AU - Martin, Allan R

AU - Cohen-Adad, Julien

AU - Weiskopf, Nikolaus

AU - Thompson, Alan

AU - Freund, Patrick

PY - 2019/12

Y1 - 2019/12

N2 - Pathophysiological changes in the spinal cord white and grey matter resulting from injury can be observed with MRI techniques. These techniques provide sensitive markers of macrostructural and microstructural tissue integrity, which correlate with histological findings. Spinal cord MRI findings in traumatic spinal cord injury (tSCI) and nontraumatic spinal cord injury - the most common form of which is degenerative cervical myelopathy (DCM) - have provided important insights into the pathophysiological processes taking place not just at the focal injury site but also rostral and caudal to the spinal injury. Although tSCI and DCM have different aetiologies, they show similar degrees of spinal cord pathology remote from the injury site, suggesting the involvement of similar secondary degenerative mechanisms. Advanced quantitative MRI protocols that are sensitive to spinal cord pathology have the potential to improve diagnosis and, more importantly, predict outcomes in patients with tSCI or nontraumatic spinal cord injury. This Review describes the insights into tSCI and DCM that have been revealed by neuroimaging and outlines current activities and future directions for the field.

AB - Pathophysiological changes in the spinal cord white and grey matter resulting from injury can be observed with MRI techniques. These techniques provide sensitive markers of macrostructural and microstructural tissue integrity, which correlate with histological findings. Spinal cord MRI findings in traumatic spinal cord injury (tSCI) and nontraumatic spinal cord injury - the most common form of which is degenerative cervical myelopathy (DCM) - have provided important insights into the pathophysiological processes taking place not just at the focal injury site but also rostral and caudal to the spinal injury. Although tSCI and DCM have different aetiologies, they show similar degrees of spinal cord pathology remote from the injury site, suggesting the involvement of similar secondary degenerative mechanisms. Advanced quantitative MRI protocols that are sensitive to spinal cord pathology have the potential to improve diagnosis and, more importantly, predict outcomes in patients with tSCI or nontraumatic spinal cord injury. This Review describes the insights into tSCI and DCM that have been revealed by neuroimaging and outlines current activities and future directions for the field.

KW - Diffusion Tensor Imaging/methods

KW - Humans

KW - Magnetic Resonance Imaging/methods

KW - Neuroimaging/methods

KW - Spinal Cord Injuries/diagnostic imaging

U2 - 10.1038/s41582-019-0270-5

DO - 10.1038/s41582-019-0270-5

M3 - SCORING: Review article

C2 - 31673093

VL - 15

SP - 718

EP - 731

JO - NAT REV NEUROL

JF - NAT REV NEUROL

SN - 1759-4758

IS - 12

ER -