Traumatic and nontraumatic spinal cord injury
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Traumatic and nontraumatic spinal cord injury : pathological insights from neuroimaging. / David, Gergely; Mohammadi, Siawoosh; Martin, Allan R; Cohen-Adad, Julien; Weiskopf, Nikolaus; Thompson, Alan; Freund, Patrick.
in: NAT REV NEUROL, Jahrgang 15, Nr. 12, 12.2019, S. 718-731.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Traumatic and nontraumatic spinal cord injury
T2 - pathological insights from neuroimaging
AU - David, Gergely
AU - Mohammadi, Siawoosh
AU - Martin, Allan R
AU - Cohen-Adad, Julien
AU - Weiskopf, Nikolaus
AU - Thompson, Alan
AU - Freund, Patrick
PY - 2019/12
Y1 - 2019/12
N2 - Pathophysiological changes in the spinal cord white and grey matter resulting from injury can be observed with MRI techniques. These techniques provide sensitive markers of macrostructural and microstructural tissue integrity, which correlate with histological findings. Spinal cord MRI findings in traumatic spinal cord injury (tSCI) and nontraumatic spinal cord injury - the most common form of which is degenerative cervical myelopathy (DCM) - have provided important insights into the pathophysiological processes taking place not just at the focal injury site but also rostral and caudal to the spinal injury. Although tSCI and DCM have different aetiologies, they show similar degrees of spinal cord pathology remote from the injury site, suggesting the involvement of similar secondary degenerative mechanisms. Advanced quantitative MRI protocols that are sensitive to spinal cord pathology have the potential to improve diagnosis and, more importantly, predict outcomes in patients with tSCI or nontraumatic spinal cord injury. This Review describes the insights into tSCI and DCM that have been revealed by neuroimaging and outlines current activities and future directions for the field.
AB - Pathophysiological changes in the spinal cord white and grey matter resulting from injury can be observed with MRI techniques. These techniques provide sensitive markers of macrostructural and microstructural tissue integrity, which correlate with histological findings. Spinal cord MRI findings in traumatic spinal cord injury (tSCI) and nontraumatic spinal cord injury - the most common form of which is degenerative cervical myelopathy (DCM) - have provided important insights into the pathophysiological processes taking place not just at the focal injury site but also rostral and caudal to the spinal injury. Although tSCI and DCM have different aetiologies, they show similar degrees of spinal cord pathology remote from the injury site, suggesting the involvement of similar secondary degenerative mechanisms. Advanced quantitative MRI protocols that are sensitive to spinal cord pathology have the potential to improve diagnosis and, more importantly, predict outcomes in patients with tSCI or nontraumatic spinal cord injury. This Review describes the insights into tSCI and DCM that have been revealed by neuroimaging and outlines current activities and future directions for the field.
KW - Diffusion Tensor Imaging/methods
KW - Humans
KW - Magnetic Resonance Imaging/methods
KW - Neuroimaging/methods
KW - Spinal Cord Injuries/diagnostic imaging
U2 - 10.1038/s41582-019-0270-5
DO - 10.1038/s41582-019-0270-5
M3 - SCORING: Review article
C2 - 31673093
VL - 15
SP - 718
EP - 731
JO - NAT REV NEUROL
JF - NAT REV NEUROL
SN - 1759-4758
IS - 12
ER -