TP53 and Prognosis in mCRPC Survival: Biology or Coincidence?

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Abstract

Cell-free circulating tumor DNA (ctDNA) or circulating tumor cell (CTC) assays are potentially powerful in the treatment of metastatic castration-resistant prostate cancer (mCRPC). A new study suggests that mutation of TP53 supersedes AR in predicting mCRPC survival. A role for TP53 mutation as a driver for mCRPC remains unexplored.See related article by De Laere et al., p. 1766.

Bibliographical data

Original languageEnglish
ISSN1078-0432
DOIs
Publication statusPublished - 15.03.2019
PubMed 30610102