Towards OCT-Navigated Tissue Ablation with a Picosecond Infrared Laser (PIRL) and Mass-Spectrometric Analysis
Standard
Towards OCT-Navigated Tissue Ablation with a Picosecond Infrared Laser (PIRL) and Mass-Spectrometric Analysis. / Schluter, Matthias; Fuh, Manka M; Maier, Stephanie; Otte, Christoph; Kiani, Parnian; Hansen, Nils-Owe; Dwayne Miller, R J; Schluter, Hartmut; Schlaefer, Alexander.
In: Conf Proc IEEE Eng Med Biol Soc, Vol. 2019, 07.2019, p. 158-161.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Towards OCT-Navigated Tissue Ablation with a Picosecond Infrared Laser (PIRL) and Mass-Spectrometric Analysis
AU - Schluter, Matthias
AU - Fuh, Manka M
AU - Maier, Stephanie
AU - Otte, Christoph
AU - Kiani, Parnian
AU - Hansen, Nils-Owe
AU - Dwayne Miller, R J
AU - Schluter, Hartmut
AU - Schlaefer, Alexander
PY - 2019/7
Y1 - 2019/7
N2 - Medical lasers are commonly used in interventions to ablate tumor tissue. Recently, the picosecond infrared laser has been introduced, which greatly decreases damaging of surrounding healthy tissue. Further, its ablation plume contains intact biomolecules which can be collected and analyzed by mass spectrometry. This allows for a specific chracterization of the tissue. For a precise treatment, however, a suitable guidance is needed. Further, spatial information is required if the tissue is to be characterized at different parts in the ablated area. Therefore, we propose a system which employs optical coherence tomography as the guiding imaging modality. We describe a prototypical system which provides automatic ablation of areas defined in the image data. For this purpose, we use a calibration with a robot which drives the laser fiber and collects the arising plume. We demonstrate our system on porcine tissue samples.
AB - Medical lasers are commonly used in interventions to ablate tumor tissue. Recently, the picosecond infrared laser has been introduced, which greatly decreases damaging of surrounding healthy tissue. Further, its ablation plume contains intact biomolecules which can be collected and analyzed by mass spectrometry. This allows for a specific chracterization of the tissue. For a precise treatment, however, a suitable guidance is needed. Further, spatial information is required if the tissue is to be characterized at different parts in the ablated area. Therefore, we propose a system which employs optical coherence tomography as the guiding imaging modality. We describe a prototypical system which provides automatic ablation of areas defined in the image data. For this purpose, we use a calibration with a robot which drives the laser fiber and collects the arising plume. We demonstrate our system on porcine tissue samples.
U2 - 10.1109/EMBC.2019.8856808
DO - 10.1109/EMBC.2019.8856808
M3 - SCORING: Journal article
C2 - 31945868
VL - 2019
SP - 158
EP - 161
ER -