Toll-like receptors as targets in chronic liver diseases.
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Toll-like receptors as targets in chronic liver diseases. / Mencin, A; Kluwe, Johannes; Schwabe, R F.
In: GUT, Vol. 58, No. 5, 5, 2009, p. 704-720.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Toll-like receptors as targets in chronic liver diseases.
AU - Mencin, A
AU - Kluwe, Johannes
AU - Schwabe, R F
PY - 2009
Y1 - 2009
N2 - Toll-like receptors (TLRs) recognise pathogen-associated molecular patterns (PAMPs) to detect the presence of pathogens. In addition to their role in innate immunity, TLRs also play a major role in the regulation of inflammation, even under sterile conditions such as injury and wound healing. This involvement has been suggested to depend, at least in part, on the ability of TLRs to recognise several endogenous TLR ligands termed damage-associated molecular patterns (DAMPs). The liver not only represents a major target of bacterial PAMPs in many disease states but also upregulates several DAMPs following injury. Accordingly, TLR-mediated signals have been implicated in a number of chronic liver diseases. Here, we will summarise recent findings on the role TLRs and TLR ligands in the pathophysiology of liver fibrosis and cirrhosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease and hepatocellular carcinoma, and highlight the potential role of TLR agonists, antagonists and probiotics for the treatment of chronic liver disease.
AB - Toll-like receptors (TLRs) recognise pathogen-associated molecular patterns (PAMPs) to detect the presence of pathogens. In addition to their role in innate immunity, TLRs also play a major role in the regulation of inflammation, even under sterile conditions such as injury and wound healing. This involvement has been suggested to depend, at least in part, on the ability of TLRs to recognise several endogenous TLR ligands termed damage-associated molecular patterns (DAMPs). The liver not only represents a major target of bacterial PAMPs in many disease states but also upregulates several DAMPs following injury. Accordingly, TLR-mediated signals have been implicated in a number of chronic liver diseases. Here, we will summarise recent findings on the role TLRs and TLR ligands in the pathophysiology of liver fibrosis and cirrhosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease and hepatocellular carcinoma, and highlight the potential role of TLR agonists, antagonists and probiotics for the treatment of chronic liver disease.
KW - Humans
KW - Bacterial Translocation
KW - Chronic Disease
KW - Hyaluronic Acid immunology
KW - Immunity, Innate physiology
KW - Ligands
KW - Liver metabolism
KW - Liver Diseases etiology
KW - Probiotics therapeutic use
KW - Signal Transduction immunology
KW - Toll-Like Receptors agonists
KW - Up-Regulation
KW - Humans
KW - Bacterial Translocation
KW - Chronic Disease
KW - Hyaluronic Acid immunology
KW - Immunity, Innate physiology
KW - Ligands
KW - Liver metabolism
KW - Liver Diseases etiology
KW - Probiotics therapeutic use
KW - Signal Transduction immunology
KW - Toll-Like Receptors agonists
KW - Up-Regulation
M3 - SCORING: Zeitschriftenaufsatz
VL - 58
SP - 704
EP - 720
JO - GUT
JF - GUT
SN - 0017-5749
IS - 5
M1 - 5
ER -