TNF in the liver:targeting a central player in inflammation
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TNF in the liver:targeting a central player in inflammation. / Tiegs, Gisa; Horst, Andrea K.
In: SEMIN IMMUNOPATHOL, Vol. 44, No. 4, 07.2022, p. 445-459.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - TNF in the liver:targeting a central player in inflammation
AU - Tiegs, Gisa
AU - Horst, Andrea K
N1 - © 2022. The Author(s).
PY - 2022/7
Y1 - 2022/7
N2 - Tumour necrosis factor-α (TNF) is a multifunctional cytokine. First recognized as an endogenous soluble factor that induces necrosis of solid tumours, TNF became increasingly important as pro-inflammatory cytokine being involved in the immunopathogenesis of several autoimmune diseases. In the liver, TNF induces numerous biological responses such as hepatocyte apoptosis and necroptosis, liver inflammation and regeneration, and autoimmunity, but also progression to hepatocellular carcinoma. Considering these multiple functions of TNF in the liver, we propose anti-TNF therapies that specifically target TNF signalling at the level of its specific receptors.
AB - Tumour necrosis factor-α (TNF) is a multifunctional cytokine. First recognized as an endogenous soluble factor that induces necrosis of solid tumours, TNF became increasingly important as pro-inflammatory cytokine being involved in the immunopathogenesis of several autoimmune diseases. In the liver, TNF induces numerous biological responses such as hepatocyte apoptosis and necroptosis, liver inflammation and regeneration, and autoimmunity, but also progression to hepatocellular carcinoma. Considering these multiple functions of TNF in the liver, we propose anti-TNF therapies that specifically target TNF signalling at the level of its specific receptors.
U2 - 10.1007/s00281-022-00910-2
DO - 10.1007/s00281-022-00910-2
M3 - SCORING: Review article
C2 - 35122118
VL - 44
SP - 445
EP - 459
JO - SEMIN IMMUNOPATHOL
JF - SEMIN IMMUNOPATHOL
SN - 1863-2297
IS - 4
ER -