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TNF in the liver:targeting a central player in inflammation

Standard

TNF in the liver:targeting a central player in inflammation. / Tiegs, Gisa; Horst, Andrea K.

in: SEMIN IMMUNOPATHOL, Jahrgang 44, Nr. 4, 07.2022, S. 445-459.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Tiegs, G & Horst, AK 2022, 'TNF in the liver:targeting a central player in inflammation', SEMIN IMMUNOPATHOL, Jg. 44, Nr. 4, S. 445-459. https://doi.org/10.1007/s00281-022-00910-2

APA

Tiegs, G., & Horst, A. K. (2022). TNF in the liver:targeting a central player in inflammation. SEMIN IMMUNOPATHOL, 44(4), 445-459. https://doi.org/10.1007/s00281-022-00910-2

Vancouver

Tiegs G, Horst AK. TNF in the liver:targeting a central player in inflammation. SEMIN IMMUNOPATHOL. 2022 Jul;44(4):445-459. https://doi.org/10.1007/s00281-022-00910-2

Bibtex

@article{df46ee77deb54c8ea209bf431732dc29,
title = "TNF in the liver:targeting a central player in inflammation",
abstract = "Tumour necrosis factor-α (TNF) is a multifunctional cytokine. First recognized as an endogenous soluble factor that induces necrosis of solid tumours, TNF became increasingly important as pro-inflammatory cytokine being involved in the immunopathogenesis of several autoimmune diseases. In the liver, TNF induces numerous biological responses such as hepatocyte apoptosis and necroptosis, liver inflammation and regeneration, and autoimmunity, but also progression to hepatocellular carcinoma. Considering these multiple functions of TNF in the liver, we propose anti-TNF therapies that specifically target TNF signalling at the level of its specific receptors.",
author = "Gisa Tiegs and Horst, {Andrea K}",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = jul,
doi = "10.1007/s00281-022-00910-2",
language = "English",
volume = "44",
pages = "445--459",
journal = "SEMIN IMMUNOPATHOL",
issn = "1863-2297",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - TNF in the liver:targeting a central player in inflammation

AU - Tiegs, Gisa

AU - Horst, Andrea K

N1 - © 2022. The Author(s).

PY - 2022/7

Y1 - 2022/7

N2 - Tumour necrosis factor-α (TNF) is a multifunctional cytokine. First recognized as an endogenous soluble factor that induces necrosis of solid tumours, TNF became increasingly important as pro-inflammatory cytokine being involved in the immunopathogenesis of several autoimmune diseases. In the liver, TNF induces numerous biological responses such as hepatocyte apoptosis and necroptosis, liver inflammation and regeneration, and autoimmunity, but also progression to hepatocellular carcinoma. Considering these multiple functions of TNF in the liver, we propose anti-TNF therapies that specifically target TNF signalling at the level of its specific receptors.

AB - Tumour necrosis factor-α (TNF) is a multifunctional cytokine. First recognized as an endogenous soluble factor that induces necrosis of solid tumours, TNF became increasingly important as pro-inflammatory cytokine being involved in the immunopathogenesis of several autoimmune diseases. In the liver, TNF induces numerous biological responses such as hepatocyte apoptosis and necroptosis, liver inflammation and regeneration, and autoimmunity, but also progression to hepatocellular carcinoma. Considering these multiple functions of TNF in the liver, we propose anti-TNF therapies that specifically target TNF signalling at the level of its specific receptors.

U2 - 10.1007/s00281-022-00910-2

DO - 10.1007/s00281-022-00910-2

M3 - SCORING: Review article

C2 - 35122118

VL - 44

SP - 445

EP - 459

JO - SEMIN IMMUNOPATHOL

JF - SEMIN IMMUNOPATHOL

SN - 1863-2297

IS - 4

ER -