TNF and bone
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TNF and bone. / David, Jean-Pierre; Schett, Georg.
In: Current directions in autoimmunity, Vol. 11, 01.01.2010, p. 135-44.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research
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TY - JOUR
T1 - TNF and bone
AU - David, Jean-Pierre
AU - Schett, Georg
N1 - Copyright (c) 2010 S. Karger AG, Basel.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Bone is subject to permanent remodeling during development and through life. This activity is essential for (a) proper shaping and growth of each bone during development; (b) maintenance of bone mass as well as structural integrity of the micro architecture of bone through adult life, and (c) tissue repair needed for healing of fracture as well as of micro-damage. In addition to genetically linked rare developmental diseases, disturbances in bone remodeling are causing common bone pathologies, which severely impair the quality of life of patients. Among them are postmenopausal osteoporosis and local as well as systemic bone loss observed in chronic inflammatory diseases such as rheumatoid arthritis. The role of TNF-alpha in mediating bone remodeling will be presented and discussed in this chapter.
AB - Bone is subject to permanent remodeling during development and through life. This activity is essential for (a) proper shaping and growth of each bone during development; (b) maintenance of bone mass as well as structural integrity of the micro architecture of bone through adult life, and (c) tissue repair needed for healing of fracture as well as of micro-damage. In addition to genetically linked rare developmental diseases, disturbances in bone remodeling are causing common bone pathologies, which severely impair the quality of life of patients. Among them are postmenopausal osteoporosis and local as well as systemic bone loss observed in chronic inflammatory diseases such as rheumatoid arthritis. The role of TNF-alpha in mediating bone remodeling will be presented and discussed in this chapter.
KW - Animals
KW - Bone Remodeling
KW - Bone and Bones
KW - Cell Differentiation
KW - Humans
KW - Mice
KW - Models, Biological
KW - Osteoblasts
KW - Osteoclasts
KW - Receptors, Tumor Necrosis Factor
KW - Tumor Necrosis Factor-alpha
U2 - 10.1159/000289202
DO - 10.1159/000289202
M3 - SCORING: Journal article
C2 - 20173392
VL - 11
SP - 135
EP - 144
ER -