TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signaling.

  • Jan C Brase
  • Marc Johannes
  • Heiko Mannsperger
  • Maria Fälth
  • Jennifer Metzger
  • Lukasz A Kacprzyk
  • Tatjana Andrasiuk
  • Stephan Gade
  • Michael Meister
  • Hüseyin Sirma
  • Guido Sauter
  • Ronald Simon
  • Thorsten Schlomm
  • Tim Beissbarth
  • Ulrike Korf
  • Ruprecht Kuner
  • Holger Sültmann

Abstract

TMPRSS2-ERG gene fusions occur in about 50% of all prostate cancer cases and represent promising markers for molecular subtyping. Although TMPRSS2-ERG fusion seems to be a critical event in prostate cancer, the precise functional role in cancer development and progression is still unclear.

Bibliographical data

Original languageEnglish
ISSN1471-2407
DOIs
Publication statusPublished - 2011
pubmed 22142399