Tissue-resident immunity in the lung
Standard
Tissue-resident immunity in the lung : a first-line defense at the environmental interface. / Zazara, Dimitra E; Belios, Ioannis; Lücke, Jöran; Zhang, Tao; Giannou, Anastasios D.
In: SEMIN IMMUNOPATHOL, Vol. 44, No. 6, 11.2022, p. 827-854.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Tissue-resident immunity in the lung
T2 - a first-line defense at the environmental interface
AU - Zazara, Dimitra E
AU - Belios, Ioannis
AU - Lücke, Jöran
AU - Zhang, Tao
AU - Giannou, Anastasios D
N1 - © 2022. The Author(s).
PY - 2022/11
Y1 - 2022/11
N2 - The lung is a vital organ that incessantly faces external environmental challenges. Its homeostasis and unimpeded vital function are ensured by the respiratory epithelium working hand in hand with an intricate fine-tuned tissue-resident immune cell network. Lung tissue-resident immune cells span across the innate and adaptive immunity and protect from infectious agents but can also prove to be pathogenic if dysregulated. Here, we review the innate and adaptive immune cell subtypes comprising lung-resident immunity and discuss their ontogeny and role in distinct respiratory diseases. An improved understanding of the role of lung-resident immunity and how its function is dysregulated under pathological conditions can shed light on the pathogenesis of respiratory diseases.
AB - The lung is a vital organ that incessantly faces external environmental challenges. Its homeostasis and unimpeded vital function are ensured by the respiratory epithelium working hand in hand with an intricate fine-tuned tissue-resident immune cell network. Lung tissue-resident immune cells span across the innate and adaptive immunity and protect from infectious agents but can also prove to be pathogenic if dysregulated. Here, we review the innate and adaptive immune cell subtypes comprising lung-resident immunity and discuss their ontogeny and role in distinct respiratory diseases. An improved understanding of the role of lung-resident immunity and how its function is dysregulated under pathological conditions can shed light on the pathogenesis of respiratory diseases.
KW - Humans
KW - Immunity, Innate
KW - Lung
KW - Adaptive Immunity
KW - Homeostasis
U2 - 10.1007/s00281-022-00964-2
DO - 10.1007/s00281-022-00964-2
M3 - SCORING: Review article
C2 - 36305904
VL - 44
SP - 827
EP - 854
JO - SEMIN IMMUNOPATHOL
JF - SEMIN IMMUNOPATHOL
SN - 1863-2297
IS - 6
ER -