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Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine

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Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine. / Sagebiel, Adrian F; Steinert, Fenja; Lunemann, Sebastian; Körner, Christian; Schreurs, Renée R C E; Altfeld, Marcus; Perez, Daniel; Reinshagen, Konrad; Bunders, Madeleine J.

In: NAT COMMUN, Vol. 10, No. 1, 28.02.2019, p. 975.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sagebiel, AF, Steinert, F, Lunemann, S, Körner, C, Schreurs, RRCE, Altfeld, M, Perez, D, Reinshagen, K & Bunders, MJ 2019, 'Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine', NAT COMMUN, vol. 10, no. 1, pp. 975. https://doi.org/10.1038/s41467-018-08267-7

APA

Sagebiel, A. F., Steinert, F., Lunemann, S., Körner, C., Schreurs, R. R. C. E., Altfeld, M., Perez, D., Reinshagen, K., & Bunders, M. J. (2019). Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine. NAT COMMUN, 10(1), 975. https://doi.org/10.1038/s41467-018-08267-7

Vancouver

Sagebiel AF, Steinert F, Lunemann S, Körner C, Schreurs RRCE, Altfeld M et al. Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine. NAT COMMUN. 2019 Feb 28;10(1):975. https://doi.org/10.1038/s41467-018-08267-7

Bibtex

@article{97d345b808854ec1b9deba35bd7f1f33,
title = "Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine",
abstract = "Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear. Here we show that CD103+ NK cells are the major ILC population in the small intestines of infants. When compared to adult intestinal NK cells, infant intestinal NK cells exhibit a robust effector phenotype, characterized by Eomes, perforin and granzyme B expression, and superior degranulation capacity. Absolute intestinal NK cell numbers decrease gradually during the first year of life, coinciding with an influx of intestinal Eomes+ T cells; by contrast, epithelial NKp44+CD69+ NK cells with less cytotoxic capacity persist in adults. In conclusion, NK cells are abundant in infant intestines, where they can provide effector functions while Eomes+ T cell responses mature.",
keywords = "Adult, Aged, Antigens, CD/metabolism, Granzymes/metabolism, Humans, Immunity, Innate, Immunophenotyping, Infant, Integrin alpha Chains/metabolism, Intestines/cytology, Killer Cells, Natural/classification, Middle Aged, NK Cell Lectin-Like Receptor Subfamily C/metabolism, Perforin/metabolism, T-Box Domain Proteins/metabolism, Tissue Distribution",
author = "Sagebiel, {Adrian F} and Fenja Steinert and Sebastian Lunemann and Christian K{\"o}rner and Schreurs, {Ren{\'e}e R C E} and Marcus Altfeld and Daniel Perez and Konrad Reinshagen and Bunders, {Madeleine J}",
year = "2019",
month = feb,
day = "28",
doi = "10.1038/s41467-018-08267-7",
language = "English",
volume = "10",
pages = "975",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine

AU - Sagebiel, Adrian F

AU - Steinert, Fenja

AU - Lunemann, Sebastian

AU - Körner, Christian

AU - Schreurs, Renée R C E

AU - Altfeld, Marcus

AU - Perez, Daniel

AU - Reinshagen, Konrad

AU - Bunders, Madeleine J

PY - 2019/2/28

Y1 - 2019/2/28

N2 - Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear. Here we show that CD103+ NK cells are the major ILC population in the small intestines of infants. When compared to adult intestinal NK cells, infant intestinal NK cells exhibit a robust effector phenotype, characterized by Eomes, perforin and granzyme B expression, and superior degranulation capacity. Absolute intestinal NK cell numbers decrease gradually during the first year of life, coinciding with an influx of intestinal Eomes+ T cells; by contrast, epithelial NKp44+CD69+ NK cells with less cytotoxic capacity persist in adults. In conclusion, NK cells are abundant in infant intestines, where they can provide effector functions while Eomes+ T cell responses mature.

AB - Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear. Here we show that CD103+ NK cells are the major ILC population in the small intestines of infants. When compared to adult intestinal NK cells, infant intestinal NK cells exhibit a robust effector phenotype, characterized by Eomes, perforin and granzyme B expression, and superior degranulation capacity. Absolute intestinal NK cell numbers decrease gradually during the first year of life, coinciding with an influx of intestinal Eomes+ T cells; by contrast, epithelial NKp44+CD69+ NK cells with less cytotoxic capacity persist in adults. In conclusion, NK cells are abundant in infant intestines, where they can provide effector functions while Eomes+ T cell responses mature.

KW - Adult

KW - Aged

KW - Antigens, CD/metabolism

KW - Granzymes/metabolism

KW - Humans

KW - Immunity, Innate

KW - Immunophenotyping

KW - Infant

KW - Integrin alpha Chains/metabolism

KW - Intestines/cytology

KW - Killer Cells, Natural/classification

KW - Middle Aged

KW - NK Cell Lectin-Like Receptor Subfamily C/metabolism

KW - Perforin/metabolism

KW - T-Box Domain Proteins/metabolism

KW - Tissue Distribution

U2 - 10.1038/s41467-018-08267-7

DO - 10.1038/s41467-018-08267-7

M3 - SCORING: Journal article

C2 - 30816112

VL - 10

SP - 975

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -