Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine
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Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine. / Sagebiel, Adrian F; Steinert, Fenja; Lunemann, Sebastian; Körner, Christian; Schreurs, Renée R C E; Altfeld, Marcus; Perez, Daniel; Reinshagen, Konrad; Bunders, Madeleine J.
in: NAT COMMUN, Jahrgang 10, Nr. 1, 28.02.2019, S. 975.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Tissue-resident Eomes+ NK cells are the major innate lymphoid cell population in human infant intestine
AU - Sagebiel, Adrian F
AU - Steinert, Fenja
AU - Lunemann, Sebastian
AU - Körner, Christian
AU - Schreurs, Renée R C E
AU - Altfeld, Marcus
AU - Perez, Daniel
AU - Reinshagen, Konrad
AU - Bunders, Madeleine J
PY - 2019/2/28
Y1 - 2019/2/28
N2 - Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear. Here we show that CD103+ NK cells are the major ILC population in the small intestines of infants. When compared to adult intestinal NK cells, infant intestinal NK cells exhibit a robust effector phenotype, characterized by Eomes, perforin and granzyme B expression, and superior degranulation capacity. Absolute intestinal NK cell numbers decrease gradually during the first year of life, coinciding with an influx of intestinal Eomes+ T cells; by contrast, epithelial NKp44+CD69+ NK cells with less cytotoxic capacity persist in adults. In conclusion, NK cells are abundant in infant intestines, where they can provide effector functions while Eomes+ T cell responses mature.
AB - Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear. Here we show that CD103+ NK cells are the major ILC population in the small intestines of infants. When compared to adult intestinal NK cells, infant intestinal NK cells exhibit a robust effector phenotype, characterized by Eomes, perforin and granzyme B expression, and superior degranulation capacity. Absolute intestinal NK cell numbers decrease gradually during the first year of life, coinciding with an influx of intestinal Eomes+ T cells; by contrast, epithelial NKp44+CD69+ NK cells with less cytotoxic capacity persist in adults. In conclusion, NK cells are abundant in infant intestines, where they can provide effector functions while Eomes+ T cell responses mature.
KW - Adult
KW - Aged
KW - Antigens, CD/metabolism
KW - Granzymes/metabolism
KW - Humans
KW - Immunity, Innate
KW - Immunophenotyping
KW - Infant
KW - Integrin alpha Chains/metabolism
KW - Intestines/cytology
KW - Killer Cells, Natural/classification
KW - Middle Aged
KW - NK Cell Lectin-Like Receptor Subfamily C/metabolism
KW - Perforin/metabolism
KW - T-Box Domain Proteins/metabolism
KW - Tissue Distribution
U2 - 10.1038/s41467-018-08267-7
DO - 10.1038/s41467-018-08267-7
M3 - SCORING: Journal article
C2 - 30816112
VL - 10
SP - 975
JO - NAT COMMUN
JF - NAT COMMUN
SN - 2041-1723
IS - 1
ER -