Research ExplorerPublicationsTime-resolved perfusion imaging at the angiography suite

Time-resolved perfusion imaging at the angiography suite

Standard

Time-resolved perfusion imaging at the angiography suite : preclinical comparison of a new flat-detector application to computed tomography perfusion. / Jürgens, Julian H W; Schulz, Nadine; Wybranski, Christian; Seidensticker, Max; Streit, Sebastian; Brauner, Jan; Wohlgemuth, Walter A; Deuerling-Zheng, Yu; Ricke, Jens; Dudeck, Oliver.

In: INVEST RADIOL, Vol. 50, No. 2, 02.2015, p. 108-13.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jürgens, JHW, Schulz, N, Wybranski, C, Seidensticker, M, Streit, S, Brauner, J, Wohlgemuth, WA, Deuerling-Zheng, Y, Ricke, J & Dudeck, O 2015, 'Time-resolved perfusion imaging at the angiography suite: preclinical comparison of a new flat-detector application to computed tomography perfusion', INVEST RADIOL, vol. 50, no. 2, pp. 108-13. https://doi.org/10.1097/RLI.0000000000000107

APA

Jürgens, J. H. W., Schulz, N., Wybranski, C., Seidensticker, M., Streit, S., Brauner, J., Wohlgemuth, W. A., Deuerling-Zheng, Y., Ricke, J., & Dudeck, O. (2015). Time-resolved perfusion imaging at the angiography suite: preclinical comparison of a new flat-detector application to computed tomography perfusion. INVEST RADIOL, 50(2), 108-13. https://doi.org/10.1097/RLI.0000000000000107

Vancouver

Jürgens JHW, Schulz N, Wybranski C, Seidensticker M, Streit S, Brauner J et al. Time-resolved perfusion imaging at the angiography suite: preclinical comparison of a new flat-detector application to computed tomography perfusion. INVEST RADIOL. 2015 Feb;50(2):108-13. https://doi.org/10.1097/RLI.0000000000000107

Bibtex

@article{0b50c9e5f7214da1a4b166eb81ce7284,
title = "Time-resolved perfusion imaging at the angiography suite: preclinical comparison of a new flat-detector application to computed tomography perfusion",
abstract = "OBJECTIVES: The objective of this study was to compare the parameter maps of a new flat-panel detector application for time-resolved perfusion imaging in the angiography room (FD-CTP) with computed tomography perfusion (CTP) in an experimental tumor model.MATERIALS AND METHODS: Twenty-four VX2 tumors were implanted into the hind legs of 12 rabbits. Three weeks later, FD-CTP (Artis zeego; Siemens) and CTP (SOMATOM Definition AS +; Siemens) were performed. The parameter maps for the FD-CTP were calculated using a prototype software, and those for the CTP were calculated with VPCT-body software on a dedicated syngo MultiModality Workplace. The parameters were compared using Pearson product-moment correlation coefficient and linear regression analysis.RESULTS: The Pearson product-moment correlation coefficient showed good correlation values for both the intratumoral blood volume of 0.848 (P < 0.01) and the blood flow of 0.698 (P < 0.01). The linear regression analysis of the perfusion between FD-CTP and CTP showed for the blood volume a regression equation y = 4.44x + 36.72 (P < 0.01) and for the blood flow y = 0.75x + 14.61 (P < 0.01).CONCLUSIONS: This preclinical study provides evidence that FD-CTP allows a time-resolved (dynamic) perfusion imaging of tumors similar to CTP, which provides the basis for clinical applications such as the assessment of tumor response to locoregional therapies directly in the angiography suite.",
keywords = "Algorithms, Angiography, Animals, Cell Line, Tumor, Neoplasms, Experimental, Rabbits, Radiographic Image Enhancement, Radiographic Image Interpretation, Computer-Assisted, Reproducibility of Results, Sensitivity and Specificity, Software, Tomography, X-Ray Computed, X-Ray Intensifying Screens, Journal Article",
author = "J{\"u}rgens, {Julian H W} and Nadine Schulz and Christian Wybranski and Max Seidensticker and Sebastian Streit and Jan Brauner and Wohlgemuth, {Walter A} and Yu Deuerling-Zheng and Jens Ricke and Oliver Dudeck",
year = "2015",
month = feb,
doi = "10.1097/RLI.0000000000000107",
language = "English",
volume = "50",
pages = "108--13",
journal = "INVEST RADIOL",
issn = "0020-9996",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Time-resolved perfusion imaging at the angiography suite

T2 - preclinical comparison of a new flat-detector application to computed tomography perfusion

AU - Jürgens, Julian H W

AU - Schulz, Nadine

AU - Wybranski, Christian

AU - Seidensticker, Max

AU - Streit, Sebastian

AU - Brauner, Jan

AU - Wohlgemuth, Walter A

AU - Deuerling-Zheng, Yu

AU - Ricke, Jens

AU - Dudeck, Oliver

PY - 2015/2

Y1 - 2015/2

N2 - OBJECTIVES: The objective of this study was to compare the parameter maps of a new flat-panel detector application for time-resolved perfusion imaging in the angiography room (FD-CTP) with computed tomography perfusion (CTP) in an experimental tumor model.MATERIALS AND METHODS: Twenty-four VX2 tumors were implanted into the hind legs of 12 rabbits. Three weeks later, FD-CTP (Artis zeego; Siemens) and CTP (SOMATOM Definition AS +; Siemens) were performed. The parameter maps for the FD-CTP were calculated using a prototype software, and those for the CTP were calculated with VPCT-body software on a dedicated syngo MultiModality Workplace. The parameters were compared using Pearson product-moment correlation coefficient and linear regression analysis.RESULTS: The Pearson product-moment correlation coefficient showed good correlation values for both the intratumoral blood volume of 0.848 (P < 0.01) and the blood flow of 0.698 (P < 0.01). The linear regression analysis of the perfusion between FD-CTP and CTP showed for the blood volume a regression equation y = 4.44x + 36.72 (P < 0.01) and for the blood flow y = 0.75x + 14.61 (P < 0.01).CONCLUSIONS: This preclinical study provides evidence that FD-CTP allows a time-resolved (dynamic) perfusion imaging of tumors similar to CTP, which provides the basis for clinical applications such as the assessment of tumor response to locoregional therapies directly in the angiography suite.

AB - OBJECTIVES: The objective of this study was to compare the parameter maps of a new flat-panel detector application for time-resolved perfusion imaging in the angiography room (FD-CTP) with computed tomography perfusion (CTP) in an experimental tumor model.MATERIALS AND METHODS: Twenty-four VX2 tumors were implanted into the hind legs of 12 rabbits. Three weeks later, FD-CTP (Artis zeego; Siemens) and CTP (SOMATOM Definition AS +; Siemens) were performed. The parameter maps for the FD-CTP were calculated using a prototype software, and those for the CTP were calculated with VPCT-body software on a dedicated syngo MultiModality Workplace. The parameters were compared using Pearson product-moment correlation coefficient and linear regression analysis.RESULTS: The Pearson product-moment correlation coefficient showed good correlation values for both the intratumoral blood volume of 0.848 (P < 0.01) and the blood flow of 0.698 (P < 0.01). The linear regression analysis of the perfusion between FD-CTP and CTP showed for the blood volume a regression equation y = 4.44x + 36.72 (P < 0.01) and for the blood flow y = 0.75x + 14.61 (P < 0.01).CONCLUSIONS: This preclinical study provides evidence that FD-CTP allows a time-resolved (dynamic) perfusion imaging of tumors similar to CTP, which provides the basis for clinical applications such as the assessment of tumor response to locoregional therapies directly in the angiography suite.

KW - Algorithms

KW - Angiography

KW - Animals

KW - Cell Line, Tumor

KW - Neoplasms, Experimental

KW - Rabbits

KW - Radiographic Image Enhancement

KW - Radiographic Image Interpretation, Computer-Assisted

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Software

KW - Tomography, X-Ray Computed

KW - X-Ray Intensifying Screens

KW - Journal Article

U2 - 10.1097/RLI.0000000000000107

DO - 10.1097/RLI.0000000000000107

M3 - SCORING: Journal article

C2 - 25493415

VL - 50

SP - 108

EP - 113

JO - INVEST RADIOL

JF - INVEST RADIOL

SN - 0020-9996

IS - 2

ER -