Time-resolved perfusion imaging at the angiography suite
Standard
Time-resolved perfusion imaging at the angiography suite : preclinical comparison of a new flat-detector application to computed tomography perfusion. / Jürgens, Julian H W; Schulz, Nadine; Wybranski, Christian; Seidensticker, Max; Streit, Sebastian; Brauner, Jan; Wohlgemuth, Walter A; Deuerling-Zheng, Yu; Ricke, Jens; Dudeck, Oliver.
in: INVEST RADIOL, Jahrgang 50, Nr. 2, 02.2015, S. 108-13.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Time-resolved perfusion imaging at the angiography suite
T2 - preclinical comparison of a new flat-detector application to computed tomography perfusion
AU - Jürgens, Julian H W
AU - Schulz, Nadine
AU - Wybranski, Christian
AU - Seidensticker, Max
AU - Streit, Sebastian
AU - Brauner, Jan
AU - Wohlgemuth, Walter A
AU - Deuerling-Zheng, Yu
AU - Ricke, Jens
AU - Dudeck, Oliver
PY - 2015/2
Y1 - 2015/2
N2 - OBJECTIVES: The objective of this study was to compare the parameter maps of a new flat-panel detector application for time-resolved perfusion imaging in the angiography room (FD-CTP) with computed tomography perfusion (CTP) in an experimental tumor model.MATERIALS AND METHODS: Twenty-four VX2 tumors were implanted into the hind legs of 12 rabbits. Three weeks later, FD-CTP (Artis zeego; Siemens) and CTP (SOMATOM Definition AS +; Siemens) were performed. The parameter maps for the FD-CTP were calculated using a prototype software, and those for the CTP were calculated with VPCT-body software on a dedicated syngo MultiModality Workplace. The parameters were compared using Pearson product-moment correlation coefficient and linear regression analysis.RESULTS: The Pearson product-moment correlation coefficient showed good correlation values for both the intratumoral blood volume of 0.848 (P < 0.01) and the blood flow of 0.698 (P < 0.01). The linear regression analysis of the perfusion between FD-CTP and CTP showed for the blood volume a regression equation y = 4.44x + 36.72 (P < 0.01) and for the blood flow y = 0.75x + 14.61 (P < 0.01).CONCLUSIONS: This preclinical study provides evidence that FD-CTP allows a time-resolved (dynamic) perfusion imaging of tumors similar to CTP, which provides the basis for clinical applications such as the assessment of tumor response to locoregional therapies directly in the angiography suite.
AB - OBJECTIVES: The objective of this study was to compare the parameter maps of a new flat-panel detector application for time-resolved perfusion imaging in the angiography room (FD-CTP) with computed tomography perfusion (CTP) in an experimental tumor model.MATERIALS AND METHODS: Twenty-four VX2 tumors were implanted into the hind legs of 12 rabbits. Three weeks later, FD-CTP (Artis zeego; Siemens) and CTP (SOMATOM Definition AS +; Siemens) were performed. The parameter maps for the FD-CTP were calculated using a prototype software, and those for the CTP were calculated with VPCT-body software on a dedicated syngo MultiModality Workplace. The parameters were compared using Pearson product-moment correlation coefficient and linear regression analysis.RESULTS: The Pearson product-moment correlation coefficient showed good correlation values for both the intratumoral blood volume of 0.848 (P < 0.01) and the blood flow of 0.698 (P < 0.01). The linear regression analysis of the perfusion between FD-CTP and CTP showed for the blood volume a regression equation y = 4.44x + 36.72 (P < 0.01) and for the blood flow y = 0.75x + 14.61 (P < 0.01).CONCLUSIONS: This preclinical study provides evidence that FD-CTP allows a time-resolved (dynamic) perfusion imaging of tumors similar to CTP, which provides the basis for clinical applications such as the assessment of tumor response to locoregional therapies directly in the angiography suite.
KW - Algorithms
KW - Angiography
KW - Animals
KW - Cell Line, Tumor
KW - Neoplasms, Experimental
KW - Rabbits
KW - Radiographic Image Enhancement
KW - Radiographic Image Interpretation, Computer-Assisted
KW - Reproducibility of Results
KW - Sensitivity and Specificity
KW - Software
KW - Tomography, X-Ray Computed
KW - X-Ray Intensifying Screens
KW - Journal Article
U2 - 10.1097/RLI.0000000000000107
DO - 10.1097/RLI.0000000000000107
M3 - SCORING: Journal article
C2 - 25493415
VL - 50
SP - 108
EP - 113
JO - INVEST RADIOL
JF - INVEST RADIOL
SN - 0020-9996
IS - 2
ER -