Tight junctions: is there a role in dermatology?
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Tight junctions: is there a role in dermatology? / Kirschner, Nina; Bohner, Claudia; Rachow, Susanne; Brandner, Johanna.
In: ARCH DERMATOL RES, Vol. 302, No. 7, 7, 2010, p. 483-493.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Tight junctions: is there a role in dermatology?
AU - Kirschner, Nina
AU - Bohner, Claudia
AU - Rachow, Susanne
AU - Brandner, Johanna
PY - 2010
Y1 - 2010
N2 - A variety of tight junction (TJ) proteins including claudins, occludin, tricellulin, zonula occludens-proteins and junctional adhesion molecules have been identified in complex localization patterns in mammalian epidermis. Their expression and/or localization is frequently altered in skin diseases including skin tumors. However, our understanding of the function(s) of TJ and TJ proteins in the skin is, even though rapidly increasing, still limited. This review summarizes our current knowledge of the involvement of TJ and TJ proteins in mammalian skin in functions ascribed to TJ in simple epithelia, such as barrier function, polarity, gene expression, proliferation, differentiation, and vesicle transport.
AB - A variety of tight junction (TJ) proteins including claudins, occludin, tricellulin, zonula occludens-proteins and junctional adhesion molecules have been identified in complex localization patterns in mammalian epidermis. Their expression and/or localization is frequently altered in skin diseases including skin tumors. However, our understanding of the function(s) of TJ and TJ proteins in the skin is, even though rapidly increasing, still limited. This review summarizes our current knowledge of the involvement of TJ and TJ proteins in mammalian skin in functions ascribed to TJ in simple epithelia, such as barrier function, polarity, gene expression, proliferation, differentiation, and vesicle transport.
M3 - SCORING: Zeitschriftenaufsatz
VL - 302
SP - 483
EP - 493
JO - ARCH DERMATOL RES
JF - ARCH DERMATOL RES
SN - 0340-3696
IS - 7
M1 - 7
ER -